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Regulation of Expression of Transcription Factors for Enhanced Secondary Metabolites Production Under Challenging Conditions

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Environmental Challenges and Medicinal Plants

Part of the book series: Environmental Challenges and Solutions ((ECAS))

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Abstract

Secondary metabolites are synthesized by plants when they are developing or responding to biotic and abiotic environmental stimuli, such as pathogen attack, light, stress, etc., that are used for pharmaceutical production or as nutritional ingredients. Research on secondary metabolites has received particular attention due to their benefits to health and in other industries. The study on plant genetics revealed transcription factors as important molecular tools for increasing the production of useful compounds by the metabolic engineering. In response to internal or external signals, transcription factors bind to the specific gene promoters, activating or suppressing the enzyme coding gene expression, and often form complexes that include others. By modifying genes that encode biochemical enzymes or regulatory proteins, different pathways could be altered. In addition to reducing the time-consuming process of investigating all the enzymatic steps of a poorly understood biosynthetic pathway, specific transcription factors would also reduce the costs of product development. This review includes regulation of the biosynthetic pathways of some important secondary metabolite classes with the knowledge of specific genes, transcription factors, and their modifications in different model plant species for the enhancement of the secondary metabolite contents.

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Authors and Affiliations

  1. Department of Life Sciences, Presidency University, Kolkata, West Bengal, India

    Protha Biswas, Mimosa Ghorai & Abhijit Dey

  2. Department of Biotechnology, Lovely Professional University, Phagwara, Punjab, India

    Devendra Kumar Pandey

  3. Department of Microbiology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India

    Joginder Singh

  4. Department of Biological Sciences, Al-Hussein Bin Talal University, Maan, Jordon, UAE

    Abdel Rahman Al-Tawaha

  5. Department of Biochemistry, Mus Alparslan University, Muş, Turkey

    Ercan Bursal

  6. Department of Biotechnology, Modern College, Ganeshkhind, Pune, India

    Vinay Kumar

  7. Department of Biotechnology, Manipur University, Imphal, Manipur, India

    Potshangbam Nongdam

  8. Department of Plant Biology and Biotechnology, Kanchi Mamunivar Government Institute for Postgraduate Studies and Research, Pondicherry, India

    Mahipal S. Shekhawat

  9. Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt

    Gaber El-Saber Batiha

  10. Department of Botany, Gauhati University, Guwahati, Assam, India

    Arabinda Ghosh

  11. Department of Botany, Banaras Hindu University Plant Physiology, Varanasi, UP, India

    Padmanabh Dwivedi

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    Tariq Aftab

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Biswas, P. et al. (2022). Regulation of Expression of Transcription Factors for Enhanced Secondary Metabolites Production Under Challenging Conditions. In: Aftab, T. (eds) Environmental Challenges and Medicinal Plants. Environmental Challenges and Solutions. Springer, Cham. https://doi.org/10.1007/978-3-030-92050-0_10

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