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Acute Kidney Injury and Extracorporeal Blood Purification in Sepsis

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Management of Sepsis: The PIRO Approach

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Acute renal failure (ARF) occurs when the kidneys fail to eliminate nitrogenous waste products and to maintain homeostasis of water and electrolytes [1]. The consequences of this derangement can (if not reversed on time) precipitate a syndrome that can interfere with the already diffi cult management of intensive care unit (ICU) septic patients and worsen their prognosis.

Historically, many different defi nitions have been provided for ARF in different studies, which makes it diffi cult to compare experiences and explains the wide range of fi gures reported on incidence or mortality. The concept is still evolving, but recently some consensus has been reached that allows us to defi ne our understanding of ARF, or even better of acute kidney injury (AKI). The term “acute kidney injury” is a step forward that stresses the necessity to detect and provide support for this problem in the early stages of the process, before there is complete failure of the kidneys.

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Authors and Affiliations

  1. Department of Intensive Care Medicine, Santiago Apóstol Hospital, Vitoria, Spain

    Javier Maynar Moliner

  2. Department of Intensive Care Medicine, Doce de Octubre Hospital, C/Riaza 3, 2° D, Madrid, 28023, Spain

    José Ángel Sánchez-Izquierdo Riera

  3. Department of Intensive Care Medicine, Carlos Haya Hospital, Avda. Carlos Haya, s/n, Malaga, 29010, Spain

    Manuel Herrera Gutiérrez

  4. Department of Intensive Care Medicine, Santiago Apóstol Hospital, C/Olaguibel n° 29, Vitoria, 01104, Spain

    Amaia Quintano Rodero & Alberto Manzano Ramirez

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  1. Intensive Care Unit, Joan XXIII University Hospital, Carrer Mallafré Guasch, 4, Tarragona, 43007, Spain

    Jordi Rello MD, PhD , Emili Díaz MD, PhD  & Alejandro Rodríguez MD, PhD ,  & 

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Moliner, J.M., Riera, J.SI., Gutiérrez, M.H., Rodero, A.Q., Ramirez, A.M. (2009). Acute Kidney Injury and Extracorporeal Blood Purification in Sepsis. In: Rello, J., Díaz, E., Rodríguez, A. (eds) Management of Sepsis: The PIRO Approach. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00479-7_8

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