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Mesenchymal Stem Cells for Regeneration of the Ocular Surface

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Modern Keratoplasty

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Mesenchymal tissues can provide a source of stem cells (MSCs) that are readily available, non-immunogenic, and have tremendous regenerative and anti-inflammatory properties. For these reasons, MSCs have emerged as very attractive candidates for cell-based therapies in numerous and diverse clinical applications including the treatment of ocular surface diseases such as limbal stem cell deficiency, dry eye disease, or even as a potential therapy to improve corneal allograft survival. Although some of the current preclinical evidence has already been successfully translated into clinical applications, work must continue to overcome all of the scientific and technical challenges that remain unsolved. This book chapter summarizes the main preclinical and clinical evidence that strongly supports MSC-based therapies as safe and effective treatments for the regeneration of the ocular surface.

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Abbreviations

CD:

Cluster of differentiation

CK:

Cytokeratin

CLET:

Cultivated limbal epithelial transplantation

DED:

Dry eye disease

EVs:

Extracellular vesicles

GVHD:

Graft-versus-host disease

HLA-DR:

Human leukocyte antigen-DR

IL:

Interleukin

LESCs:

Limbal epithelial stem cells

LSCD:

Limbal stem cell deficiency

MSCs:

Mesenchymal stem cells

oGVHD:

Ocular graft-versus-host disease

TNF-α:

Tumour necrosis factor alpha

Treg:

Regulatory T cells

TSG-6:

Tumour necrosis factor-stimulated gene/protein-6

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Acknowledgements

We thank B. Bromberg (Certified Editor in Life Sciences, Xenofile Editing) for his assistance in the final editing and preparation of this manuscript. This work was funded by the Ministry of Science and Innovation (grant PID2019-105525RB-100/AEI/10.13039/501100011033 MICINN/FEDER, EU), Spain; the Carlos III National Institute of Health, CIBER-BBN (CB06/01/003 MICINN/FEDER, EU), Spain; and the Regional Center for Regenerative Medicine and Cell Therapy of Castilla y León, Spain.

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Author notes

  1. Marina López-Paniagua, Sara Galindo, Ana de la Mata and Teresa Nieto-Miguel contributed equally.

Authors and Affiliations

  1. IOBA (Institute of Applied Ophthalmobiology), University of Valladolid, Valladolid, Spain

    Marina López-Paniagua, Sara Galindo, Margarita Calonge, Inmaculada Pérez, José M. Herreras, Ana de la Mata & Teresa Nieto-Miguel

  2. CIBER-BBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine), Carlos III National Institute of Health, Madrid, Spain

    Marina López-Paniagua, Sara Galindo, Margarita Calonge, José M. Herreras, Ana de la Mata & Teresa Nieto-Miguel

  3. Castile and Leon Networking Center for Regenerative Medicine and Cell Therapy, Valladolid, Spain

    Marina López-Paniagua, Sara Galindo, Margarita Calonge, Inmaculada Pérez, José M. Herreras, Ana de la Mata & Teresa Nieto-Miguel

  4. Department of Nursing. Faculty of Nursing, University of Valladolid, Valladolid, Spain

    Inmaculada Pérez

  5. University Clinic Hospital, Valladolid, Spain

    José M. Herreras

  6. Department of Cell Biology, Genetics, Histology and Pharmacology, University of Valladolid, Valladolid, Spain

    Teresa Nieto-Miguel

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  1. Marina López-Paniagua
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Correspondence to Teresa Nieto-Miguel .

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  1. Vissum Miranza, Miguel Hernández University, Alicante, Spain

    Jorge L. Alió

  2. Vissum-Instituto Oftalmologico de Alica, Miguel Hernandez University, Alicante, Alicante, Spain

    Jorge L. Alió del Barrio

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López-Paniagua, M. et al. (2023). Mesenchymal Stem Cells for Regeneration of the Ocular Surface. In: Alió, J.L., del Barrio, J.L.A. (eds) Modern Keratoplasty. Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-031-32408-6_15

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