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Obese Subjects and Supplemental l-Arginine

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L-Arginine in Clinical Nutrition

Part of the book series: Nutrition and Health ((NH))

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Abstract

Obesity and overweight are constantly growing health problems throughout the world. According to the World Health Organization, nearly one billion adults are overweight, and 300 million people are obese (World Health Statistics. http://www.who.int/gho/publications/world_health_statistics/en/. Accessed 12 Apr 2014). Although it is widely accepted that obesity is associated with dyslipidemia, hypertension, atherosclerosis, stroke, insulin resistance, and some types of cancers, pharmacological treatment for this chronic disease is limited. The alarming increase in the occurrence of obesity and overweight has compelled researchers to seek new forms of drug therapy. Emerging evidence from both experimental and clinical studies shows that l-arginine (Arg) holds great promise for the prevention and treatment of adiposity and associated metabolic disorders in humans and animals. An anti-obesity effect of Arg is yet to be demonstrated, and the mechanisms responsible for the beneficial effects of Arg are very complex and involve nitric oxide (NO) signaling, enhancing of mitochondrial biogenesis, growth of brown adipose tissue and stimulation of thermogenesis, regulation of fat metabolic gene expression, and changes in fat tissue endocrine secretion.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Szamarzewskiego 84 Str., 60-569, Poznan, Poland

    Pawel Bogdanski MD, PhD & Matylda Kręgielska-Narożna MPH

  2. Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Wojska Polskiego 31, Poznan, Poland

    Joanna Suliburska Dr Pharm, PhD

  3. Department of Clinical Pharmacology, Poznan University of Medical Sciences, Szpitalna 27/33, Długa 1/2, Poznan, Poland

    Anna Jablecka

  4. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-569, Poznan, Poland

    Jarosław Walkowiak

Authors
  1. Pawel Bogdanski MD, PhD
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  2. Joanna Suliburska Dr Pharm, PhD
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  3. Matylda Kręgielska-Narożna MPH
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  4. Anna Jablecka
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  5. Jarosław Walkowiak
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Corresponding author

Correspondence to Pawel Bogdanski MD, PhD .

Editor information

Editors and Affiliations

  1. Faculty of Science & Technology Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department Nutrition and Dietetics Nutritional Sciences Division School of Biomedical & Health Sciences, King’s College London, London, United Kingdom

    Victor R. Preedy

  3. Nutritional Sciences Research Division Faculty of Life Science and Medicine, King’s College London, London, United Kingdom

    Rajkumar Rajendram

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Bogdanski, P., Suliburska, J., Kręgielska-Narożna, M., Jablecka, A., Walkowiak, J. (2017). Obese Subjects and Supplemental l-Arginine. In: Patel, V., Preedy, V., Rajendram, R. (eds) L-Arginine in Clinical Nutrition. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-26009-9_35

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  • DOI: https://doi.org/10.1007/978-3-319-26009-9_35

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-26007-5

  • Online ISBN: 978-3-319-26009-9

  • eBook Packages: MedicineMedicine (R0)

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