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11C-methionine uptake in cerebrovascular disease: A comparison with18F-FDG PET and99mTc-HMPAO SPECT

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Abstract

Objectives

Carbon-11-l-methyl-methionine (11C-methionine) has been reported to be useful for evaluating brain tumors, but several other brain disorders have also shown signs of high methionine uptake. We retrospectively evaluated the significance of11C-methionine uptake in cerebrovascular diseases, and also compared our results with those for18F-FDG PET and99mTc-HMPAO SPECT.

Methods

Seven patients, including 3 patients with a cerebral hematoma and 4 patients with a cerebral infarction, were examined. All 7 patients underwent both11C-methionine PET and99mTc-HMPAO SPECT, and 6 of them underwent18F-FDG PET.Results: A high11C-methionine uptake was observed in all 3 patients with cerebral hematoma. Increased99mTc-HMPAO uptake was observed in 2 out of 3 patients, and all 3 patients had decreased18F-FDG uptake. Of 4 patients with a cerebral infarction, high11C-methionine uptake was observed in 3. Increased99mTc-HMPAO uptake was also observed in one patient, whereas 3 patients had decreased18F-FDG uptake.

Conclusions

We should keep in mind that high11C-methionine uptake is frequently observed in cerebrovascular diseases. CVD should therefore be included in the differential diagnosis when encounting patients with a high11C-methionine uptake.

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Authors and Affiliations

  1. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan

    Makoto Nakagawa, Yasuo Kuwabara, Masayuki Sasaki, Hirofumi Koga, Tao Chen, Kouichirou Kaneko, Kazutaka Hayashi & Kouji Masuda

  2. Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan

    Takato Morioka

Authors
  1. Makoto Nakagawa
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  2. Yasuo Kuwabara
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  3. Masayuki Sasaki
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  4. Hirofumi Koga
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  5. Tao Chen
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  6. Kouichirou Kaneko
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  7. Kazutaka Hayashi
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  8. Takato Morioka
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  9. Kouji Masuda
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Correspondence to Makoto Nakagawa.

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Nakagawa, M., Kuwabara, Y., Sasaki, M. et al. 11C-methionine uptake in cerebrovascular disease: A comparison with18F-FDG PET and99mTc-HMPAO SPECT. Ann Nucl Med 16, 207–211 (2002). https://doi.org/10.1007/BF02996302

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  • DOI: https://doi.org/10.1007/BF02996302

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