Skip to main content

Management of High-Grade Spondylolisthesis Including Reduction Techniques

  • Chapter
  • First Online:
Spondylolisthesis

Abstract

There exists significant controversy in the literature regarding the surgical treatment of high-grade spondylolisthesis: in situ fusion versus reduction, the timing of surgery, and the techniques for achieving fixation are highly varied. High-grade spondylolisthesis is a complicated, three-dimensional deformity with complex pathomechanics and secondary anatomic changes that develop over time. While the classification schemes and management modalities of high-grade spondylolisthesis continue to evolve with our understanding of these deformities, there is general agreement that surgical treatment of high-grade, unbalanced spondylolisthesis is the management of choice. While reduction and fixation of these high-grade slips are historically fraught with complications, including nerve injury and loss of fixation, in situ fusion is also not without reportedly severe complications. However, in the authors’ varied, multi-year experience, anatomic reduction with interbody fusion and posterior instrumentation has yielded excellent results with a relatively low complication rate.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mac-Thiong JM, Labelle H. Based on current literature, a proposal for a surgical classification of pediatric lumbosacral spondylolisthesis. Eur Spine J. 2006;15(10):1425–35.

    Article  PubMed  Google Scholar 

  2. Mac-Thiong JM, Wang Z, de Guise JA, Labelle H. Postural model of sagittal spino-pelvic alignment and its relevance for lumbosacral developmental spondylolisthesis. Spine (Phila Pa 1976). 2008;33(21):2316–25.

    Article  PubMed  Google Scholar 

  3. Shufflebarger HL. High dysplastic spondylolisthesis: anatomic reduction. The Harms/Shufflebarger technique. In: DeWald RL, Bridwell KH, editors. The textbook of spinal surgery. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2011. p. 660–7.

    Google Scholar 

  4. Wang W, Aubin CE, Cahill P, Baran G, Arnoux PJ, Parent S, Labelle H. Biomechanics of high-grade spondylolisthesis with and without reduction. Med Biol Eng Comput. 2016;54(4):619–28.

    Article  PubMed  Google Scholar 

  5. Labelle HRP, Berthonnaud E, Mac-Thiong JM, Hresko T, Dimar, J, Parent S, Weidenbaum M, Brown C, Hu S. Spondylolisthesis classification based on spino-pelvic alignment. In: Podium presentation at the 2009 Scoliosis Research Society annual meeting. San Antonio, USA; 2009.

    Google Scholar 

  6. Hresko MT, Labelle H, Roussouly P, Berthonnaud E. Classification of high-grade spondylolistheses based on pelvic version and spine balance: possible rationale for reduction. Spine (Phila Pa 1976). 2007;32(20):2208–13.

    Article  PubMed  Google Scholar 

  7. Labelle H, Mac-Thiong JM, Roussouly P. Spino-pelvic sagittal balance of spondylolisthesis: a review and classification. Eur Spine J. 2011;20(Suppl 5):641–6.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Sebaaly A, El Rachkidi R, Grobost P, Burnier M, Labelle H, Roussouly P. L5 incidence: an important parameter for spinopelvic balance evaluation in high-grade spondylolisthesis. Spine J. 2018;18(8):1417–23.

    Article  PubMed  Google Scholar 

  9. Kunze KN, Lilly DT, Khan JM, Louie PK, Ferguson J, Basques BA, Nolte MT, Dewald CJ. High-grade spondylolisthesis in adults: current concepts in evaluation and management. Int J Spine Surg. 2020;14(3):327–40.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Vialle R, Benoist M. High-grade lumbosacral spondylolisthesis in children and adolescents: pathogenesis, morphological analysis, and therapeutic strategy. Jt Bone Spine. 2007;74(5):414–7.

    Article  Google Scholar 

  11. Passias PG, Poorman CE, Yang S, Boniello AJ, Jalai CM, Worley N, Lafage V. Surgical treatment strategies for high-grade spondylolisthesis: a systematic review. Int J Spine Surg. 2015;9:50.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Koller H, Mühlenkamp K, Hitzl W, Koller J, Ferraris L, Hostettler IC, Hempfing A. Surgical outcomes with anatomic reduction of high-grade spondylolisthesis revisited: an analysis of 101 patients. J Neurosurg Spine. 2021;17:1–11.

    Article  Google Scholar 

  13. Martiniani MLC, Specchia N. “In situ” fusion or reduction in high-grade dysplastic developmental spondylolisthesis. Eur Spine J. 2012;21(Suppl 1):S134–40.

    Article  PubMed  Google Scholar 

  14. Lian XF, Hou TS, Xu JG, et al. Single segment of posterior lumbar interbody fusion for adult isthmic spondylolisthesis: reduction or fusion in situ. Eur Spine J. 2014;23(1):172–9.

    Article  PubMed  Google Scholar 

  15. Lak AM, Abunimer AM, Devi S, Chawla S, Aydin L, Tafel I, Smith TR, Mekary RA, Zaidi HA. Reduction versus in situ fusion for adult high-grade spondylolisthesis: a systematic review and meta-analysis. World Neurosurg. 2020;138:512–20.

    Article  PubMed  Google Scholar 

  16. DeWald RL, Faut MM, Taddonio RF, Neuwirth MG. Severe lumbosacral spondylolisthesis in adolescents and children. Reduction and staged circumferential fusion. J Bone Jt Surg Am. 1981;63(4):619–26.

    Article  CAS  Google Scholar 

  17. Johnson JR, Kirwan EO. The long-term results of fusion in situ for severe spondylolisthesis. J Bone Jt Surg Br. 1983;65(1):43–6.

    Article  CAS  Google Scholar 

  18. Poussa M, Schlenzka D, Seitsalo S, Ylikoski M, Hurri H, Osterman K. Surgical treatment of severe isthmic spondylolisthesis in adolescents. Reduction or fusion in situ. Spine (Phila Pa 1976). 1993;18(7):894–901.

    Article  CAS  PubMed  Google Scholar 

  19. Akamaru T, Kawahara N, Yoon ST, et al. Adjacent segment motion after a simulated lumbar fusion in different sagittal alignments: a biomechanical analysis. Spine (Phila Pa 1976). 2003;28(14):1560–6.

    Article  PubMed  Google Scholar 

  20. Schoenecker PL, Cole HO, Herring JA, Capelli AM, Bradford DS. Cauda equina syndrome after in situ arthrodesis for severe spondylolisthesis at the lumbosacral junction. J Bone Jt Surg Am. 1990;72(3):369–77.

    Article  CAS  Google Scholar 

  21. Grzegorzewski A, Kumar SJ. In situ posterolateral spine arthrodesis for grades III, IV, and V spondylolisthesis in children and adolescents. J Pediatr Orthop. 2000;20(4):506–11.

    Article  CAS  PubMed  Google Scholar 

  22. Molinari RW, Bridwell KH, Lenke LG, Ungacta FF, Riew KD. Complications in the surgical treatment of pediatric high-grade, isthmic dysplastic spondylolisthesis. A comparison of three surgical approaches. Spine (Phila Pa 1976). 1999;24(16):1701–11.

    Article  CAS  PubMed  Google Scholar 

  23. Poussa M, Remes V, Lamberg T, et al. Treatment of severe spondylolisthesis in adolescence with reduction or fusion in situ: long-term clinical, radiologic, and functional outcome. Spine (Phila Pa 1976). 2006;31(5):583–90.

    Article  PubMed  Google Scholar 

  24. Hanley EN Jr, Levy JA. Surgical treatment of isthmic lumbosacral spondylolisthesis. Analysis of variables influencing results. Spine (Phila Pa 1976). 1989;14(1):48–50.

    Article  PubMed  Google Scholar 

  25. Dhall SS, Wang MY, Mummaneni PV. Clinical and radiographic comparison of mini-open transforaminal lumbar interbody fusion with open transforaminal lumbar interbody fusion in 42 patients with long-term follow-up. J Neurosurg Spine. 2008;9(6):560–5.

    Article  PubMed  Google Scholar 

  26. Holly LT, Schwender JD, Rouben DP, Foley KT. Minimally invasive transforaminal lumbar interbody fusion: indications, technique, and complications. Neurosurg Focus. 2006;20(3):E6.

    Article  PubMed  Google Scholar 

  27. Logroscino CA, Proietti L, Pola E, Scaramuzzo L, Tamburrelli FC. A minimally invasive posterior lumbar interbody fusion for degenerative lumbar spine instabilities. Eur Spine J. 2011;20(Suppl 1):S41–5.

    Article  PubMed  Google Scholar 

  28. Kleihues H, Albrecht S, Noack W. Topographic relations between the neural and ligamentous structures of the lumbosacral junction: in-vitro investigation. Eur Spine J. 2001;10(2):124–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Lamartina C, Zavatsky JM, Petruzzi M, Specchia N. Novel concepts in the evaluation and treatment of high-dysplastic spondylolisthesis. Eur Spine J. 2009;18(Suppl 1):133–42.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Chung JY, Parthasarathy S, Avadhani A, Rajasekaran S. Reduction of high grade listhesis. Eur Spine J. 2010;19(2):353–4.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Rengachary SS, Balabhandra R. Reduction of spondylolisthesis. Neurosurg Focus. 2002;13(1):E2.

    Article  PubMed  Google Scholar 

  32. Bradford DS. Treatment of severe spondylolisthesis: a combined approach for reduction and stabilization. Spine (Phila Pa 1976). 1979;4(5):423–9.

    Article  CAS  PubMed  Google Scholar 

  33. Harrington PR, Tullos HS. Spondylolisthesis in children. Observations and surgical treatment. Clin Orthop Relat Res. 1971;79:75–84.

    Article  CAS  PubMed  Google Scholar 

  34. Karampalis CGM, Shafafy M, Webb J. High-grade spondylolisthesis: gradual reduction using Magerl’s external fixator followed by circumferential fusion technique and long-term results. Eur Spine J. 2012;21(Suppl 2):S200–6.

    Article  PubMed  Google Scholar 

  35. Curcin A, Edwards CC. Reduction and fusion of spondyloptosis: long-term follow-up. In: Presented at the Scoliosis Research Society annual meeting; September 21–24. Portland; 1994.

    Google Scholar 

  36. Schwender JD, Holly LT, Rouben DP, Foley KT. Minimally invasive transforaminal lumbar interbody fusion (TLIF): technical feasibility and initial results. J Spinal Disord Tech. 2005;18(Suppl):S1–6.

    Article  PubMed  Google Scholar 

  37. Rampersaud YR, Gurgo RD. Mini-open posterior lumbar interbody fusion for deformity. In: Mummaneni PV, Lenke L, Haid R, editors. Spinal deformity: a guide to surgical planning and management. St. Louis: Quality Medical Publishing; 2008. p. 721–48.

    Google Scholar 

  38. Quraishi NA, Rampersaud YR. Minimal access bilateral transforaminal lumbar interbody fusion for high-grade isthmic spondylolisthesis. Eur Spine J. 2013;22(8):1707–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Boos N, Marchesi D, Zuber K, Aebi M. Treatment of severe spondylolisthesis by reduction and pedicular fixation. A 4–6-year follow-up study. Spine (Phila Pa 1976). 1993;18(12):1655–61.

    Article  CAS  PubMed  Google Scholar 

  40. Edwards CE. Reduction of spondylolisthesis. In: DeWald RL, Bridwell KH, editors. The textbook of spinal surgery. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 1991. p. 605–34.

    Google Scholar 

  41. Suk SI, Lee CK, Kim WJ, Lee JH, Cho KJ, Kim HG. Adding posterior lumbar interbody fusion to pedicle screw fixation and posterolateral fusion after decompression in spondylolytic spondylolisthesis. Spine (Phila Pa 1976). 1997;22(2):210–9.

    Article  CAS  PubMed  Google Scholar 

  42. Spruit M, Pavlov PW, Leitao J, De Kleuver M, Anderson PG, Den Boer F. Posterior reduction and anterior lumbar interbody fusion in symptomatic low-grade adult isthmic spondylolisthesis: short-term radiological and functional outcome. Eur Spine J. 2002;11(5):428–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Suk KS, Jeon CH, Park MS, Moon SH, Kim NH, Lee HM. Comparison between posterolateral fusion with pedicle screw fixation and anterior interbody fusion with pedicle screw fixation in adult spondylolytic spondylolisthesis. Yonsei Med J. 2001;42(3):316–23.

    Article  CAS  PubMed  Google Scholar 

  44. Gill G. Long-term follow-up evaluation of a few patients with spondylolisthesis treated by excision of the loose lamina with decompression of the nerve roots without spinal fusion. Clin Orthop Relat Res. 1984;182:215–9.

    Article  Google Scholar 

  45. Hoel RJ, Brenner RM, Polly DW. The challenge of creating lordosis in high-grade dysplastic spondylolisthesis. Neurosurg Clin N Am. 2018;29(3):375–87.

    Article  PubMed  Google Scholar 

  46. Lehman RA Jr, Kuklo TR, Belmont PJ Jr, Andersen RC, Polly DW Jr. Advantage of pedicle screw fixation directed into the apex of the sacral promontory over bicortical fixation: a biomechanical analysis. Spine (Phila Pa 1976). 2002;27(8):806–11.

    Article  PubMed  Google Scholar 

  47. Harms J, Jeszenszky D, Stoltze D, et al. True spondylolisthesis reduction and monosegmental fusion in spondylolisthesis. In: Bridwell KH, Dewald RL, editors. The textbook of spine surgery. 2nd ed. Philadelphia: Lippincott-Raven; 1997. p. 1337–47.

    Google Scholar 

  48. Shufflebarger HL, Geck MJ. High-grade isthmic dysplastic spondylolisthesis: monosegmental surgical treatment. Spine (Phila Pa 1976). 2005;30(Suppl 6):S42–8.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Assaker, R., Wagner, S.C., Shufflebarger, H.L., Lehman, R.A. (2023). Management of High-Grade Spondylolisthesis Including Reduction Techniques. In: Wollowick, A.L., Sarwahi, V. (eds) Spondylolisthesis. Springer, Cham. https://doi.org/10.1007/978-3-031-27253-0_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-27253-0_22

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-27252-3

  • Online ISBN: 978-3-031-27253-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics