Summary
Evidence from intracellular recording and voltage-clamping in hippocampal slices indicates that brief anoxia (2–4 min) strongly depresses excitability and synaptic potentials by raising K conductance and inactivating Ca-currents. Both effects could be caused by a rise in intracellular free Ca2+, but other explanations are not excluded.
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References
Andersen P (1960) Interhippocampal impulses. Acta Physiol Scand 48: 178–208
Atwater I, Dawson CM, Ribalet B and Rojas E (1979) Potassium permeability activated by intracellular calcium ion concentration in the pancreatic 0-cell. J Physiol 288: 575–588
Balestrino M, Aitken PG and Somjen GG (1986) The effects of moderate changes of extracellular K+ and Ca2+ on synaptic and neural function in the CA1 region of the hippocampal slice. Brain Res 377: 229–239
Brooks CMcC and Eccles JC (1947) A study of the effects of anaesthesia and asphyxia on the monosynaptic pathway through the spinal cord. J Neurophysiol 10: 349–360
Brown DA and Griffith WH (1983) Persistent slow inward calcium current in voltage-clamped hippocampal neurones of the guinea-pig. J Physiol 337: 303–320
Castle NA and Haylett DG (1987) Effect of channel blockers on potassium efflux from metabolically exhausted frog skeletal muscle. J Physiol 383: 31–43
Cook DL and Hales CN (1984) Intracellular ATP directly blocks K+ channels in pancreatic /J-cells. Nature 311: 271–273.
Eckert R and Chad JE (1984) Inactivation of Ca channels. Prog Biophys Mol Biol M: 215–267
Fujiwara N, Higashi H, Shimoki K and Yoshimura M (1987) Effects of hypoxia on rat hippocampal neurones in vitro. J Physiol 384: 131–151
Glötzner F (1967) Intracelluläre Potentiale, EEG und corticale
Gleichspannung an der sensomotorisehen Rinde der Katze bei akuter Hypoxie. Archiv Psychiat Nervenkr 210: 274–296
Grossman RG and Williams VF (1971) Electrical activity and ultrastructure of cortical neurons and synapses in ischemia. In: Brierly JB and Meldrum BS (eds). Brain Hypoxia. JB Lippincott Co Philadelphia: 61–75
Hansen AJ (1985) Effect of anoxia on ion distribution in the brain. Physiol Rev 65: 101–148.
Hansen AJ, Hounsgaard J and Jahnsen H (1982) Anoxia increases potassium conductance in hippocampal nerve cells. Acta Physiol Scand 115: 301–310
Jahnsen H (1986) Responses to neurons in isolated preparations of the mammalian central nervous system. Prog Neurobiol 27: 351–372
Johnston D, Hablitz JJ and Wilson WA (1980) Voltage clamp discloses slow inward current in hippocampal burst-firing neurones. Nature 286: 391–393
Kakei M, Noma A and Shibasaki T (1985) Properties of adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells. J Physiol 363: 441–462
Krnjevic K (1975) Coupling of neuronal metabolism and electrical activity. In: Ingvar DH and Lassen NA (eds). Brain Work: The coupling of function, metabolism and blood flow in the brain. Alfred Benzon Symposium VIII/Copenhagen Munsgaard: 65–78
Krnjevic K, Cherubini E and Ben-Ari Y (1987) Effects of anoxia on synaptic transmission and calcium currents in immature hippocampus. Soc Neurosci Abstr 13: 1355
Krnjevic K and Leblond J (1987) Mechanism of hyperpolarizing response of hippocampal cells in isolated slices to anoxia. J Physiol 382: 79 P
Krnjevic K and Leblond J (1987b) Anoxia reversibly suppresses neuronal Ca-currents in rat hippocampal slices. Can J Physiol Pharmacol 65: 2157–2161
Krnjevic K, Puil E and Werman R (1978a) EGTA and motoneuronal after potentials. J Physiol 275: 199–223
Lipton P and Whittingham TS (1979) The effect of hypoxia on evoked potentials in the in vitro hippocampus. J Physiol 287: 427–438
Lipton P and Whittingham TS (1984) Engery metabolism and brain slice function. In: Dingledine R (ed). Brain slices. Plenum Press New York: 113–153
Morris ME, Krnjevic K and Leblond J (1987) Changes in extracellular [K+] and [Ca2+] evoked by anoxia in rat hippocampal slices. Soc Neurosci Abstr 13: 1355
Noma A (1983) ATP-regulated K+ channels in cardiac muscle. Nature 305: 147–148
Noma A and Shibasaki T (1985) Membrane current through adenosine- triphophate-regulated potassium channels in guinea-pig ventricular cells. J Physiol 363: 463–480
Porter EL (1912) Variations in irritability of the reflex arc. Variations under asphyxial conditions, with blood-gas determinations. Amer. J Physiol 31: 223–244
Sanchez-Prieto J, Sihra TS and Nicholls DG (1987) Characterization of the exocytotic release of glutamate from guinea-pig cerebral cortical synaptosomes. J Neurochem 49: 58–64
Speckmann E-J, Caspers H and Sokolov H (1970) Aktivitätsänderungen spinaler Neurone während und nach einer Asphyxie. Pflügers Arch 319 122–138
Spruce AE, Standen NB and Stanfield PR (1985) Voltage-dependent ATP- sensitive potassium channels of skeletal muscle membrane. Nature 316: 736–738
Sugar O and Gerard RW (1938) Anoxia and brain potentials. J. Neurophysiol 1: 558–572
Trübe G, Rorsman P and Ohno-Shosaku T (1986) Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflügers Arch 407: 493–499
van Harreveld, A (1944) Survival of reflex contraction and inhibition during cord asphyxiation. Amer J Physiol 141: 97–101
Verworn M (1900) Ermüdung, Erschöpfung und Erholung der nervösen Centra des Rückenmarkes. Arch f (Anat) Physiol 1900 (Suppl): 152–176
Yamamoto C and Kurokawa M (1970) Synaptic potentials recorded in brain slices and their modification by changes in the level of tissue ATP. Exp Brain Res 10: 159–170
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© 1988 Springer-Verlag Berlin Heidelberg
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Krnjević, K., Leblond, J. (1988). Mechanisms of Failure of Synaptic Transmission During Anoxia. In: Zimmermann, H. (eds) Cellular and Molecular Basis of Synaptic Transmission. NATO ASI Series, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73172-3_18
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DOI: https://doi.org/10.1007/978-3-642-73172-3_18
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