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Relapsing Polychondritis

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Rare Rheumatic Diseases of Immunologic Dysregulation

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Abstract

Relapsing polychondritis (RP) is a rare chronic autoimmune disease of unknown etiology. The disease is characterized by episodic inflammation of cartilaginous structures affecting hyaline, elastic and fibro cartilages. Proteoglycan-rich organs such as the eye, heart, blood vessels, and inner ear are also affected. It was first described in the literature in 1923 by Austrian physician Von jaksch-Wartenorst. Polychondropathia was the term initially used to describe this entity. Current nomenclature of relapsing polychondritis was proposed in 1960 by Pearson et al. RP is known to be associated with a number of rheumatologic conditions including vasculitis, rheumatoid arthritis, and systemic lupus erythematosus (SLE).

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References

  1. Pearson CM, Kline HM, Newcomer VD. Relapsing polychondritis. N Engl J Med. 1960;263:51–8. https://doi.org/10.1056/NEJM196007142630201.

    Article  CAS  PubMed  Google Scholar 

  2. Horvath A, Pall N, Molnar K, Kovats T, Surjan G, Vicsek T, et al. A nationwide study of the epidemiology of relapsing polychondritis. Clin Epidemiol. 2016;8:211–30. https://doi.org/10.2147/CLEP.S91439.clep-8-211. [pii].

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kent PD, Michet CJ Jr, Luthra HS. Relapsing polychondritis. Curr Opin Rheumatol. 2004;16(1):56–61.

    Article  Google Scholar 

  4. Dion J, Costedoat-Chalumeau N, Sene D, Cohen-Bittan J, Leroux G, Dion C, et al. Relapsing polychondritis can be characterized by three different clinical phenotypes: analysis of a recent series of 142 patients. Arthritis Rheumatol. 2016;68(12):2992–3001. https://doi.org/10.1002/art.39790.

    Article  PubMed  Google Scholar 

  5. Kong KO, Vasoo S, Tay NS, Chng HH. Relapsing polychondritis—an oriental case series. Singap Med J. 2003;44(4):197–200.

    CAS  Google Scholar 

  6. Ananthakrishna R, Goel R, Padhan P, Mathew J, Danda D. Relapsing polychondritis—case series from South India. Clin Rheumatol. 2009;28(Suppl 1):S7–10. https://doi.org/10.1007/s10067-008-1016-8.

    Article  PubMed  Google Scholar 

  7. Sharma A, Law AD, Bambery P, Sagar V, Wanchu A, Dhir V, et al. Relapsing polychondritis: clinical presentations, disease activity and outcomes. Orphanet J Rare Dis. 2014;9:198. https://doi.org/10.1186/s13023-014-0198-1. s13023-014-0198-1 [pii].

    Article  PubMed  PubMed Central  Google Scholar 

  8. Sharma A, Bambery P, Wanchu A, Sharma YP, Panda NK, Gupta A, et al. Relapsing polychondritis in North India: a report of 10 patients. Scand J Rheumatol. 2007;36(6):462–5. doi:788636960 [pii]. https://doi.org/10.1080/03009740701406502.

    Article  CAS  PubMed  Google Scholar 

  9. Lin DF, Yang WQ, Zhang PP, Lv Q, Jin O, Gu JR. Clinical and prognostic characteristics of 158 cases of relapsing polychondritis in China and review of the literature. Rheumatol Int. 2016;36(7):1003–9. https://doi.org/10.1007/s00296-016-3449-8. [pii].

    Article  CAS  PubMed  Google Scholar 

  10. McAdam LP, O'Hanlan MA, Bluestone R, Pearson CM. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore). 1976;55(3):193–215.

    Article  CAS  Google Scholar 

  11. Canas CA, Bonilla AF. Local cartilage trauma as a pathogenic factor in autoimmunity (one hypothesis based on patients with relapsing polychondritis triggered by cartilage trauma). Autoimmune Dis. 2012;2012:453698. https://doi.org/10.1155/2012/453698.

    Article  CAS  PubMed  Google Scholar 

  12. Berger R. Polychondritis resulting from intravenous substance abuse. Am J Med. 1988;85(3):415–7.

    Article  CAS  Google Scholar 

  13. Herrera I, Concha R, Molina EG, Schiff ER, Altman RD. Relapsing polychondritis, chronic hepatitis C virus infection, and mixed cryoglobulemia. Semin Arthritis Rheum. 2004;33(6):388–403. S0049017203002130 [pii].

    Article  Google Scholar 

  14. Terao C, Yoshifuji H, Yamano Y, Kojima H, Yurugi K, Miura Y, et al. Genotyping of relapsing polychondritis identified novel susceptibility HLA alleles and distinct genetic characteristics from other rheumatic diseases. Rheumatology (Oxford). 2016;55(9):1686–92. kew233 [pii]. https://doi.org/10.1093/rheumatology/kew233.

    Article  CAS  Google Scholar 

  15. Lang B, Rothenfusser A, Lanchbury JS, Rauh G, Breedveld FC, Urlacher A, et al. Susceptibility to relapsing polychondritis is associated with HLA-DR4. Arthritis Rheum. 1993;36(5):660–4.

    Article  CAS  Google Scholar 

  16. Zeuner M, Straub RH, Rauh G, Albert ED, Scholmerich J, Lang B. Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. J Rheumatol. 1997;24(1):96–101.

    CAS  PubMed  Google Scholar 

  17. Foidart JM, Abe S, Martin GR, Zizic TM, Barnett EV, Lawley TJ, et al. Antibodies to type II collagen in relapsing polychondritis. N Engl J Med. 1978;299(22):1203–7. https://doi.org/10.1056/NEJM197811302992202.

    Article  CAS  Google Scholar 

  18. Ebringer R, Rook G, Swana GT, Bottazzo GF, Doniach D. Autoantibodies to cartilage and type II collagen in relapsing polychondritis and other rheumatic diseases. Ann Rheum Dis. 1981;40(5):473–9.

    Article  CAS  Google Scholar 

  19. Hansson AS, Johannesson M, Svensson L, Nandakumar KS, Heinegard D, Holmdahl R. Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. Am J Pathol. 2004;164(3):959–66. S0002-9440(10)63183-5 [pii]. https://doi.org/10.1016/S0002-9440(10)63183-5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Hansson AS, Heinegard D, Piette JC, Burkhardt H, Holmdahl R. The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis. Arthritis Rheum. 2001;44(10):2402–12.

    Article  CAS  Google Scholar 

  21. Issing WJ, Selover D, Schulz P. Anti-labyrinthine antibodies in a patient with relapsing polychondritis. Eur Arch Otorhinolaryngol. 1999;256(4):163–6.

    Article  CAS  Google Scholar 

  22. Papo T, Piette JC, Le Thi HD, Godeau P, Meyer O, Kahn MF, et al. Antineutrophil cytoplasmic antibodies in polychondritis. Ann Rheum Dis. 1993;52(5):384–5.

    Article  CAS  Google Scholar 

  23. Ohwatari R, Fukuda S, Iwabuchi K, Inuyama Y, Onoe K, Nishihira J. Serum level of macrophage migration inhibitory factor as a useful parameter of clinical course in patients with Wegener's granulomatosis and relapsing polychondritis. Ann Otol Rhinol Laryngol. 2001;110(11):1035–40.

    Article  CAS  Google Scholar 

  24. Stabler T, Piette JC, Chevalier X, Marini-Portugal A, Kraus VB. Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. Arthritis Rheum. 2004;50(11):3663–7. https://doi.org/10.1002/art.20613.

    Article  CAS  PubMed  Google Scholar 

  25. Kumakiri K, Sakamoto T, Karahashi T, Mineta H, Takebayashi S. A case of relapsing polychondritis preceded by inner ear involvement. Auris Nasus Larynx. 2005;32(1):71–6. S0385-8146(04)00141-5 [pii]. https://doi.org/10.1016/j.anl.2004.09.012.

    Article  PubMed  Google Scholar 

  26. Ouchi N, Uzuki M, Kamataki A, Miura Y, Sawai T. Cartilage destruction is partly induced by the internal proteolytic enzymes and apoptotic phenomenon of chondrocytes in relapsing polychondritis. J Rheumatol. 2011;38(4):730–7. jrheum.101044 [pii]. https://doi.org/10.3899/jrheum.101044.

    Article  PubMed  Google Scholar 

  27. Damiani JM, Levine HL. Relapsing polychondritis—report of ten cases. Laryngoscope. 1979;89(6 Pt 1):929–46.

    CAS  PubMed  Google Scholar 

  28. Michet CJ Jr, McKenna CH, Luthra HS, O’Fallon WM. Relapsing polychondritis. Survival and predictive role of early disease manifestations. Ann Intern Med. 1986;104(1):74–8.

    Article  Google Scholar 

  29. Lee KS, Ernst A, Trentham DE, Lunn W, Feller-Kopman DJ, Boiselle PM. Relapsing polychondritis: prevalence of expiratory CT airway abnormalities. Radiology. 2006;240(2):565–73. 2401050562 [pii]. https://doi.org/10.1148/radiol.2401050562.

    Article  PubMed  Google Scholar 

  30. Boiselle PM, Feller-Kopman D, Ashiku S, Weeks D, Ernst A. Tracheobronchomalacia: evolving role of dynamic multislice helical CT. Radiol Clin N Am. 2003;41(3):627–36.

    Article  Google Scholar 

  31. Yamashita H, Takahashi H, Kubota K, Ueda Y, Ozaki T, Yorifuji H, et al. Utility of fluorodeoxyglucose positron emission tomography/computed tomography for early diagnosis and evaluation of disease activity of relapsing polychondritis: a case series and literature review. Rheumatology (Oxford). 2014;53(8):1482–90. keu147 [pii]. https://doi.org/10.1093/rheumatology/keu147.

    Article  Google Scholar 

  32. Arnaud L, Mathian A, Haroche J, Gorochov G, Amoura Z. Pathogenesis of relapsing polychondritis: a 2013 update. Autoimmun Rev. 2014;13(2):90–5. S1568-9972(13)00157-2 [pii]. https://doi.org/10.1016/j.autrev.2013.07.005.

    Article  CAS  Google Scholar 

  33. Arnaud L, Devilliers H, Peng SL, Mathian A, Costedoat-Chalumeau N, Buckner J, et al. The relapsing polychondritis disease activity index: development of a disease activity score for relapsing polychondritis. Autoimmun Rev. 2012;12(2):204–9. S1568-9972(12)00123-1 [pii]. https://doi.org/10.1016/j.autrev.2012.06.005.

    Article  PubMed  Google Scholar 

  34. Trentham DE, Le CH. Relapsing polychondritis. Ann Intern Med. 1998;129(2):114–22.

    Article  CAS  Google Scholar 

  35. Balsa A, Expinosa A, Cuesta M, MacLeod TI, Gijon-Banos J, Maddison PJ. Joint symptoms in relapsing polychondritis. Clin Exp Rheumatol. 1995;13(4):425–30.

    CAS  PubMed  Google Scholar 

  36. Papo T, Wechsler B, Bletry O, Piette AM, Godeau P, Piette JC. Pregnancy in relapsing polychondritis: twenty-five pregnancies in eleven patients. Arthritis Rheum. 1997;40(7):1245–9. doi: 10.1002/1529-0131(199707)40:7Spilt1245::AID-ART8Spigt3.0.CO;2-#.

    CAS  PubMed  Google Scholar 

  37. Bellamy N, Dewar CL. Relapsing polychondritis in pregnancy. J Rheumatol. 1990;17(11):1525–6.

    CAS  PubMed  Google Scholar 

  38. Carrion M, Giron JA, Ventura J, Camacho A, Garcia-Diez C. Airway complications in relapsing polychondritis. J Rheumatol. 1993;20(9):1628–9.

    CAS  PubMed  Google Scholar 

  39. Ernst A, Rafeq S, Boiselle P, Sung A, Reddy C, Michaud G, et al. Relapsing polychondritis and airway involvement. Chest. 2009;135(4):1024–30. S0012-3692(09)60256-7 [pii]. https://doi.org/10.1378/chest.08-1180.

    Article  PubMed  Google Scholar 

  40. Hong G, Kim H. Clinical characteristics and treatment outcomes of patients with relapsing polychondritis with airway involvement. Clin Rheumatol. 2013;32(9):1329–35. https://doi.org/10.1007/s10067-013-2279-2.

    Article  PubMed  Google Scholar 

  41. Krell WS, Staats BA, Hyatt RE. Pulmonary function in relapsing polychondritis. Am Rev Respir Dis. 1986;133(6):1120–3. https://doi.org/10.1164/arrd.1986.133.6.1120.

    Article  CAS  PubMed  Google Scholar 

  42. Sarodia BD, Dasgupta A, Mehta AC. Management of airway manifestations of relapsing polychondritis: case reports and review of literature. Chest. 1999;116(6):1669–75. S0012-3692(16)37012-X [pii].

    Article  CAS  Google Scholar 

  43. Suzuki M, Uchida K, Nagano M, Chijimatsu Y, Washizaki M, Inatomi K, et al. Case of relapsing polychondritis associated with persistent rib cartilage pain and severe tracheal stenosis—a review of 53 cases in Japan. Nihon Kyobu Shikkan Gakkai Zasshi. 1983;21(7):665–71.

    CAS  PubMed  Google Scholar 

  44. Lang-Lazdunski L, Hvass U, Paillole C, Pansard Y, Langlois J. Cardiac valve replacement in relapsing polychondritis. A review. J Heart Valve Dis. 1995;4(3):227–35.

    CAS  PubMed  Google Scholar 

  45. Dib C, Moustafa SE, Mookadam M, Zehr KJ, Michet CJ Jr, Mookadam F. Surgical treatment of the cardiac manifestations of relapsing polychondritis: overview of 33 patients identified through literature review and the Mayo Clinic records. Mayo Clin Proc. 2006;81(6):772–6. S0025-6196(11)61731-X [pii]. https://doi.org/10.4065/81.6.772.

    Article  PubMed  Google Scholar 

  46. Stone JR, Bruneval P, Angelini A, Bartoloni G, Basso C, Batoroeva L, et al. Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases. Cardiovasc Pathol. 2015;24(5):267–78. S1054-8807(15)00056-3 [pii]. https://doi.org/10.1016/j.carpath.2015.05.001.

    Article  PubMed  Google Scholar 

  47. Sharma A, Mittal T, Kumar S, Law AD, Wanchu A, Mahajan R, et al. Successful treatment of aortic root dilatation in a patient with relapsing polychondritis. Clin Rheumatol. 2013;32(Suppl 1):S59–61. https://doi.org/10.1007/s10067-010-1450-2.

    Article  PubMed  Google Scholar 

  48. Watanabe M, Suzuki H, Ara T, Nishizuka M, Morita M, Sato C, et al. Relapsing polychondritis complicated by giant cell myocarditis and myositis. Intern Med. 2013;52(12):1397–402. DN/JST.JSTAGE/internalmedicine/52.9080 [pii].

    Article  Google Scholar 

  49. Wu CM, Liu CP, Chiang HT, Lin SL. Cardiac manifestations of relapsing polychondritis—a case report. Angiology. 2004;55(5):583–6.

    Article  Google Scholar 

  50. Hojaili B, Keiser HD. Relapsing polychondritis presenting with complete heart block. J Clin Rheumatol. 2008;14(1):24–6. https://doi.org/10.1097/RHU.0b013e3181638173. 00124743-200802000-00006 [pii].

    Article  PubMed  Google Scholar 

  51. Yoo JH, Chodosh J, Dana R. Relapsing polychondritis: systemic and ocular manifestations, differential diagnosis, management, and prognosis. Semin Ophthalmol. 2011;26(4–5):261–9. https://doi.org/10.3109/08820538.2011.588653.

    Article  PubMed  Google Scholar 

  52. Sainz-de-la-Maza M, Molina N, Gonzalez-Gonzalez LA, Doctor PP, Tauber J, Foster CS. Scleritis associated with relapsing polychondritis. Br J Ophthalmol. 2016;100(9):1290–4. bjophthalmol-2015-306902 [pii]. https://doi.org/10.1136/bjophthalmol-2015-306902.

    Article  PubMed  Google Scholar 

  53. Chopra R, Chaudhary N, Kay J. Relapsing polychondritis. Rheum Dis Clin N Am. 2013;39(2):263–76. S0889-857X(13)00020-3 [pii]. https://doi.org/10.1016/j.rdc.2013.03.002.

    Article  Google Scholar 

  54. Frances C, el Rassi R, Laporte JL, Rybojad M, Papo T, Piette JC. Dermatologic manifestations of relapsing polychondritis. A study of 200 cases at a single center. Medicine (Baltimore). 2001;80(3):173–9.

    Article  CAS  Google Scholar 

  55. Ingen-Housz S, Venutolo E, Pinquier L, Cavelier-Balloy B, Dubertret L, Flageul B. Erythema annulare centrifugum and relapsing polychondritis. Ann Dermatol Venereol. 2000;127(8–9):735–9. MDOI-AD-08-2000-127-8-0151-9638-101019-ART11 [pii].

    CAS  PubMed  Google Scholar 

  56. Serra S, Monteiro P, Pires E, Vieira R, Telechea O, Ines L, et al. Relapsing polychondritis, interstitial granulomatous dermatitis and antiphospholipid syndrome: an unusual clinical association. Acta Reumatol Port. 2011;36(3):292–7.

    CAS  PubMed  Google Scholar 

  57. Rauh G, Kamilli I, Gresser U, Landthaler M. Relapsing polychondritis presenting as cutaneous polyarteritis nodosa. Clin Investig. 1993;71(4):305–9.

    Article  CAS  Google Scholar 

  58. Yaguchi H, Tsuzaka K, Niino M, Yabe I, Sasaki H. Aseptic meningitis with relapsing polychondritis mimicking bacterial meningitis. Intern Med. 2009;48(20):1841–4. JST.JSTAGE/internalmedicine/48.2173 [pii].

    Article  Google Scholar 

  59. Wang ZJ, Pu CQ, Zhang JT, Wang XQ, Yu SY, Shi Q, et al. Meningoencephalitis or meningitis in relapsing polychondritis: four case reports and a literature review. J Clin Neurosci. 2011;18(12):1608–15. S0967-5868(11)00301-8 [pii]. https://doi.org/10.1016/j.jocn.2011.04.012.

    Article  CAS  PubMed  Google Scholar 

  60. Stewart SS, Ashizawa T, Dudley AW Jr, Goldberg JW, Lidsky MD. Cerebral vasculitis in relapsing polychondritis. Neurology. 1988;38(1):150–2.

    Article  CAS  Google Scholar 

  61. Berg AM, Kasznica J, Hopkins P, Simms RW. Relapsing polychondritis and aseptic meningitis. J Rheumatol. 1996;23(3):567–9.

    CAS  PubMed  Google Scholar 

  62. Swen SJ, Leonards DJ, Swen WA, de Jonghe JF, Kalisvaarte KJ. Reversible cognitive decline in a patient with relapsing polychondritis. Tijdschr Gerontol Geriatr. 2009;40(5):203–7.

    Article  Google Scholar 

  63. Kashihara K, Kawada S, Takahashi Y. Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. J Neurol Sci. 2009;287(1–2):275–7. S0022-510X(09)00756-4 [pii]. https://doi.org/10.1016/j.jns.2009.08.004.

    Article  CAS  PubMed  Google Scholar 

  64. Hsu KC, Wu YR, Lyu RK, Tang LM. Aseptic meningitis and ischemic stroke in relapsing polychondritis. Clin Rheumatol. 2006;25(2):265–7. https://doi.org/10.1007/s10067-005-1152-3.

    Article  PubMed  Google Scholar 

  65. Bouton R, Capon A. Stroke as initial manifestation of relapsing polychondritis. Ital J Neurol Sci. 1994;15(1):61–3.

    Article  CAS  Google Scholar 

  66. Ohta Y, Nagano I, Niiya D, Fujioka H, Kishimoto T, Shoji M, et al. Nonparaneoplastic limbic encephalitis with relapsing polychondritis. J Neurol Sci. 2004;220(1–2):85–8. https://doi.org/10.1016/j.jns.2004.02.010. S0022510X04000413 [pii].

    Article  PubMed  Google Scholar 

  67. Massry GG, Chung SM, Selhorst JB. Optic neuropathy, headache, and diplopia with MRI suggestive of cerebral arteritis in relapsing polychondritis. J Neuroophthalmol. 1995;15(3):171–5.

    Article  CAS  Google Scholar 

  68. Fujioka S, Tsuboi Y, Mikasa M, Onozawa R, Saitoh N, Baba Y, et al. A case of encephalitis lethargica associated with relapsing polychondritis. Mov Disord. 2008;23(16):2421–3. https://doi.org/10.1002/mds.22345.

    Article  PubMed  Google Scholar 

  69. Brod S, Booss J. Idiopathic CSF pleocytosis in relapsing polychondritis. Neurology. 1988;38(2):322–3.

    Article  CAS  Google Scholar 

  70. Wasserfallen JB, Schaller MD. Unusual rhombencephalitis in relapsing polychondritis. Ann Rheum Dis. 1992;51(10):1184.

    Article  CAS  Google Scholar 

  71. Chang-Miller A, Okamura M, Torres VE, Michet CJ, Wagoner RD, Donadio JV Jr, et al. Renal involvement in relapsing polychondritis. Medicine (Baltimore). 1987;66(3):202–17.

    Article  CAS  Google Scholar 

  72. File I, Trinn C, Matyus Z, Ujhelyi L, Balla J, Matyus J. Relapsing polychondritis with p-ANCA associated vasculitis: Which triggers the other? World J Clin Cases. 2014;2(12):912–7. https://doi.org/10.12998/wjcc.v2.i12.912.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Firestein GS, Gruber HE, Weisman MH, Zvaifler NJ, Barber J, O'Duffy JD. Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome. Five patients with features of relapsing polychondritis and Behcet's disease. Am J Med. 1985;79(1):65–72. 0002-9343(85)90547-9 [pii].

    Article  CAS  Google Scholar 

  74. Van Besien K, Tricot G, Hoffman R. Relapsing polychondritis: a paraneoplastic syndrome associated with myelodysplastic syndromes. Am J Hematol. 1992;40(1):47–50.

    Article  Google Scholar 

  75. Tanaka K, Nakamura E, Naitoh K, Utsunomiya I, Matsuo K, Osabe S, et al. Relapsing polychondritis in a patient with myelodysplastic syndrome. Rinsho Ketsueki. 1990;31(11):1851–5.

    CAS  PubMed  Google Scholar 

  76. Yanagi T, Matsumura T, Kamekura R, Sasaki N, Hashino S. Relapsing polychondritis and malignant lymphoma: is polychondritis paraneoplastic? Arch Dermatol. 2007;143(1):89–90. 143/1/89 [pii]. https://doi.org/10.1001/archderm.143.1.89.

    Article  PubMed  Google Scholar 

  77. Azuma N, Nishioka A, Kuwana M, Sano H. Relapsing polychondritis coexisting with immune thrombocytopenic purpura: an unusual association. Rheumatology (Oxford). 2013;52(4):757–9. kes250 [pii]. https://doi.org/10.1093/rheumatology/kes250.

    Article  Google Scholar 

  78. Grasland A, Pouchot J, Teillet-Thiebaud F, Teillet F, Guillevin L, Vinceneux P. Relapsing polychondritis, thrombosis and antiphospholipid antibodies. Rev Med Interne. 1996;17(3):231–3. 0248866396812501 [pii].

    Article  CAS  Google Scholar 

  79. Sciascia S, Bazzan M, Baldovino S, Vaccarino A, Rossi D, Russo A, et al. Antiphospholipid syndrome and relapsing polychondritis: an unusual association. Lupus. 2011;20(12):1336–7. 0961203311409270 [pii]. https://doi.org/10.1177/0961203311409270.

    Article  CAS  PubMed  Google Scholar 

  80. Mark KA, Franks AG Jr. Colchicine and indomethacin for the treatment of relapsing polychondritis. J Am Acad Dermatol. 2002;46(2 Suppl Case Reports):S22–4. a105477 [pii].

    Article  Google Scholar 

  81. Park J, Gowin KM, Schumacher HR Jr. Steroid sparing effect of methotrexate in relapsing polychondritis. J Rheumatol. 1996;23(5):937–8.

    CAS  PubMed  Google Scholar 

  82. Kemta Lekpa F, Kraus VB, Chevalier X. Biologics in relapsing polychondritis: a literature review. Semin Arthritis Rheum. 2012;41(5):712–9. S0049-0172(11)00225-3 [pii]. https://doi.org/10.1016/j.semarthrit.2011.08.006.

    Article  PubMed  Google Scholar 

  83. Moulis G, Sailler L, Pugnet G, Astudillo L, Arlet P. Biologics in relapsing polychondritis: a case series. Clin Exp Rheumatol. 2013;31(6):937–9. 7121 [pii].

    PubMed  Google Scholar 

  84. Leroux G, Costedoat-Chalumeau N, Brihaye B, Cohen-Bittan J, Amoura Z, Haroche J, et al. Treatment of relapsing polychondritis with rituximab: a retrospective study of nine patients. Arthritis Rheum. 2009;61(5):577–82. https://doi.org/10.1002/art.24366.

    Article  PubMed  Google Scholar 

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  1. Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, Haryana, India

    M. B. Adarsh & Aman Sharma

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  1. Department of Medicine, Duke University School of Medicine, Durham, NC, USA

    Teresa Kathleen Tarrant

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Adarsh, M.B., Sharma, A. (2019). Relapsing Polychondritis. In: Tarrant, T. (eds) Rare Rheumatic Diseases of Immunologic Dysregulation. Rare Rheumatic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-99139-9_5

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