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The multidrug resistance phenotype: P-glycoprotein, regulation of the mdr genes and other related mechanisms

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Cell Growth and Oncogenesis

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Summary

In this article, molecular, genetic, structural and functional aspects related to P-glycoprotein will be reviewed, with a particular concern for the regulation of mdr gene expression. We will point out the role membrane cholesterol may play in the MDR phenotype, briefly review the current ways of modulating this phenotype and discuss present knowledge related to other non-Pgp proteins that can be linked to multiple drug resistance.

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  1. Institut de Biologie et Chimie des Protéines, UPR412 CNRS, 7, Passage du Vercors, F-69367, Lyon, Cedex 07, France

    L. G. Baggetto

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  1. Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany

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  2. Institute of Medical Biochemistry and Chemistry, University of Bari, Piazza G. Cesare, I-70124, Bari, Italy

    Darja Kanduc  & Sergio Papa  & 

  3. E.C. Slater Institute Faculty of Chemistry, University of Amsterdam, Plantage Muidergracht 12, NL-1018 TV, Amsterdam, The Netherlands

    J. M. Tager

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Baggetto, L.G. (1998). The multidrug resistance phenotype: P-glycoprotein, regulation of the mdr genes and other related mechanisms. In: Bannasch, P., Kanduc, D., Papa, S., Tager, J.M. (eds) Cell Growth and Oncogenesis. Molecular and Cell Biology Updates. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8950-6_20

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