Skip to main content

Na+ Cl- and Water Metabolism

  • Chapter
Comprehensive Human Physiology
  • 63 Accesses

Abstract

In healthy subjects, Na+ and Ch- contribute about 80% of extracellular osmolarity. Thus, the fraction of water distributed in the extracellular space is in large part determined by the body’s content of NaCl (salt), Most importantly, the NaCl balance influences the plasma volume, which in turn determines the atrial pressure. Since the filling of the cardiac ventricles is dependent on the atrial pressure (see Chap. 90), cardiac output is influenced by the balance of water and NaCl.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 349.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 449.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aperia A, Bertorello A, Seri I (1987) Dopamine causes inhibition of Na+, K+-ATPase activity in proximal tubular segments. Am J Physiol 252:F32–F45

    Google Scholar 

  2. Ballermann BJ, Zeidel ML (1992) Atrial natriuretic hormone. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 1843–1884

    Google Scholar 

  3. Benos DJ, Sorscher EJ (1992) Transport proteins: ion channels. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 587–624

    Google Scholar 

  4. Berns AS, Schrier RW (1981) The kidney in heart failure. In: Suki WN, Eknoyan G (eds) The kidney in systemic disease, 2nd edn. Wiley, New York, pp 569–593

    Google Scholar 

  5. Bertorello A, Hökfelt T, Goldstein M, Aperia A (1988) Proximal tubule Na+, K+-ATPase activity is inhibited during high-salt diet: evidence for DA-mediated effect. Am J Physiol 254:F795–F801

    PubMed  CAS  Google Scholar 

  6. Bichet DG, Kluge R, Howard RL, Schrier RW (1992) Hyponatremic states. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 1727–1752

    Google Scholar 

  7. Blaustein MP (1993) Physiological effects of endogenous ouabain: control of intracellular Ca2+ stores and cell responsiveness. Am J Physiol 264:C1367-C1387

    PubMed  CAS  Google Scholar 

  8. Briggs JP, Schnermann J (1986) Macula densa control of renin secretion and glomerular vascular tone: evidence for common cellular mechanisms. Renal Physiol 9:193–203

    PubMed  CAS  Google Scholar 

  9. Carey RM, Van Loon GR, Baines AD, Ortt EM (1981) Decreased plasma and urinary dopamine during dietary sodium depletion in man. J Clin Endocrinol Metab 52:903–909

    Article  PubMed  CAS  Google Scholar 

  10. Cogan MG (1990) Renal effects of atrial natriuretic factor. Annu Rev Physiol 52:699–708

    Article  PubMed  CAS  Google Scholar 

  11. Cohen HJ, Marsh DJ, Kayser B (1983) Autoregulation in vasa recta of the rat kidney. Am J Physiol 245:F32–F40

    PubMed  CAS  Google Scholar 

  12. Daly JJ, Roe RW, Horrocks PA (1967) Comparison of sodium excretion following the infusion of saline into systemic and portal veins in the dog: evidence for a hepatic role in the control of sodium excretion. Clin Sci 33:481–487

    PubMed  CAS  Google Scholar 

  13. de Torrente A, Robertson G, McDonald KM, Schrier RW (1975) Mechanism of diuretic response to increased left atrial pressure in the anethetized dog. Kidney Int 8:355–361

    Article  PubMed  Google Scholar 

  14. DeFronzo RA (1981) The effect of insulin on renal sodium metabolism. A review with clinical implications. Diabetologia 21:165–171

    Article  PubMed  CAS  Google Scholar 

  15. Denton D (1982) The hunger for salt. An anthropological, physiological and medical analysis. Springer, Berlin Heidelberg, New York

    Google Scholar 

  16. DeWeer P (1992) Cellular sodium-potassium transport. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 93–112

    Google Scholar 

  17. Edwards BS, Zimmerman RS, Schwab TR, Heublein DM, Burnett JC Jr (1988) Atrial stretch, not pressure, is the principal determinant controlling the acute release of atrial natriuretic factor. Circ Res 62:191–195

    Article  PubMed  CAS  Google Scholar 

  18. Epstein M (1976) Cardiovascular and renal effects of head-out water immersion in man. Circ Res 39:619

    Article  PubMed  CAS  Google Scholar 

  19. Fadem SZ, Hernandez-Llamas G, Patak RV, Rosenblatt SG, Lifschitz MD, Stein JH (1982) Studies on the mechanism of sodium excretion during drug-induced vasodilatation in the dog. J Clin Invest 69:604–610

    Article  PubMed  CAS  Google Scholar 

  20. Felder CC, Campbell T, Jose PA (1989) Role of cAMP on dopamine-1 receptor regulated Na+-H+ antiport in renal tubular brush border membrane vesicles. Kidney Int 35:172

    Google Scholar 

  21. Fitzsimons JT (1992) Physiology and pathophysiology of thirst and sodium appetite. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 1615–1648

    Google Scholar 

  22. Folkow B (1979) Relevance of cardiovascular reflexes. In: Hainsworth R, Kidd C, Linden RJ (eds) Cardiac receptors. Cambridge University Press, Cambridge, pp 473–505

    Google Scholar 

  23. Fozzard HA, Shorofsky SR (1992) Excitable membranes. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 407–446

    Google Scholar 

  24. Genets J, Cantin M (1988) The atrial natriuretic factor: its physiology and biochemistry. Rev Physiol Biochem Pharmacol 110:1–145

    Article  Google Scholar 

  25. Gilmore JP, Nemeth MN (1984) Salt depletion inhibits cerebral-induced natriuresis in the dog. Am J Physiol 247:F725–F728

    PubMed  CAS  Google Scholar 

  26. Gonzalez-Campoy JM, Knox FG (1992) Integrated responses of the kidney to alterations in extracellular fluid volume. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 2041–2098

    Google Scholar 

  27. Grantham JJ, Orloff J (1968) Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3′–5′-monophosphate, and theophylline. J Clin Invest 47:1154–1161

    Article  PubMed  CAS  Google Scholar 

  28. Greger R (1985) Ion transport mechanisms in thick ascending limb of Henle’s loop of mammalian nephron. Physiol Rev 65:760–797

    PubMed  CAS  Google Scholar 

  29. Haberich FJ, Aziz O, Nowacki PE, Ohm W (1969) Zur Spezifität der Osmoreceptoren in der Leber. Pflugers Arch 313:289–299

    Article  PubMed  CAS  Google Scholar 

  30. Häberle DA (1988) Hemodynamic interactions between intrinsic blood flow control mechanisms in the rat kidney. Renal Physiol Biochem 11:289–315

    PubMed  Google Scholar 

  31. Hall JE, Brands MW (1992) The renin-angiotensin-aldosterone systems: renal mechanisms and circulatory homeostasis. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 1455–1504

    Google Scholar 

  32. Hallbrucker C, vom Dahl S, Ritter M, Lang F, Häussinger D (1994) Effects of hyperosmolar urea on K+ fluxes, cell volume and hepatocellular function in perfused rat liver. Pflugers Arch 428:552–560

    Article  PubMed  CAS  Google Scholar 

  33. Horisberger JD, Lemas V, Kraehenbühl JP, Rossier BC (1991) Structure-function relationship of the Na, K-ATPase. Annu Rev Physiol 53:565–584

    Article  PubMed  CAS  Google Scholar 

  34. Howard RL, Bichet DG, Schrier RW (1992) Hypernatremic and polyuric states. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 1753–1778

    Google Scholar 

  35. Ichikawa I, Brenner BM (1979) Mechanism of inhibition of proximal tubule fluid reabsorption after exposure of the rat kidney to the physical effects of expansion of extracellular fluid volume. J Clin Invest 64:1466–1474

    Article  PubMed  CAS  Google Scholar 

  36. Illowsky BP, Kirch DG (1988) Polydipsia and hyponatremia in psychiatric patients. Am J Psychiatry 145:675–683

    PubMed  CAS  Google Scholar 

  37. Jose CJ, Perez-Cruet J (1979) Incidence and morbidity of self-induced water intoxication in state mental hospital patients. Am J Psychiatry 136:221–222

    PubMed  CAS  Google Scholar 

  38. Kirk KL, Schafer JA (1992) Water transport and osmoregulation by antidiuretic hormone in terminal nephron segments. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 1693–1726

    Google Scholar 

  39. Koh GY, Klug MG, Field LJ (1993) Atrial natriuretic factor and transgenic mice. Hypertension 22:634–639

    Article  PubMed  CAS  Google Scholar 

  40. Krapf R (1989) Physiology and molecular biology of the renal Na/H antiporter. Klin Wochenschr 67:847–851

    Article  PubMed  CAS  Google Scholar 

  41. Kurtzman NA, White MG, Rogers PW (1973) Pathophysiology of metabolic alkalosis. Arch Intern Med 131:703–708

    Google Scholar 

  42. Lang F (1987) Osmotic diuresis. Renal Physiol 10:160–173

    PubMed  CAS  Google Scholar 

  43. Lang F, Rehwald W (1992) Potassium channels in renal epithelial transport regulation. Am J Physiol 72:1–32

    CAS  Google Scholar 

  44. Lang F, Messner G, Rehwald W (1986) Electrophysiology of sodium-coupled transport in proximal renal tubules. Am J Physiol 250:F953–F962

    PubMed  CAS  Google Scholar 

  45. Lang F, Völkl H, Häussinger D (1990) General principles in cell volume regulation. In: Beyenbach KW (ed) Cell volume regulation. Comparative physiology. Karger, Basel, pp 1–25

    Google Scholar 

  46. Lang F, Häussinger D, Tschernko E, Capasso G, DeSanto NG (1992) Proteins, the liver and the kidney — hepatic regulation of renal function. Nephron 61:1–4

    Article  PubMed  CAS  Google Scholar 

  47. Lang F, Tschernko E, Häussinger D (1992) Hepatic regulation of renal function. Exp Physiol 77:663–673

    PubMed  CAS  Google Scholar 

  48. Lang F, Gerok W, Häussinger D (1993) New clues to the pathophysiology of hepatorenal failure. Clin Invest 71:93–97

    Article  CAS  Google Scholar 

  49. Laragh JH (1992) The renin system and the renal regulation of blood pressure. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 1411–1454

    Google Scholar 

  50. Mancia G, Donald DE (1975) Demonstration that the atria, ventricles, and lungs each are responsible for a tonic inhibition of the vasomotor center in the dog. Circ Res 36:310–318

    Article  PubMed  CAS  Google Scholar 

  51. Mancia G, Ferrari A, Gregorini L, Parati G, Pomidossi G, Zanchetti A (1979) Control of blood pressure by carotid sinus baroreceptors in human beings. Am J Cardiol 44:895–902

    Article  PubMed  CAS  Google Scholar 

  52. Marchand GR (1978) Interstitial pressure during volume expansion at reduced renal artery pressure. Am J Physiol 235:F209–F212

    PubMed  CAS  Google Scholar 

  53. McGiff JC, Schwartzman M, Ferreri NR (1985) Renal prostaglandins and hypertension. Adv Prostaglandin Thromboxane Leukotriene Res 13:161–169

    CAS  Google Scholar 

  54. Moncada S, Palmer MRJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109–142

    PubMed  CAS  Google Scholar 

  55. Muto S, Tabei K, Asano Y, Imai M (1985) Dopaminergic inhibition of the action of vasopression on the cortical collecting tubule. Eur J Pharmacol 114:393–397

    Article  PubMed  CAS  Google Scholar 

  56. Oberleithner H (1991) Acute aldosterone action in renal target cells. Cell Physiol Biochem 1:2–12

    Article  CAS  Google Scholar 

  57. Osswald H, Spielman WS, Knox FG (1978) Mechanism of adenosine mediated decrease in glomerular filtration rate. Circ Res 43:465–469

    Article  PubMed  CAS  Google Scholar 

  58. Osswald H, Hermes HH, Nabakowski G (1982) Role of adenosine in signal transmission of tubuloglomerular feedback. Kidney Int 22 Suppl 12:S136–S142

    Google Scholar 

  59. Paintal AS (1973) Vagal sensory receptors and their reflex effects. Physiol Rev 53:159–226

    PubMed  CAS  Google Scholar 

  60. Palmer BF, Alpern RJ, Seldin DW (1992) Pathophysiology of edema formation. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 2099–2141

    Google Scholar 

  61. Palmer LG (1992) Epithelial Na channels: function and diversity. Annu Rev Physiol 54:51–66

    Article  PubMed  CAS  Google Scholar 

  62. Reeves WB, Andreoli TE (1992) Sodium chloride transport in the loop of Henle. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 1975–2002

    Google Scholar 

  63. Robertson GL (1977) Vasopressin function in health and disease. Recent Prog Horm Res 33:333–385

    Google Scholar 

  64. Robertson GL (1983) Thirst and vasopressin function in normal and disordered states of water balance. J Lab Clin Med 101:351–371

    PubMed  CAS  Google Scholar 

  65. Robertson GL (1992) Regulation of vasopressin secretion. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 1595–1614

    Google Scholar 

  66. Romero JC, Knox FG (1988) Mechanisms underlying pressure-related natriuresis: the role of the renin-angiotensin and prostaglandin systems. Hypertension 11:724–738

    Article  PubMed  CAS  Google Scholar 

  67. Roy DR, Layton HE, Jamison RL (1992) Countercurrent mechanism and its regulation. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 1649–1692

    Google Scholar 

  68. Saeki Y, Terui N, Kumada M (1988) Physiological characterization of the renal-sympathetic reflex in rabbits. Jpn J Physiol 38:251–266

    Article  PubMed  CAS  Google Scholar 

  69. Sardet C, Wakayabashi S, Fafournoux P, Counillon L, Pages G, Pouyssegur J (1991) Molecular properties of Na+/H+ exchanges. In: DeSanto NG, Capasso G (eds) Acid-base balance. Bios, Cosenza, pp 13–20

    Google Scholar 

  70. Schad H, Seller H (1976) Reduction of renal nerve activity by volume expansion in conscious cats. Pflugers Arch 363:155

    Article  PubMed  CAS  Google Scholar 

  71. Schlatter E (1989) Antidiuretic hormone regulation of electrolyte transport in the distal nephron. Renal Physiol Biochem 12:65–84

    PubMed  CAS  Google Scholar 

  72. Schnermann J, Briggs JP (1992) Function of the juxtaglomerular apparatus: control of glomerular hemodynamics and renin secretion. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Rave, New York, pp 1249–1290

    Google Scholar 

  73. Sebastian A, McSherry E, Morris RC Jr (1971) On the mechanism of renal potassium wasting in renal tubular acidosis associated with the Fanconi syndrome (type 2 RTA). J Clin Invest 50:231–243

    Article  PubMed  CAS  Google Scholar 

  74. Skinner SL, McCubbin JW, Page IH (1964) Control of renin secretion. Circ Res 15:64

    Article  PubMed  CAS  Google Scholar 

  75. Smith PR, Benos DJ (1991) Epithelial Na+ Channels. Annu Rev Physiol 53:509–530

    Article  PubMed  CAS  Google Scholar 

  76. Spyer KM (1981) The neural organization and control of the baroreflex. Rev Physiol Biochem Exp Pharmacol 88:23–124

    Article  Google Scholar 

  77. Stella A, Golin R, Genovesi S, Zanchetti A (1987) Renal reflexes in the regulation of blood pressure and sodium excretion. Can J Physiol Pharmacol 65:1536–1539

    Article  PubMed  CAS  Google Scholar 

  78. Szatalowicz VL, Arnold PE, Chaimovitz C, Bichet D, Bed T, Schrier RW (1981) Radioimmunoassay of plasma arginine vasopressin in hyponatremic patients with congestive heart failure. N Engl J Med 305:263–266

    Article  PubMed  CAS  Google Scholar 

  79. Thames MD, Jarecki M, Donald DE (1978) Neural control of renin secretion in anesthetized dogs. Interaction of cardiopulmonary and carotid baroreceptors. Circ Res 42:237–245

    Article  PubMed  CAS  Google Scholar 

  80. Toto RD, Seldin DW (1992) Salt wastage. In: Seldin DW, Giebisch G (eds) The kidney. Physiology and pathophysiology, 2nd edn. Raven, New York, pp 2143–2164

    Google Scholar 

  81. Uranga J, Fuenzalida R, Rapoport AL, Del Castillo E (1979) Effect of glucagon and glomerulopressin on the renal function of the dog. Horm Metab Res 11:275–279

    Article  PubMed  CAS  Google Scholar 

  82. Weisinger RS, Considine P, Denton DA, McKinley M, Leksell L, McKinley MJ, Mouw DR, Muller AF, Tarjan E (1982) Role of the sodium concentration of the cerebrospinal fluid in the salt appetite of sheep. Am J Physiol 242:R51–R63

    PubMed  CAS  Google Scholar 

  83. Wolf AV (1950) Osmometric analysis of thirst in man and dog. Am J Physiol 161:75–86

    PubMed  CAS  Google Scholar 

  84. Wuthrich RP, Valloton M (1986) Prostaglandin E2 and cyclic AMP response to vasopressin in renal medullary tubular cells. Am J Physiol 251:F499–F505

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Lang, F. (1996). Na+ Cl- and Water Metabolism. In: Greger, R., Windhorst, U. (eds) Comprehensive Human Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60946-6_78

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60946-6_78

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64619-5

  • Online ISBN: 978-3-642-60946-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics