Skip to main content
SpringerLink
Log in

Positron emission tomographic evaluation of radiochemotherapeutic effect on regional cerebral hemocirculation and metabolism in patients with gliomas

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Summary

Hemocirculatory and metabolic changes in tumor regions and the remote brain structure were analyzed using oxygen-15 and fluorine-18 positron emission tomography (PET) in eight patients with gliomas after radiation and chemotherapy of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) and N-(2-tetrahydrofuryl)-5-fluorouracil (FT 207).

In the tumor regions after the radiochemotherapy, regional cerebral blood flow (rCBF) and cerebral blood volume (rCBV) varied widely and there was a tendency for oxygen consumption (rCMRO2) to fall. The change in glucose consumption (rCMRGI) was especially noteworthy with regard to clinical correlations. Six patients with decreased rCMRGI values had 16010 to 29010 regressions in tumor size measured by X-ray computerized tomography (CT), and showed some period of clinical relief. In contrast, one patient with an increased rCMRGI value had some progression of tumor growth, and there were no clinical amelioration. The hemocirculation and metabolism of the contralateral gray matter seem to fluctuate by various factors as intracranial pressure and the effectiveness of the therapy.

In gliomas therapy, tumor rCMRGI values can be a good indicator of therapeutic effectiveness.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Di Chiro G, DeLaPaz RL, Brooks RA, Sakoloff L, Kornblith PL, Smith BH, Patronas NJ, Kufta CV, Kessler RM, Johnston GS, Manning RG, Wolf AP: Glucose utilization of cerebral gliomas measured by (18F)fluorodeoxyglucose and positron emission tomography. Neurology 32:1323–1329, 1982

    Google Scholar 

  2. Patronas NJ, Di Chiro G, Kufta C, Bairamian D, Kornblith PL, Simon R, Larson SM: Prediction of survival in glioma patients by means of positron emission tomography. J Neurosurg 62:816–822, 1985

    Google Scholar 

  3. Ito M, Lammertsma AA, Wise RJS, Bernardi S, Frackowiak RSJ, Heather JD, Mckenzie CG, Yhomas DGT, Jones T: Measurement of regional cerebral blood flow and oxygen utilization in patients with cerebral tumours using 15–0 and positron emission tomography: Analytical techniques and preliminary results. Neuroradiology 23:63–74, 1982

    Google Scholar 

  4. Tyler JL, Yamamoto YL, Diksic M, Theron J, Villemure JG, Worthington C, Evans AC, Feindel W: Pharmacokinetics of superselective intra-arterial and intravenous [11C]BCNU evaluated by PET. J Nucl Med 27:775–780, 1986

    Google Scholar 

  5. Kanno I, Miura S, Yamamoto S, Iida H, Murakami M, Takahashi K, Uemura K: Design and evaluation of a positron emission tomograph: HEADTOMEIII. J Comput Assist Tomogr 9:931–939, 1985

    Google Scholar 

  6. Frackowiak RSJ, Lenzi GL, Jones T, Heather JD: Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 150 and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr 4:727–736, 1980

    Google Scholar 

  7. Lammertsma AA, Jones T: Correction for the presence of in travascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 1. Description of the method. J Cereb Blood Flow Metabol 3:416–424, 1983

    Google Scholar 

  8. Yamaguchi T, Sasaki H, Ogawa T, Mineura K, Uemura K, Kanno I, Shishido F, Murakami M, Inugami A, Higano S: Relationship between tissue nature and [18F]fluorodeoxyglu-cose kinetics evaluated using dynamic positron emission tomography in human brain tumor. (in application for Symposium Neuroradiologicum Fellowship Award-1986).

  9. Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE: Tomographic measurement of local cerebral glucose metabolic rate in human with (F 18)2-fluoro-2-deoxy-D-glucose: Validation of method. Ann Neurol 2:371–388, 1979

    Google Scholar 

  10. Beaney RP: Positron emission tomography in the study of human tumors. Semin Nucl Med 14:324–341, 1984

    Google Scholar 

  11. DeLaPaz RL, Patronas NJ, Brooks RA, Smith BH, Kornblith PL, Milam H, Di Chiro G: Positron emission tomographic study of suppression of gray-matter glucose utilization by brain tumors. AJNR 4:826–829, 1983

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurosurgical Service, Akita University Hospital, Akita, Japan

    Katsuyoshi Mineura, Tsuneo Yasuda & Masayoshi Kowada

  2. Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels Akita, Akita, Japan

    Toshihide Ogawa, Fumio Shishido & Kazuo Uemura

Authors
  1. Katsuyoshi Mineura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tsuneo Yasuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masayoshi Kowada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Toshihide Ogawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Fumio Shishido
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kazuo Uemura
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mineura, K., Yasuda, T., Kowada, M. et al. Positron emission tomographic evaluation of radiochemotherapeutic effect on regional cerebral hemocirculation and metabolism in patients with gliomas. J Neuro-Oncol 5, 277–285 (1987). https://doi.org/10.1007/BF00151232

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00151232

Key words

Search

Navigation