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Impact of Various Environmental Factors on the Biosynthesis of Alkaloids in Medicinal Plants

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Environmental Challenges and Medicinal Plants

Part of the book series: Environmental Challenges and Solutions ((ECAS))

Abstract

Alkaloids are a group of nitrogenous heterocyclic compounds derived from amino acids, and plants can synthesize them as secondary metabolites. Such compounds play a key role in the life of organisms. Alkaloids can be easily available in our daily food items and act as a consequential element in various pharmaceutical products. Moreover, they have a significant role in the defense mechanism of plants during stress conditions. In this review, we discuss the impact of various stress factors like abiotic stress; potentially toxic element (PTE)-induced stress (cadmium, lead, zinc, chromium); stress caused by salinity, heat, drought, reactive oxygen species, and free radicals; and nutrient scarcity on the synthesis and production of valuable alkaloids in several medicinal plants.

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References

  • Abdel Rahman R, Gomaa SE, Abdelsalam N, El-Din H, El-Wakil MF, Khaled AS, Hassan HM (2013) Effect of sodium chloride on tropane alkaloids accumulation and proline content in Datura metel and D. stramonium callus cultures. Int J Adv Biol Biomed Res 1(2):197–210

    CAS  Google Scholar 

  • Ahmed A, Leete E (1970) Biosynthesis of tropine moiety of Hyoscyamine from δ-N methylornithine. Phytochemistry 9:2345–2347

    Article  Google Scholar 

  • Ahmed AM, Heikal MD, Ali RM (1988) Changes in amino acids and alkaloid contents in Hyoscyamus maticus and Datura stramonium in response to salinization. Phyton 29:137–147

    Google Scholar 

  • Alet AI, Sánchez DH, Ferrando A, Tiburcio AF, Alcazar R, Cuevas JC, Altabella T, Pico FM, Carrasco-Sorli P, Menéndez AB, Ruiz OA (2011) Homeostatic control of polyamine levels under long-term salt stress in Arabidopsis: changes in putrescine content do not alleviate ionic toxicity. Plant Signal Behavior 6(2):237–242

    Article  CAS  Google Scholar 

  • Ali MB, Yu KW, Hahn EJ, Paek KY (2006) Methyl jasmonate and salicylic acid elicitation induces ginsenosides accumulation, enzymatic and non-enzymatic antioxidant in suspension culture Panax ginseng roots in bioreactors. Plant Cell Rep 25(6):613–620

    Article  CAS  PubMed  Google Scholar 

  • Ali RM (1991) Changes in chemical composition of fruits of salinized Datura stramonium. J Islamic Acad Sci 4(4):289–292

    Google Scholar 

  • Ali RM (2000) Role of putrescine in salt tolerance of Atropa belladonna plant. Plant Sci 152:173–179

    Article  CAS  Google Scholar 

  • Ali RM, Abbas HM (2003) Response of salt stressed barley seedlings to phenylurea. Plant Soil Environ 49(4):158–162

    Article  Google Scholar 

  • Alloway BJ (2010) Heavy metals in soil, 3rd edn. John Wiley and Sons, Inc, New York, USA

    Google Scholar 

  • Amirjani MR (2013) Effects of drought stress on the alkaloid contents and growth parameters of Catharanthus roseus. ARPN J Agric Biol Sci 8(11):745–750

    Google Scholar 

  • Anitha S, Kumari BR (2006) Reserpine accumulation in NaCl treated calli of Rauvolfia tetraphylla L. Sci Asia 32:417–419

    Article  CAS  Google Scholar 

  • Arbona V, Manzi M, de Ollas C, Gómez-Cadenas A (2013) Metabolomics as a tool to investigate abiotic stress tolerance in plants. Int J Mol Sci 14:4885–4911

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Asgari Lajayer B, Ghorbanpour M, Nikabadi S (2017) Heavy metals in contaminated environment: Destiny of secondary metabolite biosynthesis, oxidative status and phytoextraction in medicinal plants. Ecotox Environ Saf 145:370–390

    Article  CAS  Google Scholar 

  • Asl KR, Hosseini B, Sharafi A, Palazon J (2019) Influence of nano-zinc oxide on tropane alkaloid production, h6h gene transcription and antioxidant enzyme activity in Hyoscyamus reticulatus L. hairy roots. Eng Life Sci 19(1):73–89

    Article  CAS  PubMed  Google Scholar 

  • Avanci N, Luche D, Goldman G, Goldman M (2010) Jasmonates are phytohormones with multiple functions, including plant defense and reproduction. Genet Mol Res 9(1):484–505

    Article  CAS  PubMed  Google Scholar 

  • Azhar N, Hussain B, Ashraf MY, Abbasi KY (2011) Water stress mediated changes in growth, physiology and secondary metabolites of desi ajwain (Trachyspermum ammi L.). Pak J Bot 43(9):15–19

    CAS  Google Scholar 

  • Battaglia ML, Lee C, Thomason W, Corn J (2018) Yield components and yield responses to defoliation at different row widths. Agron J 110:1–16

    Article  Google Scholar 

  • Baye H, Hymete A (2010) Lead and cadmium accumulation in medicinal plants collected from environmentally different sites. Bull Environ Contam Toxicol 84(2):197–201

    Article  CAS  PubMed  Google Scholar 

  • Benjamin JJ, Lucini L, Jothiramshekar S, Parida A (2019) Metabolomic insights into the mechanisms underlying tolerance to salinity in different halophytes. Plant Physiol Biochem 135:528–545

    Article  CAS  PubMed  Google Scholar 

  • Bettaieb I, Zakhama N, Wannes WA, Kchouk ME, Marzouk B (2009) Water deficit effects on Salvia officinalis fatty acids and essential oils composition. Sci Hortic 120(2):271–275

    Article  CAS  Google Scholar 

  • Bhatla R, Tripathi A (2014) The study of rainfall and temperature variability over Varanasi. Int J Earth Atmos Sci 1:90–94

    Google Scholar 

  • Bielach A, Hrtyan M, Tognetti VB (2017) Plants under stress: involvement of auxin and cytokinin. Int J Mol Sci 18:1427

    Article  CAS  PubMed Central  Google Scholar 

  • Brown MS, Molyneux RJ (1996) Effects of water and mineral nutrient deficiencies on pyrrolizidine alkaloid content of Senecio vulgaris flowers. J Sci Food Agr 70:209–211

    Article  CAS  Google Scholar 

  • Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527–605

    Article  CAS  PubMed  Google Scholar 

  • Cheeseman KH, Slater TF (1993) Review an introduction to free radical biochemistry. Br Med Bull 49(3):481–493

    Article  CAS  PubMed  Google Scholar 

  • Cho Y, Kodjoe E, Puppala N, Wood AJ (2011) Reduced trigonelline accumulation due to rhizobial activity improves grain yield in peanut (Arachis hypogaea L.). Acta Agric Scand B soil. Plant Sci 61(5):395–403

    CAS  Google Scholar 

  • Comporti M (1989) Three models of free radical-induced cell injury. Chem Biol Interact 72:1–56

    Article  CAS  PubMed  Google Scholar 

  • Daryanto S, Wang L, Jacinthe PA (2020) Global synthesis of drought effects on cereal, legume, tuber and root crops production: a review. Agric Water Manag 179:18–33

    Article  Google Scholar 

  • Del Duca S, Tidu V, Bassi R, Esposito C, Serafani Fracassini D (1994) Identification of chlorophyll-a/b proteins as substrates of transglutaminase activity in isolated chloroplasts of Helianthus tuberosus L. Planta 193:283–289

    Article  Google Scholar 

  • Denholm J (2010) Complementary medicine and heavy metal toxicity in Australia. Webmed Central Toxicol 1:WMC00535

    Google Scholar 

  • Dietrich’s N, Feiter U, Wynberg R (2006) Production of traditional medicines: technologies, standards and regulatory issues. In: Commercializing medicinal plants: a southern African guide. Sun Press, Stellenbosch

    Google Scholar 

  • Edreva A, Velikova V, Tsonev T (2008) Stress-protective role of secondary metabolites: diversity of functions and mechanisms. Gen Appl Plant Physiol 34(1–2):67–78

    CAS  Google Scholar 

  • Edreva A, Yordanov I, Kardjieva R, Gesheva E (1998) Heat shock responses of bean plants: involvement of free radicals, antioxidants and free radical/active oxygen scavenging systems. Biol Plant 41:185–191

    Article  CAS  Google Scholar 

  • Edreva A, Yordanov I, Kardjieva R, Hadjiiska E, Gesheva E (1995) Expression of phenylamides in abiotic stress conditions. Bulg J Plant Physiol 21:15–23

    CAS  Google Scholar 

  • El-Sayed M, Verpoorte R (2004) Growth, metabolic profiling and enzymes activities of Catharanthus roseus seedlings treated with plant growth regulators. Plant Growth Regul 44(1):53–58

    Article  CAS  Google Scholar 

  • Ezz E, Aziz EE, Hendawy SF, Omer EA (2009) Response of Thymus vulgaris L. to salt stress and alar (B9) in newly reclaimed soil. J Appl Sci Res 5(12):2165–2170

    Google Scholar 

  • Flores HE, Galston AW (2011) Polyamines and plant stress: activation of putrescine biosynthesis by osmotic shock. Sci 24(217):1259–1261

    Google Scholar 

  • Foster SA, Walters DR (1991) Polyamine concentrations and arginine decarboxylase activity in wheat exposed to osmotic stress. Plant Physiol 82:185–190

    Article  CAS  Google Scholar 

  • Frischknecht PM, Schuhmacher K, Müller-Schärer H, Baumann TWJ (2001) Phenotypic plasticity of Senecio vulgaris from contrasting habitat types: growth and pyrrolizidine alkaloid formation. Chem Ecol 27(2):343–358

    Article  CAS  Google Scholar 

  • Georgiev MI, Weber J, Maciuk A (2009) Bioprocessing of plant cell cultures for mass production of targeted compounds. Appl Microbiol Biotechnol 83:809–823

    Article  CAS  PubMed  Google Scholar 

  • Ghasemi M, Modarresi M, Babaeian Jelodar N, Bagheri N, Jamali A (2016) The evaluation of exogenous application of salicylic acid on physiological characteristics, proline and essential oil content of chamomile (Matricaria chamomilla L.) under normal and heat stress conditions. Agriculture 6(3):31

    Article  CAS  Google Scholar 

  • Gray SB, Brady SM (2016) Plant developmental responses to climate change. Dev Biol 419:64–77

    Article  CAS  PubMed  Google Scholar 

  • Halliwell B, Gutteridge JC (1992) Biologically relevant metal ion dependent hydroxyl radical generation—an update. FEBS Lett 307:108–112

    Article  CAS  PubMed  Google Scholar 

  • Halliwell B, Gutteridge JC (1995) The definition and measurement of antioxidants in biological systems. Free Radic Biol Med 18:125–126

    Article  CAS  PubMed  Google Scholar 

  • Hartmann T, Zimmer M (1986) Organ-specific distribution and accumulation of pyrrolizidine alkaloids during the life-history of 2 annual Senecio species. J Plant Physiol 122:67–80

    Article  CAS  Google Scholar 

  • Hilal M, Zennof AM, Ponessa G, Moreno H, Massa E (1998) Salinity stress alters the temporal patterns of xylem differentiation and alternative oxidase expression in developing soybean roots. Plant Physiol 117(2):695–701

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hol WHG, van Veen JA (2002) Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth. J Chem Ecol 28:1763–1772

    Article  CAS  PubMed  Google Scholar 

  • Hol WHG, Vrieling K, van Veen JA (2003) Nutrients decrease pyrrolizidine alkaloid concentrations in Senecio jacobaea. New Phytol 158:175–181

    Article  CAS  Google Scholar 

  • Idrees M, Naeem M, Aftab T (2011) Salicylic acid mitigates salinity stress by improving antioxidant defence system and enhances vincristine and vinblastine alkaloids production in periwinkle [Catharanthus roseus (L.) G. Don]. Acta Physiol Plant 33:987–999

    Article  CAS  Google Scholar 

  • Jaleel CA, Manivannan P, Sankar B, Kishorekumar A, Panneerselvam R (2007a) Calcium chloride effects on salinity-induced oxidative stress, proline metabolism and indole alkaloid accumulation in Catharanthus roseus. C R Biol 330:674–683

    Article  CAS  PubMed  Google Scholar 

  • Jaleel CA, Manivannan P, Sankar B, Kishorekumar A, Gopi R, Somasundaram R, Panneerselvam R (2007b) Water deficit stress mitigation by calcium chloride in Catharanthus roseus: effects on oxidative stress, proline metabolism and indole alkaloid accumulation. Colloids Surf B Biointerfaces 60(1):110–116

    Article  CAS  PubMed  Google Scholar 

  • Jaleel CA, Manivannan P, Lakshmanan G, Gomathinayagam M, Panneerselvam R (2008) Alterations in morphological parameters and photosynthetic pigment responses of Catharanthus roseus under soil water deficits. Colloids Surf B Biointerfaces 61(2):298–303

    Article  CAS  PubMed  Google Scholar 

  • Jing-Yan WA, Zhao-Pu LI (2010) Alkaloid accumulation in Catharanthus roseus increases with addition of seawater salts to the nutrient solution. Pedosphere 20(6):718–724

    Article  Google Scholar 

  • Joosten L, Mulder PPJ, Klinkhamer PGL (2009) Soil-borne microorganisms and soil-type affect pyrrolizidine alkaloids in Jacobaea vulgaris. Plant Soil 325:133–143

    Article  CAS  Google Scholar 

  • Joshi N (2015) Influence of light and temperature on secondary metabolite accumulation in callus cultures of Helicteres isora L. IOSR J Environ Sci Toxicol Food Technol 1(1):2319–2399

    Google Scholar 

  • Kang SM, Jung HY, Kang YM, Yun DJ, Bahk JD, Yang JK, Choi MS (2004) Effects of methyl jasmonate and salicylic acid on the production of tropane alkaloids and the expression of PMT and H6H in adventitious root cultures of Scopolia perviflora. Plant Sci 166:745–751

    Article  CAS  Google Scholar 

  • Karadge B, Gaikwad P (2003) Influence of sodium chloride salinity on growth and organic constituents of Catharanthus roseus G. Don Indian J Plant Physiol 8(4):392–397

    Google Scholar 

  • Kaur G, Asthir B (2017) Molecular responses to drought stress in plants. Biol Plant 61:201–209

    Article  CAS  Google Scholar 

  • Kirk H, Vrieling K, van der Meijden E (2009) Plant hybridization and secondary metabolite expression: a case study of pyrrolizidine alkaloids in the genus Senecio. In: Kirk H (ed) Natural hybridization between Senecio jacobae and Senecio aquaticus: ecological outcomes and evolutionary consequences. Dissertation. Leiden University

    Google Scholar 

  • Koricheva J (1999) Interpreting phenotypic variation in plant allelochemistry: problems with the use of concentrations. Oecologia 119(4):467–473

    Article  PubMed  Google Scholar 

  • Kosalec I, Cvek J, Tomić S (2009) Contaminants of medicinal herbs and herbal: products. Arch Ind Hyg Toxicol 60(4):485–501

    CAS  Google Scholar 

  • Lawlor DW, Cornic G (2002) Photosynthetic carbon assimilation and associated metabolism in relation to water deficits in higher plants. Plant Cell Environ 25(2):275–294

    Article  CAS  PubMed  Google Scholar 

  • Li Q, Cai S, Mo C, Chu B, Peng L, Yang F (2010) Toxic effects of heavy metals and their accumulation in vegetables grown in a saline soil. Ecotoxicol Environ Saf 73(1):84–88

    Article  CAS  PubMed  Google Scholar 

  • Lloyd RV, Hanna PM, Mason RP (1997) The origin of the hydroxyl radical oxygen in the Fenton reaction. Free Radic Biol Med 22:885–888

    Article  CAS  PubMed  Google Scholar 

  • Lopez-Garcia MC, Maillet J (2005) Biological characteristics of an invasive south African species. Biol Invasions 7:181–194

    Article  Google Scholar 

  • Macel M, Klinkhamer PGL (2010) Chemotype of Senecio jacobaea affects damage by pathogens and insect herbivores in the field. Evol Ecol 24:237–250

    Article  Google Scholar 

  • Magedans YVS, Matsuura HN, Tasca RAJC (2017) Accumulation of the antioxidant alkaloid brachycerine from Psychotria brachyceras Müll. Arg. is increased by heat and contributes to oxidative stress mitigation. Environ Exp Bot 143:185–193

    Article  CAS  Google Scholar 

  • Malarz J, Stojakowska A, Kisiel W (2007) Effect of methyl jasmonate and salicylic acid on sesquiterpene lactone accumulation in hairy roots of Cichorium intybus. Acta Physiol Plant 29:127–132

    Article  CAS  Google Scholar 

  • Marciniak P, Adamski Z, Bednarz P, Slocinska M, Ziemnicki K, Lelario F, Scrano L, Bufo SA (2010) Cardioinhibitory properties of potato glycoalkaloids in beetles. Bull Environ Contam Toxicol 84(2):153–156

    Article  CAS  PubMed  Google Scholar 

  • Matsuura HN, Fett-Neto AG (2013) The major indole alkaloid N, b-D-glucopyranosyl vincosamide from leaves of Psychotria leiocarpa Cham. & Schltdl. Is not an antifeedant but shows broad antioxidant activity. Nat Prod Res 27:402–411

    Article  CAS  PubMed  Google Scholar 

  • Matsuura HN, Porto DD, Fett-Neto AG (2013) Bioactive alkaloids from south American psychotria and related rubiaceae. In: Ramawat KG, Merillon JM (eds) Natural products, 1st edn. Springer, Berlin, pp 119–147

    Chapter  Google Scholar 

  • Mattocks R (1986) Chemistry and toxicology of pyrrolizidine alkaloids. Academic Press, London, pp 42–45

    Google Scholar 

  • Megateli S, Semsari S, Couderchet M (2009) Toxicity and removal of heavy metals (cadmium, copper, and zinc) by Lemna gibba. Ecotoxicol Environ Saf 72(6):1774–1780

    Article  CAS  PubMed  Google Scholar 

  • Minorsky PV (2002) Trigonelline: a diverse regulator in plants. Plant Physiol 128(1):7–8

    Article  CAS  PubMed Central  Google Scholar 

  • Moattar F, Modabberi S, Sadough MB (2010) Origin and concentrations of heavy metals in agricultural land around aluminum industrial complex. J Food Agric Environ 8(3–4):1237–1240

    Google Scholar 

  • Montiel G, Zarei A, Körbes AP, Memelink J (2011) The jasmonate-responsive element from the ORCA3 promoter from Catharanthus roseus is active in Arabidopsis and is controlled by the transcriptionfactor AtMYC2. Plant Cell Physiol 52(3):578–587

    Article  CAS  PubMed  Google Scholar 

  • Morison JIL, Lawlor DW (1999) Interactions between increasing CO2 concentration and temperature on plant growth. Plant Cell Environ 22:659–682

    Article  CAS  Google Scholar 

  • Nisi R, Paradiso A, De Garab L, D’Amico L, Caretto S (2010) Cultivation of Arabidopsis cell cultures in a stirred bioreactor at variable oxygen levels: influence on tocopherol production. Plant Biosyst 144:721–724

    Article  Google Scholar 

  • O’Connell E (2017) Towards adaptation of water resource systems to climatic and socio-economic Chang. Water Resour Manag 31:2965–2984

    Article  Google Scholar 

  • Osakabe Y, Osakabe K, Shinozaki K, Tran LSP (2014) Response of plants to water stress. Front Plant Sci 5:86

    Article  PubMed  PubMed Central  Google Scholar 

  • Osman ME, Elfeky SS, El Soud KA, Hasan AM (2007) Response of Catharanthus roseus shoots to salinity and drought in relation to vincristine alkaloid content. Asian J Plant Sci 6:1223–1228

    Article  CAS  Google Scholar 

  • Pandey S, Gupta K, Mukherjee AK (2007) Impact of cadmium and lead on Catharanthus roseus - a phytoremediation study. J Environ Biol 28(3):655

    CAS  PubMed  Google Scholar 

  • Pandey S (2017) Cultivation under stress conditions. In: Naeem M, Aftab T, Khan M (eds) Catharanthus roseus. Springer, Cham, pp 383–397

    Chapter  Google Scholar 

  • Passioura JB, Angus JF (2010) Improving productivity of crops in water-limited environments. Adv Agron 106:37–75

    Article  Google Scholar 

  • Poorter H, Nagel O (2000) The role of biomass allocation in the growth response of plants to different levels of light, CO2, nutrients and water: a quantitative review. Aust J Plant Physiol 27:595–607

    CAS  Google Scholar 

  • Prins AH, Vrieling K, Klinkhamer PGL (1990) Flowering behavior of Senecio jacobaea–effects of nutrient availability and size-dependent vernalization. Oikos 59:248–252

    Article  Google Scholar 

  • Qasem JR, Hill TA (1995) Growth, development and nutrient accumulation in Senecio vulgaris L. and Chenopodium album L. Weed Res 35:187–196

    Article  Google Scholar 

  • Radford IJ, Cousens RD (2000) Invasiveness and comparative life-history traits of exotic and indigenous Senecio species in Australia. Oecologia 125:531–542

    Article  PubMed  Google Scholar 

  • Rai V, Tandon PK, Khatoon S (2014) Effect of chromium on antioxidant potential of Catharanthus roseus varieties and production of their anticancer alkaloids: vincristine and vinblastine. Biomed Res Int 2014:934182

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rai V, Khatoon S, Bisht S, Mehrotra S (2005) Effect of cadmium on growth, ultramorphology of leaf and secondary metabolites of Phyllanthus amarus Schum. And Thonn. Chemosphere 61(11):1644–1650

    Article  CAS  PubMed  Google Scholar 

  • Said-Al Ahl HAH, Omer EA (2011) Medicinal and aromatic plants production under salt stress. Herba Pol 57:72–87

    Google Scholar 

  • Seiler N, Raul F (2005) Polyamines and apoptosis. J Cell Mol Med 9:623–642

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Selmar D (2008) Potential of salt and drought stress to increase pharmaceutical significant secondary compounds in plants. Landbauforschung Volkenrode 58(1/2):139

    Google Scholar 

  • Shriya MS, Kumari A, Choudhary S (2019) Temperature stress mediated consequences on physiology and secondary metabolites of Datura Stramonium (L.). Int J Pharm Sci Res 58:3085–3091

    Google Scholar 

  • Sosa L, Llanes A, Reinoso H, Reginato M, Luna V (2005) Osmotic and specific ion effects on the germination of Prosopis strombulifera. Ann Bot 96(2):261–267

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Springate DA, Kover PX (2014) Plant responses to elevated temperatures: a field study on phenological sensitivity and fitness responses to simulated climate warming. Glob Change Biol 20:456–465

    Article  Google Scholar 

  • Srivastava NK, Srivastava AK (2010) Influence of some heavy metals on growth, alkaloid content and composition in Catharanthus roseus L. Indian J Pharm Sci 72(6):775–778

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sultan S (2014) Reviewing the protective role of antioxidants in oxidative stress caused by free radicals. Asian Pac J Health Sci 1(4):401–406

    Article  Google Scholar 

  • Szabo B, Tyihak E, Szaba G, Botz L (2003) Mycotoxin and drought stress induced change of alkaloid content of Papaver somniferum plantlets. Acta Bot Hung 45(3–4):409–417

    Article  CAS  Google Scholar 

  • Tang W, Newton JR (2005) Polyamines reduced salt induced oxidative damage by increasing the activities of antioxidant enzymes and decreasing lipid peroxidation in Virginia pine. Plant Growth Regul 46:31–43

    Article  CAS  Google Scholar 

  • Thomsen MG, Galambosi B, Galambosi Z, Uusitalo M, Mordal R, Heinonen A (2012) Harvest time and drying temperature effect on secondary metabolites in Rhodiola rosea. Acta Hortic 955:243–252

    Article  Google Scholar 

  • Tramontano WA, Jouve D (1997) Trigonelline accumulation in salt stressed legumes and the role of other osmoregulators as cell cycle control agents. Phytochemistry 44:1037–1040

    Article  CAS  Google Scholar 

  • van der Meijden E, van Bemmelen M, Kooi R (1984) Nutritional quality and chemical defense in the ragwort-cinnabar moth interaction. J Anim Ecol 53:443–453

    Article  Google Scholar 

  • Verpoorte R, Contin A, Memelink J (2002) Biotechnology for the production of plant secondary metabolites. Phytochemistry 1:13–25

    Article  CAS  Google Scholar 

  • Wahid A, Gelani S, Ashraf M, Foolad MR (2007) Heat tolerance in plants: an overview. Environ Exp Bot 61:199–223

    Article  Google Scholar 

  • Wani SH, Sandhu JS, Gosal SS (2008) Genetic engineering of crop plants for abiotic stress tolerance. In: Malik CP, Kaur B, Wadhwani C (eds) Advanced topics in plant biotechnology and plant biology. MD Publications, New Delhi, pp 149–183

    Google Scholar 

  • World Health Organization (WHO) (1998) Quality control methods for medicinal plant materials, Geneva

    Google Scholar 

  • Wippich C, Wink M (1985) Biological properties of alkaloids. Influence of quinolizidine alkaloids and gramine on the germination and development of powdery mildew, Erysiphe graminist f.sp. hordei. Experientia 41:1477–1479

    Article  CAS  Google Scholar 

  • Young IS, Woodside JV (2001) Review antioxidants in health and disease. J Clin Pathol 54(3):176–186

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yu ZZ, Fu CX, Han YS, Li YX, Zhao DX (2006) Salicylic acid enhances jaceosidin and syringin production in cell cultures of Saussurea medusa. Biotechnol Lett 28(13):1027–1031

    Article  CAS  PubMed  Google Scholar 

  • Yuyama S, Suzuki T (1991) The excretion of N'- methyl-2-pyridone-5-carboxylic acid and related compounds in human subjects after oral administration of nicotinic acid, trigonelline, and N'-methyl-2-pyridone-5-carboxylic acid. Adv Exp Med Biol 294:475–479

    Article  CAS  PubMed  Google Scholar 

  • Zandalinas SI, Fritschi FB, Mittler R (2020) Signal transduction networks during stress combination. J Exp Bot 71:1734–1741

    Article  CAS  PubMed  Google Scholar 

  • Zheljazkov VD, Nielsen NE (1996) Effect of heavy metals on peppermint and cornmint. Plant Soil 178(1):59–66

    Article  CAS  Google Scholar 

  • Zheljazkov VD, Craker LE, Xing B (2006) Effects of cd, Pb, and cu on growth and essential oil contents in dill, peppermint, and basil. Environ Exp Bot 58(1):9–16

    Article  CAS  Google Scholar 

  • Zheng Z, Wu M (2004) Cadmium treatment enhances the production of alkaloid secondary metabolites in Catharanthus roseus. Plant Sci 166:507–514

    Article  CAS  Google Scholar 

  • Zhou M, Shao J, Tang Y (2009) Production and metabolic engineering of terpenoid indole alkaloids in cell cultures of the medicinal plant Catharanthus roseus (L.) G. Don (Madagascar periwinkle). Biotechnol Appl Biochem 52:313–323

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Biology, Islamic Azad University of Urmia, Urmia, Iran

    Arian Amirifar

  2. Department of Soil Science, Faculty of Agriculture, University of Tabriz, Tabriz, Iran

    Arash Hemati & Behnam Asgari Lajayer

  3. Division of Agronomy and Soil Science, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India

    Janhvi Pandey

  4. Faculty of Agriculture, Dalhousie University, Truro, NS, Canada

    Tess Astatkie

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  1. Arian Amirifar
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  2. Arash Hemati
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  3. Behnam Asgari Lajayer
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  4. Janhvi Pandey
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  5. Tess Astatkie
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Correspondence to Behnam Asgari Lajayer .

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  1. Department of Botany, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    Tariq Aftab

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Amirifar, A., Hemati, A., Asgari Lajayer, B., Pandey, J., Astatkie, T. (2022). Impact of Various Environmental Factors on the Biosynthesis of Alkaloids in Medicinal Plants. In: Aftab, T. (eds) Environmental Challenges and Medicinal Plants. Environmental Challenges and Solutions. Springer, Cham. https://doi.org/10.1007/978-3-030-92050-0_9

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