Skip to main content

Brain tumors

  • Chapter
PET in Clinical Oncology
  • 151 Accesses

Abstract

Brain tumors are relatively rare: in post-mortem statistics, their incidence is approximately 6.7% in Eastern Germany and between 2.2 and 15.8% in other countries (for a review, see [68]). Only between 1 and 4% of all malignancies in adults are brain tumors. In children, the percentage is higher, ranging between 20 and 25%.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Alavi JB, Alavi A, Goldberg HI, Dann R, Hickey W, Reivich M (1987) Sequential CT and PET studies in a patient with malignant glioma. Nucl Med Commun 8:457–468

    Article  PubMed  CAS  Google Scholar 

  2. Alavi JB, Alavi A, Chawluk J, Kushner M, Powe J, Hickey W, Reivich M (1988) Positron emission tomography in patients with glioma - a predictor of prognosis. Cancer 62:1074–1078

    Article  PubMed  CAS  Google Scholar 

  3. Barker FG, Chang SM, Valk PE, Pounds TR, Prados MD (1997) 18 Fluorodeoxyglucose uptake and survival of patients with suspected recurrent malignant glioma. Cancer 79:115–126

    Article  PubMed  CAS  Google Scholar 

  4. Bergström M, Collins VP, Ehrin E, Ericson K, Eriksson L, Greitz T, Halldin C, von Holst H, Langström B, Lilja A, Lundqvist H, Nagren K (1983) Discrepancies in brain tumor extent as shown by computed tomography and positron emission tomography using [68GA] EDTA, [11C] glucose and [11C] methionine. J Comput Assist Tomogr 7:1062–1066

    Article  PubMed  Google Scholar 

  5. Black KL, Hawkins RA, Kim KT, Becker DP, Lerner C, Marciano D (1989) Use of thallium-201 SPECT to quantitate malignancy grade of gliomas. J Neurosurg 71:342–346

    Article  PubMed  CAS  Google Scholar 

  6. Black KL, Emerick T, Hoh C, Hawkins RA, Mazziotta J, Becker DP (1994) Thallium-201 SPECT and positron emission tomography equal predictors of glioma grade and recurrence. Neurol Res 16:93–96

    PubMed  CAS  Google Scholar 

  7. Borbely K, Fulham MJ, Brooks RA, Di Chiro G (1992) PET-fluorodeoxyglucose of cranial and spinal neuromas. J Nucl Med 33:1931–1934

    PubMed  CAS  Google Scholar 

  8. Brucher JM (1993) Neuropathological diagnosis with stereotactic biopsies. Possibilities, difficulties and requirements. Acta Neurochir 124:37–39

    Article  CAS  Google Scholar 

  9. Byrne TN (1994) Imaging of gliomas. Semin Oncol 21:162–171

    PubMed  CAS  Google Scholar 

  10. Carvalho PA, Schwartz RB, Eben A et al. (1992) Detection of recurrent gliomas with quantitative thallium-201/technetium-99m HMPAO single-photon emission computerized tomography. J Neurosurg 77:565–570

    Article  PubMed  CAS  Google Scholar 

  11. Chandrasoma PT, Smith MM, Appuzzo MLJ (1989) Stereotactic biopsy in the diagnosis of brain masses: comparison of results of biopsy and resected surgical specimen. Neurosurgery 24:160–165

    Article  PubMed  CAS  Google Scholar 

  12. Chang LT (1978) A method for attenuation correction in radionuclide computed tomography. IEEE Trans Nucl Sci NS-26/2:2780–2789

    Article  Google Scholar 

  13. Cremerius U, Striepecke E, Henn W, Weis J, Mull M, Lippitz B, Gilsbach J, Schröder JM, Zang KD, Böcking A, Bull U (1994) 18FDG-PET in intracranial meningeomas versus grading, proliferation index, cellular density, and cytogenetic analysis. Nuklearmedizin 33:144–149

    PubMed  CAS  Google Scholar 

  14. De Souza B, Brunetti A, Fulham MJ, Brooks RA, DeMichele D, Cook P, Nieman L, Doppman JL, Oldfield EH, Di Chiro G (1990) Pituitary microadenomas: a PET study. Radiology 177:39–44

    PubMed  Google Scholar 

  15. De Witte O, Levivier M, Violon P, Salmon S, Damhaut P, Wikler D, Hildebrand J, Brotchi J, Goldman S (1996) Prognostic value of positron emission tomography with [18] fluorodeoxyglucose in the low-grade glioma. Neurosurgery 39:470–477

    PubMed  Google Scholar 

  16. Delbeke D, Meyerowitz C, Lapidus RL, Maciunas RJ, Jennings MT, Moots PL, Kessler RM (1995) Optimal cutoff levels of F-18 fluorodeoxyglucose uptake in the differentiation of low-grade from high-grade brain tumors with PET. Radiology 195:47–52

    PubMed  CAS  Google Scholar 

  17. Derlon JM, Bourdet C, Bustany P et al. (1989) [11C] L-Methionine uptake in gliomas. Neurosurgery 30:225–232

    Google Scholar 

  18. Di Chiro G, Oldfield E, Wright DC, De Michele D, Katz DA, Patronas NJ, Doppman JL, Larson SM, Ito M, Kufta CV (1988) Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathological studies. AJR 150:189–197

    PubMed  Google Scholar 

  19. Di Chiro G (1986) Positron emission tomography using [18F] fluorodeoxyglucose in brain tumors: a powerful diagnostic and prognostic tool. Invest Radiol 22:360–371

    Article  Google Scholar 

  20. Di Chiro G, Hatazawa J, Katz DA, Rizzoli HV, De Michele DJ (1987) Glucose utilization by intracranial meningeomas as an index of tumor aggressivity and probability of recurrence: a PET study. Radiology 164:521–526

    PubMed  Google Scholar 

  21. Doyle WK, Budinger TF, Valk PE, Levin VA, Gutin PH (1987) Differentiation of cerebral radiation necrosis from tumor recurrence by [18F1 FDG and 82Rb positron emission tomography. J Comput Assist Tomogr 11:563–570

    Article  PubMed  CAS  Google Scholar 

  22. Ericson K, Lilja A, Bergström M, Collins VP, Eriksson L, Ehrin E, von Holst H, Lundqvist H, Langström B, Mosskin M (1985) Positron emission tomography with ([11C] methyl)-L-methionine, [11C] D-glucose, and [68GA] EDTA in supratentorial brain tumors. J Comput Assist Tomogr 9:683–689

    Article  PubMed  CAS  Google Scholar 

  23. Francavilla TL, Miletich RS, Di Chiro G, Patronas NJ, Rizzoli HV, Wright DC (1989) Positron emission tomography in the detection of malignant degeneration of low-grade gliomas. Neurosurgery 24:1–5

    Article  PubMed  CAS  Google Scholar 

  24. Glantz MJ, Hoffman JM, Coleman RE, Friedman AH, Hanson MW, Burger PC, Herndon JE II, Meisler WJ, Schold SC (1991) Identification of early recurrence of primary central nervous system tumors by [18F] fluorodeoxyglucose positron emission tomography. Ann Neurol 29:347–355

    Article  PubMed  CAS  Google Scholar 

  25. Goldman S, Levivier M, Pirotte B, Brucher J-M, Wikler D, Damhaut P, Stanus E, Brotchi J, Hildebrand J (1996) Regional glucose metabolism and histopathology of gliomas. Cancer 78:1098–1106

    Article  PubMed  CAS  Google Scholar 

  26. Goldman S, Levivier M, Pirotte B, Brucher J-M, Wikler D, Damhaut P, Dethy S, Brotchi J, Hildebrand J (1997) Regional methionine and glucose uptake in high-grade gliomas: a comparative study on PET-guided stereotactic biopsy. J Nucl Med 38:1459–1462

    PubMed  CAS  Google Scholar 

  27. Griffeth LK, Rich KM, Dehdashti F, Simpson JR, Fusselman MJ, McGuire AH, Siegel BA (1993) Brain metastases from non-central nervous system tumors: evaluation with PET [see comments]. Radiology 186:37–44

    PubMed  CAS  Google Scholar 

  28. Guth-Tougelides B, Müller St, Mehdorn MM, Knust EJ, Dutschka K, Reiners C (1995) Anreicherung von DL-3-123I-Jod-Methyltyrosin in Hirntumorrezidiven. Nuklearmedizin 34:71–75

    Google Scholar 

  29. Herholz K, Pietrzyk U, Voges J, Schröder R, Halber M, Treuer H, Sturm V, Heiss W-D (1993) Correlation of glucose consumption and tumor cell density in astrocytomas. A stereotactic PET study. J Neurosurg 79:853–858

    Article  PubMed  CAS  Google Scholar 

  30. Heiss P, Mayer S, Herz M, Wester HJ, Schwaiger M, Senekowitsch-Schmidtke R (1999) Investigation of transport mechanism and uptake kinetics of O-(2-[18F]fluoroethyl)L-tyrosine in vitro and in vivo. J Nucl Med 40:1367–173

    PubMed  CAS  Google Scholar 

  31. Herholz K, Hölzer T, Bauer B, Schröder R, Voges J, Ernestus RI, Mendoza G, WeberLuxenburger G, Löttgen J, Thiel A, Wienhard K, Heiss W-D (1998) C-11-Methionine PET for differential diagnosis of low-grade gliomas. Neurology 50:1316–1322

    Article  PubMed  CAS  Google Scholar 

  32. Hoffman JM, Waskin HA, Schifter T, Widemann B, Schröder R, Neubauer I, Heiss WD (1993) FDG-PET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS. J Nucl Med 34:567–575

    PubMed  CAS  Google Scholar 

  33. Holthoff VA, Herholz K, Berthold F, Widemann B, Schröder R, Neubauer I, Heiss WD (1993) In vivo metabolism of childhood posterior fossa tumors and primitive neuroectodermal tumors before and after treatment. Cancer 72:1394–1403

    Article  PubMed  CAS  Google Scholar 

  34. Holzer T, Herholz K, Jeske J, Heiss WD (1993) FDG-PET as a prognostic indicator in radiochemotherapy of glioblastoma. J Comput Assist Tomogr 17:681–687

    Article  PubMed  CAS  Google Scholar 

  35. Inoue T, Shibasaki T, Oriuchi N, Aoyagi K, Tomiyoshi K, Amano S, Mikuni M, Ida I, Aoki J, Endo K (1999) 18F alpha-methyl tyrosine PET studies in patients with brain tumors. J Nucl Med 40:399–405

    PubMed  CAS  Google Scholar 

  36. Inoue T, Tomiyoshi K, Higuichi T, Ahmed K, Sarwar M, Aoyagi K, Amano S, Alyafei S, Zhang H, Endo K (1998) Biodistribution studies on L-3-[fluorine-18]fluoro-alphamethyl tyrosine: a potential tumor-detecting agent

    Google Scholar 

  37. Janus TJ, Kim E, Tilbury R, Bruner JM, Yung WKA (1993) Use of [18F] fluorodeoxyglucose positron emission tomography in patients with primary malignant brain tumors. Ann Neurol 33:540–548

    Article  PubMed  CAS  Google Scholar 

  38. Kahn D, Follett KA, Bushnell DL, Nathan MA, Piper JG, Madsen M, Kirchner PT (1994) Diagnosis of recurrent brain tumor: Value of 201T1 SPECT vs 18F-fluorodeoxyglucose PET. AJR 163:1450–1465

    Google Scholar 

  39. Kaschten B, Stevenaert A, Sadzot B, Deprez M, Degueldre C, Del Fiore G, Luxen A, Reznik M (1998) Pre-operative evaluation of 54 gliomas by PET with fluorine-18fluorodeoxyglucose and/or carbon-11-methionine. J Nucl Med 39:778–785

    PubMed  CAS  Google Scholar 

  40. Kim CK, Alavi JB, Alavi A, Reivich M (1991) New grading system of cerebral gliomas using positron emission tomography with F-18 fluorodeoxyglucose. J Neuro-Oncol 10:85–91

    Article  CAS  Google Scholar 

  41. Kramm CM, Sena-Esteves M, Barnett FH, Rainov NG, Schuback DE, Yu JS, Pechan PA, Paulus W, Chiocca EA, Breakefield XO (1995) Gene therapy for brain tumors. Brain Pathology 5:345–381

    Article  PubMed  CAS  Google Scholar 

  42. Kuwert T, Morgenroth C, Woesler B, Matheja P, Palkovic S, Vollet B, Samnick S, Maasjosthusmann U, Lerch H, Gildehaus F-J, Wassmann H, Schober O (1996) Uptake of iodine-123-methyl tyrosine by gliomas and non-neoplastic brain lesions. Eur J Nucl Med 23:1345–1353

    Article  PubMed  CAS  Google Scholar 

  43. Kuwert T, Bartenstein P, Grünwald F, Herholz K, Larisch R, Sabri 0, Biersack H-J, Moser E, Müller-Gärtner H-W, Schober 0, Schwaiger M, Büll U, Heiss W-D (1998) Klinische Wertigkeit der Positronen-Emissions-Tomographie in der Neuromedizin. Nervenarzt 69:1045–1060

    Article  PubMed  CAS  Google Scholar 

  44. Kuwert T, Woesler B, Morgenroth C, Lerch H, Schäfers M, Palkovic P, Matheja P, Brandau W, Wassmann H, Schober O (1998) Diagnosis of recurrent glioma with SPECT and iodine-123-methyl tyrosine. J Nucl Med 39:23–27

    PubMed  CAS  Google Scholar 

  45. Kole AC, Pruim J, Nieweg OE, van Ginkel RJ, Hoekstra HJ, Schraffordt Koops H, Vaalburg W (1997) PET with L-[1-carbon-11]-tyrosine to visualize tumors and measure protein synthesis rates. J Nucl Med 38:191–195

    PubMed  CAS  Google Scholar 

  46. Langen K-J, Roosen N, Kuwert T, Herzog H, Kiwit JC, Rota Kops E, Muzik 0, Bock WJ, Feinendegen LE (1989) Early effects of intra-arterial chemotherapy in patients with brain tumours studied with PET: preliminary results. Nucl Med Commun 10:779–790

    Article  PubMed  CAS  Google Scholar 

  47. Leeds NE, Jackson EF (1994) Current imaging techniques for the evaluation of brain neoplasms. Curr Opin Oncol 6:254–261

    Article  PubMed  CAS  Google Scholar 

  48. Levivier M, Goldman S, Pirotte B, Brucher JM, Balériaux D, Luxen A, Hildebrand J, Brotchi J (1995) Diagnostic yield of stereotactic brain biopsy guided by positron emission tomography with [18F] fluorodeoxy-glucose. J Neurosurg 82:445–452

    Article  PubMed  CAS  Google Scholar 

  49. Lilja A, Lundqvist H, Olsson Y, Spännare B, Gullberg P, Langström B (1989) Positron emission tomography and computed tomography in differential diagnosis between recurrent or residual glioma and treatment-induced brain lesions. Acta Radiol 30:121–128

    Article  PubMed  CAS  Google Scholar 

  50. Loiseau H, Bousquet P, Rivel J, Vital C, Kantor G, Rougier A, Dartigues JF, Cohadon F (1995) Astrocytomes de bas grade sustentoriels de l’adulte: Facteurs prognostics et indications thérapeutiques - á propos dune série de 141 patients. Neurochirurgie 41:38–51

    PubMed  CAS  Google Scholar 

  51. Lorberboym M, Estok L, Machac J, German I, Sacher M, Feldman R, Wallach F, Dorfman D (1996) Rapid differential diagnosis of cerebral toxoplasmosis and primary central nervous system lymphoma by thallium-201 SPECT. J Nucl Med 37:1150–1154

    PubMed  CAS  Google Scholar 

  52. Lorberboym M, Wallach F, Estok L, Mosesson RE, Sacher M, Kim CK, Machac J (1998) Thallium-201 retention in focal intracranial lesions for differential diagnosis of primary lymphoma and nonmalignant lesions in AIDS patients. J Nucl Med 39:1366–1369

    PubMed  CAS  Google Scholar 

  53. Maciunas RJ, Kessler RM, Maurer C, Mandava V, Watt G, Smith G (1992) Positron emission tomography imaging directed stereotactic neurosurgery. Stereotact Funct Neurosurg 58:134–140

    Article  PubMed  CAS  Google Scholar 

  54. Maffioli L, Gasparini M, Chiti A, Gramaglia A, Mongioj V, Pozzi A, Bombardieri E (1996) Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumors. Eur J Nucl Med 23:308–311

    Article  PubMed  CAS  Google Scholar 

  55. McCormack BM, Miller DC, Budzilovich GN, Vorhees GJ, Ransohoff J (1992) Treatment and survival of low-grade astrocytoma in adults: 1977–1988. Neurosurgery 31:636–642

    Article  PubMed  CAS  Google Scholar 

  56. Mosskin M, Ericson K, Hindmarsh T, von Holst H, Collins VP, Bergström M, Eriksson L, Johnström P (1989) Positron emission tomography compared with magnetic resonance imaging and computed tomography in supratentorial gliomas using multiple stereotactic biopsies as reference. Acta Radiol 30:225–232

    Article  PubMed  CAS  Google Scholar 

  57. Miettinen H, Kononen J, Haapasalo H, Helen P, Sallinen P, Harjuntausta T, Helin H, Alho H (1995) Expression of peripheral-type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: relationship to cell proliferation. Cancer Res 55:2691–2695

    PubMed  CAS  Google Scholar 

  58. Mineura K, Yasuda T, Kowada M, Ogawa T, Shishido F, Uemura K (1987) Positron emission tomography evaluation of radiochemotherapeutic effect on regional cerebral hemocirculation and metabolism in patients with gliomas. J Neuro-Oncol 5:277–285

    Article  CAS  Google Scholar 

  59. Nagano N, Sasaki H, Aoyagi M, Hirakawa K (1993) Invasion of experimental brain tumor: early morphological changes following microinjection of C6 glioma cells. Acta Neuropathol 86:117–125

    Article  PubMed  CAS  Google Scholar 

  60. Nariai T, Senda M, Ishii K, Maehara T, Wakabayashi S, Toyama H, Ishiwata K, Hirakawa K (1997) Three-dimensional imaging of cortical structure, function and glioma for tumor resection. J Nucl Med 38:1563–1568

    PubMed  CAS  Google Scholar 

  61. Newsholme P, Newsholme EA (1989) Rates of utilization of glucose, glutamine, and oleate and formation of end-products by mouse peritoneal macrophages in culture. Biochem J 261:211–218

    PubMed  CAS  Google Scholar 

  62. Ogawa T, Kanno I, Shishido F, Inugami A, Higano S, Fujita H, Murakami M, Uemura K, Yasui N, Mineura K, Kowada M (1991) Clinical value of PET with 18fluoro-deoxyglucose and L-methyl-11C-methionine for diagnosis of recurrent brain tumor and radiation injury. Acta Radiol 32:197–202

    Article  PubMed  CAS  Google Scholar 

  63. Ogawa T, Shishido F, Kanno I et al. (1993) Cerebral glioma: evaluation with methionine PET. Radiology 186:45–53

    PubMed  CAS  Google Scholar 

  64. Ogawa T, Shishido F, Kanno I et al. (1996) Clinical positron emission tomography for brain tumors: comparison of fluorodeoxyglucose 18F and L-methyl-11C-methionine. AJNR 17:345–353

    PubMed  CAS  Google Scholar 

  65. Olivero WC, Dulebohn SC, Lister JR (1995) The use of PET in evaluating patients with primary brain tumors: is it useful? J Neurol Neurosurg Psychiatr 58:250–252

    Article  PubMed  CAS  Google Scholar 

  66. Oriuchi N, Tomiyoshi K, Inoue T et al. (1996) Independent thallium-201 accumulation and fluorine-18-fluorodeoxyglucose metabolism in glioma. J Nucl Med 37:457–462

    PubMed  CAS  Google Scholar 

  67. Patronas NJ, Di Chiro G, Kufta C, Bairamian D, Kornblith PL, Simon R, Larson SM (1985) Prediction of survival in glioma patients by means of positron emission tomography. J Neurosurg 62:816–822

    Article  PubMed  CAS  Google Scholar 

  68. Paulus W (1995) Tumoren des Nervensystems. In: Peiffer J, Schröder JM (eds) Neuropathologie. Morphologische Diagnostik der Krankheiten des Nervensystems, der Skelettmuskulatur and der Sinnesorgane. Springer, Berlin, pp 217–262

    Google Scholar 

  69. Paulus W, Peiffer J (1989) Intratumoral histologic heterogeneity of gliomas. Cancer 64:442–447

    Article  PubMed  CAS  Google Scholar 

  70. Pierce MA, Johnson MD, Maciunas RJ, Murray MJ, Allen GS, Harbison MA, Creasy JL, Kessler RM (1995) Evaluating contrast-enhancing brain lesions in patients with AIDS using positron emission tomography. Ann Intern Med 123:594–598

    PubMed  CAS  Google Scholar 

  71. Riva P, Arista A, Franceschi G, Frattarelli M, Sturiale C, Riva N, Casi M, Rossitti R (1995) Local treatment of malignant gliomas by direct infusion of specific monoclonal antibodies labeled with 131I: comparison of the results obtained in recurrent and newly diagnosed brain tumors. Cancer Res 55 (23 Suppl): 5952S–5956S

    PubMed  CAS  Google Scholar 

  72. Rozental JM, Levine RL, Nickles RJ (1991) Changes in glucose uptake by malignant gliomas: preliminary study of prognostic significance. J Neuro-Oncol 10:75–83

    Article  CAS  Google Scholar 

  73. Rozental JM, Levine RL, Mehta MP, Kinsella TJ, Levin AB, Algan O, Mendoza M, Hanson JM, Schrader DA, Nickles RJ (1991) Early changes in brain tumor metabolism after treatment: the effects of stereotactic radiotherapy. Int J Radiat Oncol Biol Phys 20:1053–1060

    Article  PubMed  CAS  Google Scholar 

  74. Rozental JM, Cohen JD, Mehta MP, Levine RL, Hanson JM, Nickles RJ (1993) Acute changes in glucose uptake after treatment: the effects of carmustine (13CNU) on human glioblastoma multiforme. J Neuro-Oncol 15:57–66

    Article  CAS  Google Scholar 

  75. Ruiz A, Ganz WI, Post MJ, Camp A, Landy H, Mallin W, Sfakianakis GN (1994) Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients. AJNR 15:1885–1894

    PubMed  CAS  Google Scholar 

  76. Sasaki M, Ichija Y, Kuwabara Y, Otsuka M et al. (1990) Ringlike uptake of [18F]FDG in brain abscess: a PET study. J Comput Assist Tomogr 14:660–661

    Google Scholar 

  77. Shields AF, Grierson JR (1997) F-18-FLT can be used to image cell proliferation in vivo. J Nucl Med 38 (Suppl):249P

    Google Scholar 

  78. Schmidt D, Wunderlich G, Langen KJ et al. (1996) I-123-Methyl tyrosine (IMT) SPECT for evaluation of chemotherapy in cerebral gliomas. J Nucl Med 37 (Suppl): 354

    Google Scholar 

  79. Schober O, Meyer G-J, Duden C et al. (1987) Die Aufnahme von Aminosäuren in Hirntumoren mit der Positronenemissionstomographie als Indikator für die Beurteilung von Stoffwechselaktivität and Malignität. Fortschr Röntgenstr 147:503–509

    Article  CAS  Google Scholar 

  80. Tjuvjajev J, Macapinlac H, Daghighian F, Scott A, Ginos J, Finn R, Kothari P, Desai R, Zhang J, Beattie B, Graham M, Larson St, Blasberg R (1994) Imaging of brain tumor proliferative activity with Iodine-131-iododeoxyuridine. J Nucl Med 35:1407–1417

    Google Scholar 

  81. Tovi M, Lilja A, Bergstrom M, Ericsson A, Bergstrom K, Hartman M (1990) Delineation of gliomas with magnetic resonance imaging using Gd-DTPA in comparison with computed tomography and positron emission tomography. Acta Radiol 31:417–429

    PubMed  CAS  Google Scholar 

  82. Valk PE, Budinger TF, Levin VA, Silver P, Gutin PH, Doyle WK (1988) PET of malignant cerebral tumors after interstitial brachytherapy. J Neurosurg 69:830–838

    Article  PubMed  CAS  Google Scholar 

  83. Van der Borght T, Pauwels S, Lambotte L, Labar D, de Maeght S, Stroobandt G, La-terre C (1994) Brain tumor imaging with PET and 2-[carbon-11] thymidine. J Nucl Med 35:974–982

    Google Scholar 

  84. Vick NA, Ciric IS, Eller TW, Cozzens JW, Walsh A (1989) Reoperation for malignant astrocytoma. Neurology 39:430–432

    Article  PubMed  CAS  Google Scholar 

  85. Villringer K, Jager H, Dichgans M, Ziegler S, Poppinger J, Herz M, Kruschke C, Minoshima S, Pfister HW, Schwaiger M (1995) Differential diagnosis of CNS lesions in AIDS patients by FDG-PET. J Comput Assist Tomogr 19:532–536

    Article  PubMed  CAS  Google Scholar 

  86. Wester HJ, Herz M, Weber W, Heiss P, Senekowitsch-Schmidtke R, Schwaiger M, Stocklin G (1999) Synthesis and radiopharmacology of O-(2-[F18]fluoroethyl)-L-tyrosine for tumor imaging. J Nucl Med 40:205–212

    PubMed  CAS  Google Scholar 

  87. Woesler B, Kuwert T, Morgenroth C, Matheja P, Palkovic S, Schäfers M, Vollet B, Schäfers K, Lerch H, Brandau W, Samnick S, Wassmann H, Schober O (1997) Non-invasive grading of primary brain tumors: results of a comparative study between SPECT with 123I-methyl tyrosine and PET with 18F-deoxyglucose. Eur J Nucl Med 24:428–434

    PubMed  CAS  Google Scholar 

  88. Würker M, Herholz K, Voges J, Pietrzyk U, Treuer H, Bauer B, Sturm V, Heiss WD (1996) Glucose consumption and methionine uptake in low-grade gliomas after iodine-125 brachytherapy. Eur J Nucl Med 23:583–586

    Article  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kuwert, T., Delbeke, D. (2000). Brain tumors. In: Wieler, H.J., Coleman, R.E. (eds) PET in Clinical Oncology. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57703-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57703-1_11

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63329-4

  • Online ISBN: 978-3-642-57703-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics