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Roles of Anti-αGal Antibody and Oligosaccharide Therapy in Xenotransplantation

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Xenotransplantation

Abstract

It is now generally agreed that the hyperacute rejection (HAR) of pig organs by both human and nonhuman primates is related to the presence of preformed “natural” antibodies in the host [1–4]. The true origin of these antibodies is speculative, but they develop within a few weeks after birth, probably as soon as the neonate’s gastrointestinal tract becomes colonized by microorganisms [5, 6]. The antibody-antigen reaction that takes place on the surface of the vascular endothelium stimulates the complement cascade and “activates” the endothelial cells [7], leading to endothelial cell damage with capillary disruption and interstitial hemorrhage [8], resulting in rapid destruction of the tissues with loss of function.

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Authors
  1. F. A. Neethling
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  2. S. Taniguchi
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  3. S. F. Li
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  4. E. Koren
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  5. R. Oriol
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  6. R. D. Cummings
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  7. D. K. C. Cooper
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Editor information

Editors and Affiliations

  1. Immunologist (Surgery), Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 02129, Boston, Massachusetts, USA

    David K. C. Cooper M.A., M.D., Ph.D., M.S., F.R.C.S. (Associate Member, Scientific Staff) (Associate Member, Scientific Staff)

  2. Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

    David K. C. Cooper M.A., M.D., Ph.D., M.S., F.R.C.S. (Associate Member, Scientific Staff) (Associate Member, Scientific Staff)

  3. Department of Nephrology, Odense University Hospital, 5000, Odense, Denmark

    Ejvind Kemp M.D. (Professor and Head) (Professor and Head)

  4. Departments of Surgery, Pediatrics and Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    Jeffrey L. Platt M.D. (Joseph W. and Dorothy W. Beard Professor) (Joseph W. and Dorothy W. Beard Professor)

  5. Department of Surgery, University of Cambridge, Cambridge, CB22QQ, UK

    David J. G. White M.A., Ph.D., M.R.C.Path (Immunologist and Lecturer, Director of Research and Development) (Immunologist and Lecturer, Director of Research and Development)

  6. Imutran Laboratories, Cambridge, UK

    David J. G. White M.A., Ph.D., M.R.C.Path (Immunologist and Lecturer, Director of Research and Development) (Immunologist and Lecturer, Director of Research and Development)

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© 1997 Springer-Verlag Berlin Heidelberg

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Neethling, F.A. et al. (1997). Roles of Anti-αGal Antibody and Oligosaccharide Therapy in Xenotransplantation. In: Cooper, D.K.C., Kemp, E., Platt, J.L., White, D.J.G. (eds) Xenotransplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60572-7_25

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  • DOI: https://doi.org/10.1007/978-3-642-60572-7_25

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  • Online ISBN: 978-3-642-60572-7

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