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Formulation of Therapeutics for Neuraxial Infusion

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Neuraxial Therapeutics

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Abstract

Discussion or description of spinal delivery of therapeutics typically centers on the pharmacological agent to be administered both in terms of safety and efficacy. However, the pharmaceutical preparation of such agents for spinal delivery is equally important for appropriate biodistribution of the therapeutic and for safety. The unique properties of central nervous system tissue yield formulation requirements that are different from that of other parenteral routes of administration. In this chapter, we review the specific anatomical and physiological features of the central nervous system that drive formulation principles for neuraxial delivery and detail excipient properties that are considered appropriate for solutions intended for spinal drug delivery.

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Authors and Affiliations

  1. Departments of Pharmaceutics, Pharmacology, and Neuroscience, University of Minnesota Medical School, Minneapolis, MN, USA

    Carolyn A. Fairbanks

  2. Department of Neuroscience in the Medical School of the University of Minnesota, Minneapolis, MN, USA

    Cristina D. Peterson

  3. Department of Pharmaceutics, University of Minnesota Medical School, Minneapolis, MN, USA

    Benjamin Michael Clements

  4. MHealth Fairview Pharmacy Services, Adjunct Pharmaceutics Faculty, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA

    Virginia L. Ghafoor

  5. Departments of Anesthesiology and Pharmacology, University of California, San Diego, La Jolla, CA, USA

    Tony L. Yaksh

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  1. Carolyn A. Fairbanks
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  2. Cristina D. Peterson
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  3. Benjamin Michael Clements
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  4. Virginia L. Ghafoor
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  5. Tony L. Yaksh
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Correspondence to Carolyn A. Fairbanks .

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Editors and Affiliations

  1. (CTF-312), UC San Diego-Anesthesia Res Lab 081 (CTF-312), La Jolla, CA, USA

    Tony Yaksh

  2. University Hospital, Case Western Reserve University, Cleveland, OH, USA

    Salim Hayek

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Fairbanks, C.A., Peterson, C.D., Clements, B.M., Ghafoor, V.L., Yaksh, T.L. (2023). Formulation of Therapeutics for Neuraxial Infusion. In: Yaksh, T., Hayek, S. (eds) Neuraxial Therapeutics. Springer, Cham. https://doi.org/10.1007/978-3-031-39558-1_14

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