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Perfusion Tracers: Biological Bases and Clinical Implications

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Nuclear Medicine in Psychiatry

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Abstract

Several radiopharmaceuticals are used in the clinical setting for brain imaging by the nuclear medicine modalities PET and SPECT. Among them, HMPAO and ECD are the most widely used, and it is usually assumed that they both reflect regional cerebral perfusion. Study of the biological basis of their cellular mechanisms at the basis of their brain retention highlighted that besides reflecting local flow, regional metabolic patterns may lead to the uncoupling perfusion signal with local retention of the tracer. Furthermore, it appears that very interesting similarities are emerging between astrocytes-neurons deoxyglucose/energy exchange and HMPAO/oxido-reduction equilibrium in normal state as well as in pathophysiological conditions.

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Author information

Authors and Affiliations

  1. Division of Nuclear Medicine, Geneva University Hospital, 1211, Geneva 14, Switzerland

    Daniel O. Slosman

  2. Institute of Physiology, 1005, Lausanne, Switzerland

    Luc Pellerin

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  1. Daniel O. Slosman
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  2. Luc Pellerin
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Editors and Affiliations

  1. Division of Nuclear Medicine, University Hospital Ghent, De Pintelaan 185, 9000, Gent, Belgium

    Andreas Otte  & Rudi A. Dierckx  & 

  2. University Department of Psychiatry, University Hospital Ghent, De Pintelaan 185, 9000, Gent, Belgium

    Kurt Audenaert  & Kees van Heeringen  & 

  3. Department of Medical Imaging Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium

    Kathelijne Peremans

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© 2004 Springer-Verlag Berlin Heidelberg

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Slosman, D.O., Pellerin, L. (2004). Perfusion Tracers: Biological Bases and Clinical Implications. In: Otte, A., Audenaert, K., Peremans, K., van Heeringen, K., Dierckx, R.A. (eds) Nuclear Medicine in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18773-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-18773-5_3

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