Abstract
In healthy subjects, Na+ and Ch- contribute about 80% of extracellular osmolarity. Thus, the fraction of water distributed in the extracellular space is in large part determined by the body’s content of NaCl (salt), Most importantly, the NaCl balance influences the plasma volume, which in turn determines the atrial pressure. Since the filling of the cardiac ventricles is dependent on the atrial pressure (see Chap. 90), cardiac output is influenced by the balance of water and NaCl.
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Lang, F. (1996). Na+ Cl- and Water Metabolism. In: Greger, R., Windhorst, U. (eds) Comprehensive Human Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60946-6_78
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