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Life Extension in Drosophila by Histone Deacetylase Inhibitors

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Life Extension

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 3))

Abstract

In the last years, epigenetic regulatory mechanisms are increasingly appreciated as central to a diverse array of age-associated processes such as cellular and organismal senescence, genomic instability, and tumorigenesis. Recently, histone deacetylase inhibitors (HDACIs), a novel class of drugs targeting epigenetic pathways, have been proposed as a highly promising type of drugs with anti-aging effects. This chapter presents an overview of the anti-aging and life-extending effects of HDACIs such as phenilbutyrate, sodium butyrate, trichistatin A and suberoylanilide hydroxamic acid as well as their plausible mechanism(s) of action in Drosophila melanogaster. Data supporting the hypothesis that life span extension induced by HDACIs may be caused by generalized changes in epigenetic regulation of gene expression are discussed. Overall, findings reviewed in this chapter suggest that uncovering which genetic factors and signaling pathways contributing to healthy aging can be influenced by HDACIs in fruit fly may facilitate the development of new strategies for treating and preventing age-related human diseases and health span extension.

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Acknowledgments

The authors would like to thank Oksana Zabuga for the assistance in preparing the manuscript. This work was supported by a joint grant of the Russian Foundation for Basic Research and the State Fund for Fundamental Research of Ukraine (project no. 11-04-90478-Ukr_f_a).

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Authors and Affiliations

  1. Laboratory of Epigenetics, Institute of Gerontology, Vyshgorodskaya St. 67, Kiev, 04114, Ukraine

    Alexander M. Vaiserman

  2. Laboratory of Genome Variation, Institute of Molecular Genetics of RAS, Kurchatov Sq. 2, Moscow, Russia

    Elena G. Pasyukova

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  1. Alexander M. Vaiserman
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  2. Elena G. Pasyukova
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Correspondence to Alexander M. Vaiserman .

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Editors and Affiliations

  1. Laboratory of Epigenetics, Institute of Gerontology, Kiev, Kievs'ka, Ukraine

    Alexander M. Vaiserman

  2. Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Komi Republic, Russia

    Alexey A. Moskalev

  3. Laboratory of Genome Variation, Institute of Molecular Genetics of RAS, Moscow, Russia

    Elena G. Pasyukova

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Vaiserman, A.M., Pasyukova, E.G. (2015). Life Extension in Drosophila by Histone Deacetylase Inhibitors. In: Vaiserman, A., Moskalev, A., Pasyukova, E. (eds) Life Extension. Healthy Ageing and Longevity, vol 3. Springer, Cham. https://doi.org/10.1007/978-3-319-18326-8_11

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