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Ultrasound Stimulation of Tendon Healing: Current Strategies and Opportunities for Novel Therapeutic Approaches

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Regenerative Rehabilitation

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

Tendons are mechanosensitive tissues that are critical to musculoskeletal mobility. An in-depth understanding of the mechanisms of tendon injury and healing is crucial to the development of new therapeutic strategies for tendon healing. Tendons do not possess a robust, intrinsic healing response, and conservative and surgical treatments have shown limited efficacy. For chronic tendon injuries (tendinopathies), the principal treatment of choice is exercise-based rehabilitation, which confers improvements in clinical symptoms and function. Therapeutic Ultrasound (TUS) is commonly incorporated within physiotherapy applications and provides pain relief, likely via a thermal modality, to soft skeletal tissues. While numerous animal studies have examined the efficacy of TUS in treating acute tendon injuries, few clinical studies have examined this treatment for chronic tendinopathies. Recently, focused ultrasound (FUS) methods have shown great promise for noninvasive tissue ablation and stimulation of tissue healing but have been minimally explored for musculoskeletal ailments. Precise and customizable therapeutic FUS methods offer the potential to achieve effective, functional tissue healing via thermal and/or mechanical stimulation pathways. This chapter explores the potential of FUS therapies as customizable, noninvasive treatment options for tendon injuries and offers insights into the current state and potential advancements of ultrasound stimulation for tendon healing.

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Authors and Affiliations

  1. Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, USA

    Chitra Meduri, Eli Vlaisavljevich & Vincent M. Wang

  2. Edward Via College of Osteopathic Medicine, Blacksburg, VA, USA

    P. Gunnar Brolinson

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  1. Chitra Meduri
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  2. Eli Vlaisavljevich
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  3. P. Gunnar Brolinson
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  4. Vincent M. Wang
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Correspondence to Vincent M. Wang .

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  1. School of Kinesiology, University of Minnesota, Minneapolis, MN, USA

    Sarah M. Greising

  2. Department of Kinesiology, University of Georgia, Athens, GA, USA

    Jarrod A. Call

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Meduri, C., Vlaisavljevich, E., Brolinson, P.G., Wang, V.M. (2022). Ultrasound Stimulation of Tendon Healing: Current Strategies and Opportunities for Novel Therapeutic Approaches. In: Greising, S.M., Call, J.A. (eds) Regenerative Rehabilitation. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-95884-8_10

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