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Passagère cognitieve achteruitgang bij een patiënt met relapsing polychondritis

  • Klinische les
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Tijdschrift voor Gerontologie en Geriatrie

Samenvatting

Patiënt A, 58 jaar, wordt naar de geriatrie verwezen door de reumatoloog in verband met apathie. Anamnese vermeldt verspringende gewrichtspijnen, rode ontstoken ogen, apathie en interesseverlies. Lichamelijk onderzoek toont rode tranende ogen, bradyfrenie en bradykinesie. Bloedonderzoek laat verhoogde infectie parameters zien. De patiënt ontwikkeld koorts en bilateraal rode ontstoken oren. Diagnose van relapsing polychondritis wordt gesteld, de patiënt wordt behandeld met prednison en de symptomen verdwijnen.

Relapsing polychondritis is een chronische ziekte geassocieerd afbraak van structurele en functionele integriteit van kraakbeen en ontsteking van weefsel, rijk aan proteoglycanen. We diagnosticeerde relapsing polychondritis met een reversibele dementie, waarschijnlijk door een cerebrale vasculitis.

Reversible cognitive decline in a patient with relapsing polychondritis

Patient A, 58 years, is referred by the Rheumatologist to the Geriatrician concerning apathy. History reviews skipping arthritis, reddened and inflamed eyes, apathy and loss of interest. Physical examination revealed red tearing eyes, bradyphrenia and bradykinesia. Laboratory examination showed inflammation markers. The patient develops fever and bilateral reddened and inflamed ears. Diagnosis of relapsing polychondritis is made, the patient is treated with prednisone and the symptoms disappear.

Relapsing polychondritis is a chronical disease associated with inflammation and destruction of cartilaginous structures and proteoglycan rich structures.We diagnosed Relapsing Polychondritis with a reversible dementia,probably due to cerebral vasculitis.

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Literatuur

  1. Kent PD, Michet C, Luthra HS. Relapsing polychondritis. Current Opinion in Rheumatology 2003;16: 56-61

  2. Trendham DE, Le CH. Relapsing Polychondritis. Annals of Internal Medicine 1998;129:11-122

  3. Letko E, Zafirakis P, Baltatzis S, Voudouri A, Livir-Rallatos C, Foster CS. Relapsing Polychondritis: A Clinical Review. Seminars in Arthritis and Rheumatism, 2002; 31 (6): 384-395

    Google Scholar 

  4. Rapini RP, Warner NB. Relapsing Polychondritis. Clinics in Dermatology 2006;24: 482-485

  5. McAdam LP, O’Hanlan MA, Bluestone R, Pearson CM. Relapsing Polychondritis; prospective study of 23 patients an review of the literature. Medicine 1976; 55(3):193-215

    Google Scholar 

  6. Ota M, Mizukami K, Hayashi T, Sumita T, Asada T. Brain Magnetic Resonance Imaging and Single Photon Emission Computerized Tomography Findings In A Case Of Relasping Polychondritis Showing Cognitive Impairment And Personality Changes Progress in Neuro-Psychopharmacology and Biological Psychiatry 2005;29:347-349

  7. Hosford I, Glass J, Baker N. Relapsing Polychondritis- an unusual but potentially treatable cause of cognitive impairment. The New Zealand Medical Journal 2003; 116(1175):U463

    Google Scholar 

  8. Bradley DS, Das P, Griffiths MM, Luthra HS, David CS. HLA-DQ6/8 Double TRansgenic Mice Develop Auricular Chondritis Following Type II Collagen Immunization: A Model fro Human Relapsing Polychondritis Journal of Immunology 1998;161: 5046-5053

    Google Scholar 

  9. Michet CJ, McKenna CH, Luthra HS, O’Fallon WM. Relapsing Polychondritis Survival and Predictive Role of Early Disease Manifestations Annals of Internal Medicine 1986;104: 74-78

    Google Scholar 

  10. Dreher A, Aigner J, Fuchshuber S, Kastenbauer E. Relapsing Polychondritis: A Course over 20 Years with Cerebral Involvement Archive of Otolanryngoloy Headn And Neck Sugery 2000; 126:1495-1498

  11. S.S. Stewart Tetsuo Ashizawa, Dudley AW, Goldberg JW, Lidskey MD. Cerebral vascilaitis in relapsing Polychondritis Neurology 1988; 38:150-152

  12. Matzekies FG, Manger B, Schmitt-Haendle M, Nagel T, Kraetsch H-G, Kalden JR, Schulze-Koops H. Severe Septicaemia in a patient with Polychondritis and Sweet’s syndrome after initiation of treatment with infliximab Annals of Rheumatology Diseaeses 2003; 62: 81-82

    Google Scholar 

  13. Rosen O, Thiel A, Massenkeil G, Hiepe F, Haupl T, et al. Autologous Stem-cell Transplantation in Refractory Auto-immune Diseaeses after In Vivo Immunoablation And Ex Vivo Depletion of Mononucelar Cells Arthritis Research 2000, 2: 327-336

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    S. J. Swen

Authors
  1. S. J. Swen
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  2. D. J. H. Leonards
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  3. W. A. A. Swen
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  4. J. F. M. de Jonghe
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  5. K. J. Kalisvaart
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Correspondence to S. J. Swen.

Additional information

Klinisch geriater, Groene Hart Ziekenhuis, Gouda. Voorheen AIOS Geriatrie MCA Alkmaar Klinisch geriater, Ziekenhuis Walcheren Vlissingen. Voorheen AIOS Geriatrie MCA Alkmaar Reumatoloog, Medisch Centrum Alkmaar Neuropsycholoog, Medisch Centrum Alkmaar Klinisch geriater, Kennemergasthuis Haarlem Correspondentie: SJ Swen

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Swen, S.J., Leonards, D.J.H., Swen, W.A.A. et al. Passagère cognitieve achteruitgang bij een patiënt met relapsing polychondritis. GEEG 40, 203–207 (2009). https://doi.org/10.1007/BF03079589

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  • DOI: https://doi.org/10.1007/BF03079589

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