Abstract
Point-of-care ultrasound has become a critical diagnostic tool in the evaluation of dyspnea or shock to tease out the etiology and differential diagnosis, as well as a monitoring tool to guide further management including fluid resuscitation and de-resuscitation. With increasing recognition of neuro-monitoring in critically ill patients, more and more point-of-care applications of ultrasound are being explored in the evaluation and management of patients at risk for acute brain injury. A multitude of studies over the last few decades have explored the use of cranial ultrasound through B-mode ultrasonography, as well as Doppler indications for assessing cerebral hemodynamics, but the easy availability of computed tomography scans as well as angiography did not allow widespread use of ultrasound. With evolving complexities in critical care management involving advanced hemodynamic support and a focus on increasing access to health care in austere environments, an increasing need is being recognized to evaluate patients for intracerebral pathology when conventional modes of neuroimaging are not accessible. This chapter describes the use of cranial ultrasound B-mode ultrasonography for the evaluation of intracerebral pathology relevant to general intensive care.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Walter U. Transcranial sonography of the cerebral parenchyma: update on clinically relevant applications. Pers Med. 2012;1(1):334–43.
Caricato A, Pitoni S, Montini L, Bocci MG, Annetta P, Antonelli M. Echography in brain imaging in intensive care unit: state of the art. World J Radiol. 2014;6(9):636–42.
Robba C, Goffi A, Geeraerts T, Cardim D, Via G, Czosnyka M, et al. Brain ultrasonography: methodology, basic and advanced principles and clinical applications. A narrative review. Intensive Care Med. 2019;45(7):913–27.
Kaps MN, Erwin S, Tibo G, Ralf WB, Giovanni M, Guenter S, et al. Consensus recommendations for transcranial color-coded duplex sonography for the assessment of intracranial arteries in clinical trials on acute stroke. 2009.
Valaikiene J, Schlachetzki F, Azevedo E, Kaps M, Lochner P, Katsanos AH, et al. Point-of-care ultrasound in neurology - report of the EAN SPN/ESNCH/ERcNsono Neuro-POCUS Working Group. Ultraschall Med. 2022;43(4):354–66.
Millet A, Evain JN, Desrumaux A, Francony G, Bouzat P, Mortamet G. Clinical applications of transcranial Doppler in non-trauma critically ill children: a scoping review. Childs Nerv Syst. 2021;37(9):2759–68.
Lau VI, Arntfield RT. Point-of-care transcranial Doppler by intensivists. Crit Ultrasound J. 2017;9(1):21.
Robba C, Wong A, Poole D, Al Tayar A, Arntfield RT, Chew MS, et al. Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine. Intensive Care Med. 2021;47(12):1347–67.
Robba C, Poole D, Citerio G, Taccone FS, Rasulo FA. Brain ultrasonography consensus on skill recommendations and competence levels within the critical care setting. Neurocrit Care. 2020;32(2):502–11.
Marinoni M, Ginanneschi A, Forleo P, Amaducci L. Technical limits in transcranial Doppler recording: inadequate acoustic windows. Ultrasound Med Biol. 1997;23(8):1275–7.
Lin Y-P, Fu M-H, Tan T-Y. Factors associated with no or insufficient temporal bone window using transcranial color-coded sonography. J Med Ultrasound. 2015;23(3):129–32.
Kapoor S, Offnick A, Allen B, Brown PA, Sachs JR, Gurcan MN, et al. Brain topography on adult ultrasound images: techniques, interpretation, and image library. J Neuroimaging. 2022;32:1013.
Sarwal A, Elder NM. Point-of-care cranial ultrasound in a hemicraniectomy patient. Clin Pract Cases Emerg Med. 2018;2(4):375–7.
Becker G, Winkler J, Hofmann E, Bogdahn U. Differentiation between ischemic and hemorrhagic stroke by transcranial color-coded real-time sonography. J Neuroimaging. 1993;3(1):41–7.
Antipova D, Eadie L, Macaden AS, Wilson P. Diagnostic value of transcranial ultrasonography for selecting subjects with large vessel occlusion: a systematic review. Ultrasound J. 2019;11(1):29.
Mäurer M, Shambal S, Berg D, Woydt M, Hofmann E, Georgiadis D, et al. Differentiation between intracerebral hemorrhage and ischemic stroke by transcranial color-coded duplex-sonography. Stroke. 1998;29(12):2563–7.
Camps-Renom P, Méndez J, Granell E, Casoni F, Prats-Sánchez L, Martínez-Domeño A, et al. Transcranial duplex sonography predicts outcome following an intracerebral hemorrhage. AJNR Am J Neuroradiol. 2017;38(8):1543–9.
Lindner A, Gahn G, Becker G. Transcranial duplex sonography of hyperacute intracerebral hemorrhages. J Neuroimaging. 1997;7(3):199–202.
Masaeli M, Chahardoli M, Azizi S, Shekarchi B, Sabzghabaei F, Shekar Riz Fomani N, et al. Point of care ultrasound in detection of brain hemorrhage and skull fracture following pediatric head trauma; a diagnostic accuracy study. Arch Acad Emerg Med. 2019;7(1):e53.
Matsumoto N, Kimura K, Iguchi Y, Aoki J. Evaluation of cerebral hemorrhage volume using transcranial color-coded duplex sonography. J Neuroimaging. 2011;21(4):355–8.
Niesen WD, Schläger A, Reinhard M, Fuhrer H. Transcranial sonography to differentiate primary intracerebral hemorrhage from cerebral infarction with hemorrhagic transformation. J Neuroimaging. 2018;28(4):370–3.
Niesen WD, Schlaeger A, Bardutzky J, Fuhrer H. Correct outcome prognostication via sonographic volumetry in supratentorial intracerebral hemorrhage. Front Neurol. 2019;10:492.
Ovesen C, Christensen AF, Krieger DW, Rosenbaum S, Havsteen I, Christensen H. Time course of early postadmission hematoma expansion in spontaneous intracerebral hemorrhage. Stroke. 2014;45(4):994–9.
Wang HS, Kuo MF, Huang SC, Chou ML, Hung PC, Lin KL. Transcranial ultrasound diagnosis of intracranial lesions in children with headaches. Pediatr Neurol. 2002;26(1):43–6.
Woydt M, Greiner K, Perez J, Becker G, Krone A, Roosen K. Transcranial duplex-sonography in intracranial hemorrhage. Evaluation of transcranial duplex-sonography in the diagnosis of spontaneous and traumatic intracranial hemorrhage. Zentralbl Neurochir. 1996;57(3):129–35.
Kern R, Kablau M, Sallustio F, Fatar M, Stroick M, Hennerici MG, et al. Improved detection of intracerebral hemorrhage with transcranial ultrasound perfusion imaging. Cerebrovasc Dis (Basel, Switzerland). 2008;26(3):277–83.
Kukulska-Pawluczuk B, Książkiewicz B, Nowaczewska M. Imaging of spontaneous intracerebral hemorrhages by means of transcranial color-coded sonography. Eur J Radiol. 2012;81(6):1253–8.
Seidel G, Kaps M, Dorndorf W. Transcranial color-coded duplex sonography of intracerebral hematomas in adults. Stroke. 1993;24(10):1519–27.
Seidel G, Cangur H, Albers T, Meyer-Wiethe K. Transcranial sonographic monitoring of hemorrhagic transformation in patients with acute middle cerebral artery infarction. J Neuroimaging. 2005;15(4):326–30.
Seidel G, Cangür H, Albers T, Burgemeister A, Meyer-Wiethe K. Sonographic evaluation of hemorrhagic transformation and arterial recanalization in acute hemispheric ischemic stroke. Stroke. 2009;40(1):119–23.
Meyer-Wiethe K, Sallustio F, Kern R. Diagnosis of intracerebral hemorrhage with transcranial ultrasound. Cerebrovasc Dis (Basel, Switzerland). 2009;27(Suppl 2):40–7.
Seidel G, Kaps M, Gerriets T. Potential and limitations of transcranial color-coded sonography in stroke patients. Stroke. 1995;26(11):2061–6.
Tang SC, Huang SJ, Jeng JS, Yip PK. Third ventricle midline shift due to spontaneous supratentorial intracerebral hemorrhage evaluated by transcranial color-coded sonography. J Ultrasound Med. 2006;25(2):203–9.
Seidel G, Cangür H, Albers T, Burgemeister A, Meyer W. Sonographic evaluation of hemorrhagic transformation and arterial recanalization in acute hemispheric ischemic stroke. Stroke. 2009;40(1):119.
Seidel G, Cangür H, Albers T, Meyer W. Transcranial sonographic monitoring of hemorrhagic transformation in patients with acute middle cerebral artery infarction. J Neuroimaging. 2005;15(4):326.
Kummer RV, Broderick JP, Campbell BCV, Demchuk A, Goyal M, Hill MD, et al. The Heidelberg bleeding classification. Stroke. 2015;46(10):2981–6.
Becker G, Greiner K, Kaune B, Winkler J, Brawanski A, Warmuth-Metz M, et al. Diagnosis and monitoring of subarachnoid hemorrhage by transcranial color-coded real-time sonography. Neurosurgery. 1991;28(6):814–20.
Niesen WD, Rosenkranz M, Weiller C. Bedsided transcranial sonographic monitoring for expansion and progression of subdural hematoma compared to computed tomography. Front Neurol. 2018;9:374.
Niesen WD, Burkhardt D, Hoeltje J, Rosenkranz M, Weiller C, Sliwka U. Transcranial grey-scale sonography of subdural haematoma in adults. Ultraschall Med. 2006;27(3):251–5.
Becker G, Hofmann E, Woydt M, Hülsmann U, Maurer M, Lindner A, et al. Postoperative neuroimaging of high-grade gliomas: comparison of transcranial sonography, magnetic resonance imaging, and computed tomography. Neurosurgery. 1999;44(3):469–78.
Becker G, Krone A, Koulis D, Lindner A, Hofmann E, Roggendorf W, et al. Reliability of transcranial colour-coded real-time sonography in assessment of brain tumours: correlation of ultrasound, computed tomography and biopsy findings. Neuroradiology. 1994;36(8):585–90.
Becker G, Krone A, Schmitt K, Woydt M, Hofmann E, Lindner A, et al. Preoperative and postoperative follow-up in high-grade gliomas: comparison of transcranial color-coded real-time sonography and computed tomography findings. Ultrasound Med Biol. 1995;21(9):1123–35.
Meyer K, Seidel G, Knopp U. Transcranial sonography of brain tumors in the adult: an in vitro and in vivo study. J Neuroimaging. 2001;11(3):287–92.
Budisic M, Bosnjak J, Lovrencic-Huzjan A, Mikula I, Bedek D, Demarin V. Pineal gland cyst evaluated by transcranial sonography. Eur J Neurol. 2008;15(3):229–33.
Budisić M, Bosnjak J, Lovrencić-Huzjan A, Strineka M, Bene R, Azman D, et al. Transcranial sonography in the evaluation of pineal lesions: two-year follow up study. Acta Clin Croat. 2008;47(4):205–10.
Trevisi G, Barbone P, Treglia G, Mattoli MV, Mangiola A. Reliability of intraoperative ultrasound in detecting tumor residual after brain diffuse glioma surgery: a systematic review and meta-analysis. Neurosurg Rev. 2020;43(5):1221–33.
Alonso-Canovas A, Lopez-Sendon Moreno JL, Buisan J, Sainz de la Maza S, Costa-Frossard L, Garcia-Ribas G, et al. Does normal substantia nigra echogenicity make a difference in Parkinson’s disease diagnosis? A real clinical practice follow-up study. J Neurol. 2018;265(10):2363–9.
Bártová P, Kraft O, Bernátek J, Havel M, Ressner P, Langová K, et al. Transcranial sonography and (123)I-FP-CIT single photon emission computed tomography in movement disorders. Ultrasound Med Biol. 2014;40(10):2365–71.
Bor-Seng-Shu E, Pedroso JL, Felicio AC, Ciampi de Andrade D, Teixeira MJ, Braga-Neto P, et al. Substantia nigra echogenicity and imaging of striatal dopamine transporters in Parkinson’s disease: a cross-sectional study. Parkinsonism Relat Disord. 2014;20(5):477–81.
Doepp F, Plotkin M, Siegel L, Kivi A, Gruber D, Lobsien E, et al. Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson’s disease and essential tremor. Mov Disord. 2008;23(3):405–10.
Gaenslen A, Unmuth B, Godau J, Liepelt I, Di Santo A, Schweitzer KJ, et al. The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson’s disease: a prospective blinded study. Lancet Neurol. 2008;7(5):417–24.
Hagenah JM, König IR, Becker B, Hilker R, Kasten M, Hedrich K, et al. Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles. J Neurol. 2007;254(10):1407–13.
Hellwig S, Reinhard M, Amtage F, Guschlbauer B, Buchert R, Tüscher O, et al. Transcranial sonography and [18F]fluorodeoxyglucose positron emission tomography for the differential diagnosis of parkinsonism: a head-to-head comparison. Eur J Neurol. 2014;21(6):860–6.
Li DH, Zhang LY, Hu YY, Jiang XF, Zhou HY, Yang Q, et al. Transcranial sonography of the substantia nigra and its correlation with DAT-SPECT in the diagnosis of Parkinson’s disease. Parkinsonism Relat Disord. 2015;21(8):923–8.
Lobsien E, Schreiner S, Plotkin M, Kupsch A, Schreiber SJ, Doepp F. No correlation of substantia nigra echogenicity and nigrostriatal degradation in Parkinson’s disease. Mov Disord. 2012;27(3):450–3.
Mašková J, Školoudík D, Burgetová A, Fiala O, Brůha R, Záhoráková D, et al. Comparison of transcranial sonography-magnetic resonance fusion imaging in Wilson’s and early-onset Parkinson’s diseases. Parkinsonism Relat Disord. 2016;28:87–93.
Schweitzer KJ, Hilker R, Walter U, Berg D. Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson’s disease. Mov Disord. 2006;21(1):94–8.
Spiegel J, Hellwig D, Möllers MO, Behnke S, Jost W, Fassbender K, et al. Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson’s disease. Brain. 2006;129(Pt 5):1188–93.
Sprenger FS, Wurster I, Seppi K, Stockner H, Scherfler C, Sojer M, et al. Substantia nigra hyperechogenicity and Parkinson’s disease risk in patients with essential tremor. Mov Disord. 2016;31(4):579–83.
Vlaar AM, de Nijs T, van Kroonenburgh MJ, Mess WH, Winogrodzka A, Tromp SC, et al. The predictive value of transcranial duplex sonography for the clinical diagnosis in undiagnosed parkinsonian syndromes: comparison with SPECT scans. BMC Neurol. 2008;8:42.
Weise D, Lorenz R, Schliesser M, Schirbel A, Reiners K, Classen J. Substantia nigra echogenicity: a structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson’s disease. Mov Disord. 2009;24(11):1669–75.
Seidel G, Gerriets T, Kaps M, Missler U. Dislocation of the third ventricle due to space-occupying stroke evaluated by transcranial duplex sonography. J Neuroimaging. 1996;6(4):227–30.
Gerriets T, Stolz E, König S, Babacan S, Fiss I, Jauss M, et al. Sonographic monitoring of midline shift in space-occupying stroke. Stroke. 2001;32(2):442–7.
Motuel J, Biette I, Srairi M, Mrozek S, Kurrek MM, Chaynes P, et al. Assessment of brain midline shift using sonography in neurosurgical ICU patients. Crit Care. 2014;18(6):676.
Siepen BM, Grubwinkler S, Wagner A, Gruber C, Dickopf A, Linker RA, et al. Neuromonitoring using neurosonography and pupillometry in a weaning and early neurorehabilitation unit. J Neuroimaging. 2020;30(5):631–9.
Stolz E, Gerriets T, Fiss I, Babacan SS, Seidel G, Kaps M. Comparison of transcranial color-coded duplex sonography and cranial CT measurements for determining third ventricle midline shift in space-occupying stroke. AJNR Am J Neuroradiol. 1999;20(8):1567–71.
Llompart Pou JA, Abadal Centellas JM, Palmer Sans M, Pérez Bárcena J, Casares Vivas M, Homar Ramírez J, et al. Monitoring midline shift by transcranial color-coded sonography in traumatic brain injury. A comparison with cranial computerized tomography. Intensive Care Med. 2004;30(8):1672–5.
Bertram M, Khoja W, Ringleb P, Schwab S. Transcranial colour-coded sonography for the bedside evaluation of mass effect after stroke. Eur J Neurol. 2000;7(6):639–46.
Kiphuth IC, Huttner HB, Struffert T, Schwab S, Köhrmann M. Sonographic monitoring of ventricle enlargement in posthemorrhagic hydrocephalus. Neurology. 2011;76(10):858–62.
Harrer JU, Tsivgoulis G. Transcranial sonography for monitoring hydrocephalus: an underestimated imaging modality. Neurology. 2011;76(10):852–3.
Müller M, Esser R, Kötter K, Voss J, Müller A, Stellmes P. Width of 3. Ventricle: reference values and clinical relevance in a cohort of patients with relapsing remitting multiple sclerosis. Open Neurol J. 2013;7:11–6.
Caricato A, Ioannoni E, Gelormini C. Is it really third ventricle? A pitfall in the diagnosis of hydrocephalus by brain ultrasound. Neurocrit Care. 2020;33(3):844–6.
Robba C, Simonassi F, Ball L, Pelosi P. Transcranial color-coded duplex sonography for bedside monitoring of central nervous system infection as a consequence of decompressive craniectomy after traumatic brain injury. Intensive Care Med. 2019;45(8):1143–4.
Niesen WD, Reinhard M, Gierthmuehlen M, Fuhrer H. Sonographic-assisted catheter-positioning in intracerebral hemorrhage. Front Neurol. 2018;9:651.
Srinivasan V, Smith M, Bonomo J. Bedside cranial ultrasonography in patients with hemicraniectomies: a novel window into pathology. Neurocrit Care. 2019;31(2):432–3.
Caricato A, Mignani V, Bocci MG, Pennisi MA, Sandroni C, Tersali A, et al. Usefulness of transcranial echography in patients with decompressive craniectomy: a comparison with computed tomography scan. Crit Care Med. 2012;40(6):1745–52.
Bendella H, Maegele M, Hartmann A, Spreer J, Rommel N, Lefering R, et al. Cerebral ventricular dimensions after decompressive craniectomy: a comparison between bedside sonographic duplex technique and cranial computed tomography. Neurocrit Care. 2017;26(3):321–9.
Ivanov M, Wilkins S, Poeata I, Brodbelt A. Intraoperative ultrasound in neurosurgery - a practical guide. Br J Neurosurg. 2010;24(5):510–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Sarwal, A. (2023). Cranial Ultrasound for Intracerebral Pathology. In: Robba, C., Messina, A., Wong, A., Vieillard-Baron, A. (eds) Basic Ultrasound Skills “Head to Toe” for General Intensivists. Lessons from the ICU. Springer, Cham. https://doi.org/10.1007/978-3-031-32462-8_18
Download citation
DOI: https://doi.org/10.1007/978-3-031-32462-8_18
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-32461-1
Online ISBN: 978-3-031-32462-8
eBook Packages: MedicineMedicine (R0)