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MicroRNAs in Diabetes and Its Vascular Complications

  • Chapter
  • First Online:
Non-coding RNAs in the Vasculature

Part of the book series: Cardiac and Vascular Biology ((Abbreviated title: Card. vasc. biol.,volume 2))

  • 447 Accesses

Abstract

Diabetes is a complex, metabolic disorder that is characterised by chronic hyperglycaemia and is widely recognised as a major health threat worldwide. The major causes of morbidity and mortality in diabetes result from vascular complications. These can be both microvascular, resulting in retinopathy, nephropathy and neuropathy, and macrovascular, affecting the heart and peripheral vessels. In this chapter, the roles of microRNAs in the development of diabetes are described. In addition, we show how microRNA-mediated mechanisms in diabetes result in an impaired vascular reparative potential, acting via the bone marrow and both stem and progenitor cells. Finally, we discuss the roles of microRNAs in the development of specific microvascular and macrovascular complications in the context of diabetes, and describe the potential of microRNAs as circulating biomarkers of diabetic cardiovascular disease.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Health Sciences, University of Leicester, Leicester, UK

    Saran Shantikumar & Susana Rovira-Llopis

  2. University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain

    Susana Rovira-Llopis

  3. Laboratory of Cardiovascular Research, IRCCS MultiMedica, Milan, Italy

    Gaia Spinetti

  4. National Heart and Lung Institute, Imperial College London, London, UK

    Costanza Emanueli

  5. Bristol Heart Institute, University of Bristol, Upper Maudlin Street, Bristol, UK, BS2 8HW

    Costanza Emanueli

Authors
  1. Saran Shantikumar
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  2. Susana Rovira-Llopis
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  3. Gaia Spinetti
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  4. Costanza Emanueli
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Corresponding author

Correspondence to Costanza Emanueli .

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Editors and Affiliations

  1. Medizinische Hochschule Hannover, Institut für Molekulare und Translationale Therapiestrategien, Hannover, Germany

    Thomas Thum

  2. Institut für Kardiovaskuläre Regeneration, Universität Frankfurt, Zentrum für Molekulare Medizin, Frankfurt, Germany

    Stefanie Dimmeler

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Shantikumar, S., Rovira-Llopis, S., Spinetti, G., Emanueli, C. (2017). MicroRNAs in Diabetes and Its Vascular Complications. In: Thum, T., Dimmeler, S. (eds) Non-coding RNAs in the Vasculature. Cardiac and Vascular Biology, vol 2. Springer, Cham. https://doi.org/10.1007/978-3-319-52945-5_3

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