Summary
In conscious cats with intact or denervated baroreceptors volume expansion of 5–15% of blood volume was, performed with dextran and isotonic sodium chloride. Renal sympathetic activity (RSA), electroencephalogram (EEG) blood pressure (BP) and heart rate (HR) were recorded. RSA was reduced by 25–85% in 10 experiments out of 11 by volume expansion both with dextran and isotonic sodium chloride. Reduction of RSA could not be related to different states of wakefulness as indicated by the EFG, so could only be caused by volume expansion, although no quantitative correlation could be detected. No differences were observed between animals with intact and denervated baroreceptors. In most experiments BP and HR decreased during volume expansion up to −25 mm Hg and up to −23 beats/min, respectively. The degree of BP and HR reduction could not be related to the degree of RSA reduction. The results suggest that changes in RSA might be involvec in the renal response to volume expansion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Baust, W., Weidinger, H., Kirchner, F.: Sympathetic activity during natural sleep and arousal. Arch. ital. Biol.106, 379–390 (1968)
Chapman, L. W., Mittmann, U., Meehan, J. P.: Neural effect of cardiac receptors on renal salt excretion. Fed. Proc.30, 608 (1971)
Clement, D. L., Pelletier, C. L., Shepherd, J. T.: Role of vagal afferents in the control of renal sympathetic nerve activity in the rabbit. Girculat. Res.31, 824–830 (1972)
Dieter, E.: Der Einfluß der Kreislauffüllung auf die Aktivität der Nierennerven beim Frosch. Pflügers Arch. ges. Physiol.270, 215–226 (1960)
Edis, A. J., Donald, D. E., Shepherd, J. T.: Cardiovascular reflexes from stretch of pulmonary vein—atrial junctions in the dog. Circulat. Res.27, 1091–1100 (1970)
Gill, J. R., Jr., Caspar, A. G. T.: Role of the sympathetic nervous system in the renal response to hemorrhage. J. clin. Invest.48, 915–922 (1969)
Gillespie, D. J., Sandberg, R. L., Koike, T. I.: Dual effect of left atrial receptors on excretion of sodium and water in the dog. Amer. J. Physiol.225, 706–710 (1973)
Gilmore, J. P., Zucker, I. H.: Discharge of type B atrial receptors during changes in vascular volume and depression of atrial contractility. J. Physiol. (Lond.)239, 207–223 (1974)
Goetz, K. L., Hermreck, A. S., Slick, G. L., Starke, H. S.: Atrial recptors and renal function in conscious dogs. Amer. J. Physiol.219, 1417–1422 (1970)
Gupta, P. D., Henry, J. P., Sinclair, R., von Baumgarten, R.: Responses of atrial and aortic baroreceptors to nonhypotensive hemorrhage and to transfusion. Amer. J. Physiol.211, 1429–1437 (1966)
Hakumäki, M. O. K.: Function of the left atrial receptors. Acta physiol. scand.79, Suppl. 344, 1–54 (1970)
Kahl, F. R., Flint, J. F., Szidon, J. P.: Influence of left atrial distension on renal vasomotor tone. Amer. J. Physiol.226, 240–246 (1974)
Kappagoda, C. T., Linden, R. J., Snow, H. M.: Reflex increase in heart rate from distension of the junction between the superior vena cava and the right atrium. J. Physiol. (Lond.)220, 177–197 (1972)
Kappagoda, C. T., Linden, R. J., Snow, H. M., Whitaker, E. M.: Effect of destruction of the posterior pituitary on the diuresis from left atrial receptors. J. Physiol. (Lond.)244, 757–770 (1975)
Karim, F., Kidd, C., Malpus, C. M., Penna, P. E.: The effects of stimulation of the left atrial receptors on sympathetic efferent nerve activity. J. Physiol. (Lond.)227, 243–260 (1972)
Kirchner, F.: Correlations between changes of activity of the renal sympathetic nerve and behavioural events in unrestrained cats. Basic Res. Cardiol.69, 243–256 (1974)
Ledsome, J. R., Linden, R. J.: A reflex increase in heart rate from distension of the pulmonary vein—atrial junctions. J. Physiol. (Lond.)170, 456–473 (1964)
Ledsome, J. R., Mason, J. M.: The effects of vasopressin on the diuretic response to left atrial distension. J. Physiol. (Lond.)221, 427–440 (1972)
Pearce, J. W.: Renal nervous and spinal pathways and the reflex regulation of extracellular fluid volume. Fed. Proc.27, 1142–1148 (1968)
Schad, H., Seller, H.: Influence of intracranical osmotic stimuli on renal nerve activity in anaesthetized cats. Pflügers Arch.353, 107–121 (1975)
Schad, H., Seller, H.: A method for recording autonomic nerve activity in unanaesthetized, freely moving cats. Brain Res.100, 425–430 (1975)
Zehr, J. E., Johnson, J. A., Moore, W. W.: Left atrial pressure, plasma osmolatily, and ADH levels in the unanaesthetized ewe. Amer. J. Physiol.217, 1672–1680 (1969)
Author information
Authors and Affiliations
Additional information
Supported by the Deutsche Forschungsgemeinschaft.
Rights and permissions
About this article
Cite this article
Schad, H., Seller, H. Reduction of renal nerve activity by volume expansion in conscious cats. Pflugers Arch. 363, 155–159 (1976). https://doi.org/10.1007/BF01062284
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01062284