Abstract
The grapefruit is one of the most produced and consumed citrus fruits in the world, with an average annual production of 7 million tonnes. It has become increasingly popular, as it is considered a low-calorie fruit, rich in vitamins, minerals and many other valuable nutrients (flavonoids, carotenoids, essential oils…). Over half a million tonnes of grapefruit undergo processing, mainly into juice, which generates large amounts of wastes (peel, seeds, pulp and leftover membrane), since only 50% of the fruit is used in this manufacturing process. Today, these wastes are mostly discarded or used as cattle feed. These practices are unfortunate, as grapefruit processing wastes could be a source of high-added economic value. Indeed, they represent a source of dietary fibers, sugars, essential oils, flavonoids and carotenoids, valuable in various industrial sectors (energetic, agricultural, pharmaceutical, cosmetic and food). Thus, if grapefruit wastes can be used to produce biogas or bio-energy, to fertilize soil or as biosorbent in wastewater treatment, the recovery of their bioactive compounds (e.g. pectin, essential oils, carotenoids and flavonoids) could be also highly pertinent, as these compounds present a wide spectrum of technological properties and/or health benefits. Extraction processes usually adopted to recover those compounds use organic solvents, high temperatures and long extraction times, which are considered to generate a high environmental impact. As a result, in recent decades, different operating strategies have been developed (ultrasound-, microwave-, pulsed electric field-assisted extraction, and supercritical fluids), with the objective of increasing extraction yields while reducing use of resources. However, most of them have still economic or technological limitations that prevent their development in small and medium-sized enterprises. The present chapter expands on the aforementioned aspects of grapefruit wastes, with the objective of demonstrating their high re-use potential. This chapter presents the potential valorization of grapefruit wastes in food and non-food applications and offers a brief overview of the main emergent extraction technologies.
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Abbreviations
- 6,7-DHB:
-
6,7-Dihydroxybergamottin
- C:
-
Covered
- DF:
-
Dietary fiber
- DW:
-
Dry weight
- EAE:
-
Enzyme-assisted extraction
- EO:
-
Essential oils
- FA:
-
Fatty acids
- FW:
-
Fresh weight
- GF:
-
Grapefruit
- GFSE:
-
Grapefruit seed extract
- GPW:
-
Grapefruit processing wastes
- GRAS:
-
Generally recognized as safe
- IDF:
-
Insoluble dietary fiber
- M:
-
Marsh white
- MAE:
-
Microwave-assisted extraction
- MT:
-
Million Tonnes
- NC:
-
Non-covered
- PEF:
-
Pulsed electric field
- RR:
-
Ruby red
- SD:
-
Standard deviation
- SDF:
-
Soluble dietary fiber
- SFE:
-
Supercritical fluid extraction
- SR:
-
Star Ruby
- UAE:
-
Ultrasound-assisted extraction
- WPI:
-
Whey protein isolate
References
Adeyeye, E. I., & Adesina, A. J. (2015). Citrus seeds oils as sources of quality edible oils. International Journal of Current Microbiology and Applied Sciences, 4(5), 537–554.
Ahmad, M. M., Rehman, S., Iqbal, Z., Anjum, F., & Sultan, J. (2006). Genetic variability to essential oil composition in four citrus fruit species. Pakistan Journal of Botany, 38(2), 319–324.
Ahmed, S., Rattanpal, H. S., Gul, K., Dar, R. A., & Sharma, A. (2019). Chemical composition, antioxidant activity and GC-MS analysis of juice and peel oil of grapefruit varieties cultivated in India. Journal of Integrative Agriculture, 18(7), 1634–1642. https://doi.org/10.1016/S2095-3119(19)62602-X
Ajayi-Moses, O. B., Ogidi, C. O., & Akinyele, B. J. (2019). Bioactivity of Citrus essential oils (CEOs) against microorganisms associated with spoilage of some fruits. Chemical and Biological Technologies in Agriculture, 6(1), 22. https://doi.org/10.1186/s40538-019-0160-5
Ajewole, K., & Adeyeye, A. (1993). Characterisation of Nigerian citrus seed oils. Food Chemistry, 47(1), 77–78. https://doi.org/10.1016/0308-8146(93)90306-Z
Alam, M. A., Subhan, N., Rahman, M. M., Uddin, S. J., Reza, H. M., & Sarker, S. D. (2014). Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Advances in Nutrition, 5(4), 404–417. https://doi.org/10.3945/an.113.005603
Alam, M., Kauter, K., & Brown, L. (2013). Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. Nutrients, 5(3), 637–650. https://doi.org/10.3390/nu5030637
Alexandre, E. M. C., Moreira, S. A., Castro, L. M. G., Pintado, M., & Saraiva, J. A. (2018). Emerging technologies to extract high added value compounds from fruit residues: Sub/supercritical, ultrasound-, and enzyme-assisted extractions. Food Reviews International, 34(6), 581–612. https://doi.org/10.1080/87559129.2017.1359842
Aloui, H., Khwaldia, K., Sánchez-González, L., Muneret, L., Jeandel, C., Hamdi, M., & Desobry, S. (2014). Alginate coatings containing grapefruit essential oil or grapefruit seed extract for grapes preservation. International Journal of Food Science & Technology, 49(4), 952–959. https://doi.org/10.1111/ijfs.12387
Alquezar, B., Rodrigo, M. J., Lado, J., & Zacarías, L. (2013). A comparative physiological and transcriptional study of carotenoid biosynthesis in white and red grapefruit (Citrus paradisi Macf.). Tree Genetics and Genomes, 9(5), 1257–1269. https://doi.org/10.1007/s11295-013-0635-7
Anticona, M., Blesa, J., Frigola, A., & Esteve, M. J. (2020). High biological value compounds extraction from citrus waste with non-conventional methods. Foods, 9(6), 811. https://doi.org/10.3390/foods9060811
Anwar, F., Naseer, R., Bhanger, M. I., Ashraf, S., Talpur, F. N., & Aladedunye, F. A. (2008). Physico-chemical characteristics of citrus seeds and seed oils from Pakistan. Journal of the American Oil Chemists’ Society, 85(4), 321–330. https://doi.org/10.1007/s11746-008-1204-3
Aydeniz Güneşer, B., & Yilmaz, E. (2018). Bitterness reduction of cold pressed grapefruit seed oil by adsorbent treatment. European Journal of Lipid Science and Technology, 120(5), 1700308. https://doi.org/10.1002/ejlt.201700308
Aydeniz-Guneser, B., & Guneser, O. (2020). Cold pressed grapefruit (Citrus paradisi L.) oil. In Cold pressed oils (pp. 497–513). Elsevier. doi: https://doi.org/10.1016/B978-0-12-818188-1.00045-1
Bagherian, H., Zokaee Ashtiani, F., Fouladitajar, A., & Mohtashamy, M. (2011). Comparisons between conventional, microwave- and ultrasound-assisted methods for extraction of pectin from grapefruit. Chemical Engineering and Processing: Process Intensification, 50(11), 1237–1243. https://doi.org/10.1016/j.cep.2011.08.002
Barroso, M. A. T., Moura Fe, J. A., Whiting, F. M., Brown, W. H., & Stull, J. W. (1972). Grapefruit seed oil sterols. Journal of the American Oil Chemists’ Society, 49(1), 85–86. https://doi.org/10.1007/BF02545150
Bharti, S., Rani, N., Krishnamurthy, B., & Arya, D. S. (2014). Preclinical evidence for the pharmacological actions of naringin: A review. Planta Medica, 80(6), 437–451. https://doi.org/10.1055/s-0034-1368351
Bilgiçli, N., Aktas, K., & Levent, H. (2014). Utilization of citrus albedo in Tarhana production. Journal of Food and Nutrition Research, 53(2), 162–170.
Boluda-Aguilar, M., & López-Gómez, A. (2013). Production of bioethanol by fermentation of lemon (Citrus limon L.) peel wastes pretreated with steam explosion. Industrial Crops and Products, 41, 188–197. https://doi.org/10.1016/j.indcrop.2012.04.031
Bousbia, N., Vian, M. A., Ferhat, M. A., Meklati, B. Y., & Chemat, F. (2009). A new process for extraction of essential oil from Citrus peels: Microwave hydrodiffusion and gravity. Journal of Food Engineering, 90(3), 409–413. https://doi.org/10.1016/j.jfoodeng.2008.06.034
Calder, P. C. (2015). Functional roles of fatty acids and their effects on human health. Journal of Parenteral and Enteral Nutrition, 39(1S), 18S–32S. https://doi.org/10.1177/0148607115595980
Carrasquero, A., Salazar, M., & Navas Petra, B. (1998). Antioxidant activity of grapefruit seed extract on vegetable oils. Journal of the Science of Food and Agriculture, 77(4), 463–467.
Cerda, J. J. (1988). The role of grapefruit pectin in health and disease. Transactions of the American Clinical and Climatological Association, 99, 203–213.
Cerda, J. J., Robbins, F. L., Burgin, C. W., Baumgartner, T. G., & Rice, R. W. (1988). The effects of grapefruit pectin on patients at risk for coronary heart disease without altering diet or lifestyle. Clinical Cardiology, 11(9), 589–594. https://doi.org/10.1002/clc.4960110902
Chakraborty, S., & Basu, S. (2017). Multi-functional activities of citrus flavonoid narirutin in Alzheimer’s disease therapeutics: An integrated screening approach and in vitro validation. International Journal of Biological Macromolecules, 103, 733–743. https://doi.org/10.1016/j.ijbiomac.2017.05.110
Chávez-González, M. L., López-López, L. I., Rodríguez-Herrera, R., Contreras-Esquivel, J. C., & Aguilar, C. N. (2016). Enzyme-assisted extraction of citrus essential oil. Chemical Papers, 70(4), 412–417. https://doi.org/10.1515/chempap-2015-0234
Chávez-González, M. L., Sepúlveda, L., Verma, D. K., Luna-García, H. A., Rodríguez-Durán, L. V., Ilina, A., & Aguilar, C. N. (2020). Conventional and emerging extraction processes of flavonoids. Processes, 8(4), 434. https://doi.org/10.3390/pr8040434
Chen, J., Lu, M., Jing, Y., & Dong, J. (2006). The synthesis of L-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells. Bioorganic & Medicinal Chemistry, 14(19), 6539–6547. https://doi.org/10.1016/j.bmc.2006.06.013
Chen, R., Qi, Q.-L., Wang, M.-T., & Li, Q.-Y. (2016). Therapeutic potential of naringin: An overview. Pharmaceutical Biology, 54(12), 3203–3210. https://doi.org/10.1080/13880209.2016.1216131
Choi, I. S., Lee, Y. G., Khanal, S. K., Park, B. J., & Bae, H.-J. (2015). A low-energy, cost-effective approach to fruit and citrus peel waste processing for bioethanol production. Applied Energy, 140, 65–74. https://doi.org/10.1016/j.apenergy.2014.11.070
Chtourou, Y., Aouey, B., Aroui, S., Kebieche, M., & Fetoui, H. (2016). Anti-apoptotic and anti-inflammatory effects of naringin on cisplatin-induced renal injury in the rat. Chemico-Biological Interactions, 243, 1–9. https://doi.org/10.1016/j.cbi.2015.11.019
Chudnovskiy, R., Thompson, A., Tharp, K., Hellerstein, M., Napoli, J. L., & Stahl, A. (2014). Consumption of clarified grapefruit juice ameliorates high-fat diet induced insulin resistance and weight gain in mice. PLoS One, 9(10), e108408. https://doi.org/10.1371/journal.pone.0108408
Ciğeroğlu, Z., Bayramoğlu, M., Kırbaşlar, Ş. İ., & Şahin, S. (2020). Comparison of microwave-assisted techniques for the extraction of antioxidants from Citrus paradisi Macf. biowastes. Journal of Food Science and Technology. https://doi.org/10.1007/s13197-020-04632-x
Cockell, C. S., & Knowland, J. (2007). Ultraviolet radiation screening compounds. Biological Reviews, 74(3), 311–345. https://doi.org/10.1111/j.1469-185X.1999.tb00189.x
Combo, A. M. M., Aguedo, M., & Paquot, M. (2011). Les oligosaccharides pectiques: Production et applications possibles. Biotechnologie, Agronomie, Société et Environnement, 15(1), 153–164.
Cristóbal-Luna, J. M., Álvarez-González, I., Madrigal-Bujaidar, E., & Chamorro-Cevallos, G. (2018). Grapefruit and its biomedical, antigenotoxic and chemopreventive properties. Food and Chemical Toxicology, 112, 224–234. https://doi.org/10.1016/j.fct.2017.12.038
Csupor, D., Micsinay, Á., Máthé, I., Horváth-Boros, K., Kiss, T., & Hohmann, J. (2018). Planar chromatography in the quality control of adulterated Citrus paradisi seed extract-containing products. JPC – Journal of Planar Chromatography – Modern TLC, 31(1), 23–27. https://doi.org/10.1556/1006.2018.31.1.3
Cui, B., Liu, S., Wang, Q., & Lin, X. (2012). Effect of β-Carotene on immunity function and tumour growth in hepatocellular carcinoma rats. Molecules, 17(7), 8595–8603. https://doi.org/10.3390/molecules17078595
Cvetni, Z., & Vladimir-Kne, S. (2004). Antimicrobial activity of grapefruit seed and pulp ethanolic extract. Acta Pharmaceutica, 54(3), 243–250.
Czech, A., Zarycka, E., Yanovych, D., Zasadna, Z., Grzegorczyk, I., & Kłys, S. (2020). Mineral content of the pulp and peel of various citrus fruit cultivars. Biological Trace Element Research, 193(2), 555–563. https://doi.org/10.1007/s12011-019-01727-1
Dai, F.-J., & Chau, C.-F. (2017). Classification and regulatory perspectives of dietary fiber. Journal of Food and Drug Analysis, 25(1), 37–42. https://doi.org/10.1016/j.jfda.2016.09.006
De Castro, W. V., Mertens-Talcott, S., Rubner, A., Butterweck, V., & Derendorf, H. (2006). Variation of flavonoids and furanocoumarins in grapefruit juices: A potential source of variability in grapefruit juice−drug interaction studies. Journal of Agricultural and Food Chemistry, 54(1), 249–255. https://doi.org/10.1021/jf0516944
De Vries, J., Prosky, L., Li, B., & Cho, S. (1999). A historical perspective on defining dietary fiber. Cereal Foods World, 44, 367–369.
Del Rio, J. A., Fuster, M. D., Sabater, F., Porras, I., Garcia-Lidon, A., & Ortuño, A. (1997). Selection of citrus varieties highly productive for the neohesperidin dihydrochalcone precursor. Food Chemistry, 59(3), 433–437. https://doi.org/10.1016/S0308-8146(96)00303-2
Del Río, J. A., & Ortuño, A. (1994). Citrus paradisi Macf. (Grapefruit): In vitro culture and the bioproduction of sesquiterpenes nootkatone, valencene, and other secondary metabolites. In Y. P. S. Bajaj (Ed.), Medicinal and aromatic plants VII (pp. 123–138). Springer. https://doi.org/10.1007/978-3-662-30369-6_9
Delgado, A. J. M., Velázquez, U. C., González, J. G. B., Montes, A. C., Villarreal, S. M. L., García, L. E. V., Casas, R. M. S., & Luis, O. E. R. (2020). Evaluation of the essential oil of Citrus paradisi as an alternative treatment against Candida albicans. Open Journal of Stomatology, 10(9), 258. https://doi.org/10.4236/ojst.2020.109025
Deng, W., Liu, K., Cao, S., Sun, J., Zhong, B., & Chun, J. (2020). Chemical composition, antimicrobial, antioxidant, and antiproliferative properties of grapefruit essential oil prepared by molecular distillation. Molecules, 25(1), 217. https://doi.org/10.3390/molecules25010217
Dharmalingam, K., & Anandalakshmi, R. (2020). Functionalization of cellulose-based nanocomposite hydrogel films with zinc oxide complex and grapefruit seed extract for potential applications in treating chronic wounds. Polymer, 202, 122620. https://doi.org/10.1016/j.polymer.2020.122620
Di Majo, D., Giammanco, M., Guardia, M. L., Tripoli, E., Giammanco, S., & Finotti, E. (2005). Flavanones in Citrus fruit: Structure–antioxidant activity relationships. Food Research International, 38(10), 1161–1166. https://doi.org/10.1016/j.foodres.2005.05.001
Dosoky, N., & Setzer, W. (2018). Biological activities and safety of Citrus spp. essential oils. International Journal of Molecular Sciences, 19(7), 1966. https://doi.org/10.3390/ijms19071966
Dugrand, A., Olry, A., Duval, T., Hehn, A., Froelicher, Y., & Bourgaud, F. (2013). Coumarin and furanocoumarin quantitation in citrus peel via ultraperformance liquid chromatography coupled with mass spectrometry (UPLC-MS). Journal of Agricultural and Food Chemistry, 61(45), 10677–10684. https://doi.org/10.1021/jf402763t
Dugrand-Judek, A., Olry, A., Hehn, A., Costantino, G., Ollitrault, P., Froelicher, Y., & Bourgaud, F. (2015). The distribution of coumarins and furanocoumarins in Citrus species closely matches Citrus phylogeny and reflects the organization of biosynthetic pathways. PLOS ONE, 10(11), e0142757. https://doi.org/10.1371/journal.pone.0142757
Durmus, M. (2020). The effects of nanoemulsions based on citrus essential oils (orange, mandarin, grapefruit, and lemon) on the shelf life of rainbow trout (Oncorhynchus mykiss) fillets at 4 ± 2°C. Journal of Food Safety, 40(1), e12718. https://doi.org/10.1111/jfs.12718
El Kantar, S., Boussetta, N., Lebovka, N., Foucart, F., Rajha, H. N., Maroun, R. G., Louka, N., & Vorobiev, E. (2018). Pulsed electric field treatment of citrus fruits: Improvement of juice and polyphenols extraction. Innovative Food Science & Emerging Technologies, 46, 153–161. https://doi.org/10.1016/j.ifset.2017.09.024
Elleuch, M., Bedigian, D., Roiseux, O., Besbes, S., Blecker, C., & Attia, H. (2011). Dietary fibre and fibre-rich by-products of food processing: Characterisation, technological functionality and commercial applications: A review. Food Chemistry, 124(2), 411–421. https://doi.org/10.1016/j.foodchem.2010.06.077
Ertosun, G. B., Sarioglu, T., & Yapislar, H. (2019). The effect of D-Limonene-rich Citrus Grandis essential oil on proliferation of colon cancer cell line HCT116. Acta Physiologica, 227, 67–67.
EU regulation 1169/2011, Pub. L. No. 1169/2011, 18 (2011).
Ferhat, M., Boukhatem, M., Hazzit, M., Meklati, B., & Chemat, F. (2016). Cold pressing, hydrodistillation and microwave dry distillation of citrus essential oil from Algeria: A comparative study. Electronic Journal of Biology, S1, 30–41.
Figuerola, F., Hurtado, M. L., Estévez, A. M., Chiffelle, I., & Asenjo, F. (2005). Fibre concentrates from apple pomace and citrus peel as potential fibre sources for food enrichment. Food Chemistry, 91(3), 395–401. https://doi.org/10.1016/j.foodchem.2004.04.036
Frydoonfar, H. R., McGrath, D. R., & Spigelman, A. D. (2003). The variable effect on proliferation of a colon cancer cell line by the citrus fruit flavonoid Naringenin. Colorectal Disease, 5(2), 149–152. https://doi.org/10.1046/j.1463-1318.2003.00444.x
Fu, Y., Yang, Z., Xia, Y., Xing, Y., & Gui, X. (2019). Adsorption of ciprofloxacin pollutants in aqueous solution using modified waste grapefruit peel. Energy Sources, Part A: Recovery, Utilization, and Environmental Effects, 1–10. https://doi.org/10.1080/15567036.2019.1624877
Furusawa, M., Hashimoto, T., Noma, Y., & Asakawa, Y. (2005). Highly efficient production of nootkatone, the grapefruit aroma from valencene, by biotransformation. Chemical and Pharmaceutical Bulletin, 53(11), 1513–1514. https://doi.org/10.1248/cpb.53.1513
Gamboa-Gómez, C., Salgado, L. M., González-Gallardo, A., Ramos-Gómez, M., Loarca-Piña, G., & Reynoso-Camacho, R. (2014). Consumption of Ocimum sanctum L. and Citrus paradisi infusions modulates lipid metabolism and insulin resistance in obese rats. Food & Function, 5, 927–935. https://doi.org/10.1039/c3fo60604j
Gan, J., Huang, Z., Yu, Q., Peng, G., Chen, Y., Xie, J., Nie, S., & Xie, M. (2020a). Microwave assisted extraction with three modifications on structural and functional properties of soluble dietary fibers from grapefruit peel. Food Hydrocolloids, 101, 105549. https://doi.org/10.1016/j.foodhyd.2019.105549
Gan, J., Peng, G., Liu, S., Hu, X., Wang, X., Guo, S., Xie, J., Chen, Y., & Yu, Q. (2020b). Comparison of structural, functional and in vitro digestion properties of bread incorporated with grapefruit peel soluble dietary fibers prepared by three microwave-assisted modifications. Food & Function, 11(7), 6458–6466. https://doi.org/10.1039/D0FO00760A
Ganzera, M., Aberham, A., & Stuppner, H. (2006). Development and validation of an HPLC/UV/MS method for simultaneous determination of 18 preservatives in grapefruit seed extract. Journal of Agricultural and Food Chemistry, 54(11), 3768–3772. https://doi.org/10.1021/jf060543d
Garcia-Castello, E. M., Rodriguez-Lopez, A. D., Mayor, L., Ballesteros, R., Conidi, C., & Cassano, A. (2015). Optimization of conventional and ultrasound assisted extraction of flavonoids from grapefruit (Citrus paradisi L.) solid wastes. LWT – Food Science and Technology, 64(2), 1114–1122. https://doi.org/10.1016/j.lwt.2015.07.024
Girennavar, B., Cepeda, M. L., Soni, K. A., Vikram, A., Jesudhasan, P., Jayaprakasha, G., Pillai, S. D., & Patil, B. S. (2008). Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria. International Journal of Food Microbiology, 125(2), 204–208. https://doi.org/10.1016/j.ijfoodmicro.2008.03.028
Goliomytis, M., Kartsonas, N., Charismiadou, M. A., Symeon, G. K., Simitzis, P. E., & Deligeorgis, S. G. (2015). The influence of naringin or hesperidin dietary supplementation on broiler meat quality and oxidative stability. PLoS One, 10(10), 1–11. https://doi.org/10.1371/journal.pone.0141652
Gollavilli, H., Hegde, A. R., Managuli, R. S., Bhaskar, K. V., Dengale, S. J., Reddy, M. S., Kalthur, G., & Mutalik, S. (2020). Naringin nano-ethosomal novel sunscreen creams: Development and performance evaluation. Colloids and Surfaces B: Biointerfaces, 193, 111122. https://doi.org/10.1016/j.colsurfb.2020.111122
Goulas, V., & Manganaris, G. A. (2012). Exploring the phytochemical content and the antioxidant potential of Citrus fruits grown in Cyprus. Food Chemistry, 131(1), 39–47. https://doi.org/10.1016/j.foodchem.2011.08.007
Gualdani, R., Cavalluzzi, M. M., Lentini, G., & Habtemariam, S. (2016). The chemistry and pharmacology of citrus limonoids. Molecules, 21(11), 1530. https://doi.org/10.3390/molecules21111530
Guerrero, C. C., Carrasco de Brito, J., Lapa, N., & Oliveira, J. F. S. (1995). Re-use of industrial orange wastes as organic fertilizers. Bioresource Technology, 53(1), 43–51. https://doi.org/10.1016/0960-8524(95)00050-O
Gul, K., Tak, A., Singh, A. K., Singh, P., Yousuf, B., & Wani, A. A. (2015). Chemistry, encapsulation, and health benefits of β-carotene—A review. Food Science and Technology, 1, 1018696. https://doi.org/10.1080/23311932.2015.1018696
Gumushan Aktas, H., & Akgun, T. (2018). Naringenin inhibits prostate cancer metastasis by blocking voltage-gated sodium channels. Biomedicine & Pharmacotherapy, 106, 770–775. https://doi.org/10.1016/j.biopha.2018.07.008
Gunasekera, R. S., Sewgobind, K., Desai, S., Dunn, L., Black, H. S., McKeehan, W. L., & Patil, B. (2007). Lycopene and Lutein inhibit proliferation in rat prostate carcinoma cells. Nutrition and Cancer, 58(2), 171–177. https://doi.org/10.1080/01635580701328339
Ha, S. K., Park, H.-Y., Eom, H., Kim, Y., & Choi, I. (2012). Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MAPKs activation. Food and Chemical Toxicology, 50(10), 3498–3504. https://doi.org/10.1016/j.fct.2012.07.007
Hafidh, R. R., Hussein, S. Z., MalAllah, M. Q., Abdulamir, A. S., & Abu Bakar, F. (2018). A High-throughput quantitative expression analysis of cancer-related genes in human HepG2 cells in response to Limonene, a potential anti-cancer agent. Current Cancer Drug Targets, 18(8), 807–815. https://doi.org/10.2174/1568009617666171114144236
Hassan, M. A. M., & Ali, H. M. (2014). Physico-chemical properties and sensory evaluation of toast bread fortified with different levels of white grapefruit (Citrus paradise L.) albedo layer flour. World Journal of Dairy and Food Sciences, 9(2), 228–234.
Heggers, J. P., Cottingham, J., Gusman, J., Reagor, L., McCoy, L., Carino, E., Cox, R., & Zhao, J.-G. (2002). The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and In Vitro toxicity. The Journal of Alternative and Complementary Medicine, 8(3), 333–340. https://doi.org/10.1089/10755530260128023
Heo, H. J., Kim, D.-O., Shin, S. C., Kim, M. J., Kim, B. G., & Shin, D.-H. (2004). Effect of antioxidant flavanone, naringenin, from Citrus junos on neuroprotection. Journal of Agricultural and Food Chemistry, 52(6), 1520–1525. https://doi.org/10.1021/jf035079g
Hozumi, H., Hasegawa, S., Tsunenari, T., Sanpei, N., Arashina, Y., Takahashi, K., Konnno, A., Chida, E., & Tomimatsu, S. (2017). Aromatherapies using Osmanthus fragrans oil and Grapefruit oil are effective complementary treatments for anxious patients undergoing colonoscopy: A randomized controlled study. Complementary Therapies in Medicine, 34, 165–169. https://doi.org/10.1016/j.ctim.2017.08.012
Hu, J.-N., Zheng, H., Chen, X.-X., Li, X., Xu, Y., & Xu, M.-F. (2020). Synergetic effects of whey protein isolate and naringin on physical and oxidative stability of oil-in-water emulsions. Food Hydrocolloids, 101, 105517. https://doi.org/10.1016/j.foodhyd.2019.105517
Hung, W.-L., Suh, J. H., & Wang, Y. (2017). Chemistry and health effects of furanocoumarins in grapefruit. Journal of Food and Drug Analysis, 25(1), 71–83. https://doi.org/10.1016/j.jfda.2016.11.008
Ibáñez, M. D., Sanchez-Ballester, N. M., & Blázquez, M. A. (2020). Encapsulated limonene: A pleasant lemon-like aroma with promising application in the agri-food industry. A review. Molecules, 25(11), 2598. https://doi.org/10.3390/molecules25112598
Iturriaga, L., Olabarrieta, I., Castellan, A., Gardrat, C., & Coma, V. (2014). Active naringin-chitosan films: Impact of UV irradiation. Carbohydrate Polymers, 110, 374–381. https://doi.org/10.1016/j.carbpol.2014.03.062
Jourdan, P. S., McIntosh, C. A., & Mansell, R. L. (1985). Naringin levels in citrus tissues: II. quantitative distribution of naringin in Citrus paradisi MacFad. Plant Physiology, 77(4), 903–908. doi: 85/77/0903/06.
Kamal, G., Anwar, F., Hussain, A., Sarri, N., & Ashraf, M. (2011). Yield and chemical composition of Citrus essential oils as affected by drying pretreatment of peels. International Food Research Journal, 18(4), 1275–1282.
Karaman, E., Yılmaz, E., & Tuncel, N. B. (2017). Physicochemical, microstructural and functional characterization of dietary fibers extracted from lemon, orange and grapefruit seeds press meals. Bioactive Carbohydrates and Dietary Fibre, 11, 9–17. https://doi.org/10.1016/j.bcdf.2017.06.001
Karioti, A., Skaltsa, H., & Gbolade, A. A. (2007). Constituents of the distilled essential oils of Citrus reticulata and C. paradisi from Nigeria. Journal of Essential Oil Research, 19(6), 520–522. https://doi.org/10.1080/10412905.2007.9699320
Kawai, E., Takeda, R., Ota, A., Morita, E., Imai, D., Suzuki, Y., Yokoyama, H., Ueda, S., Nakahara, H., Miyamoto, T., & Okazaki, K. (2020). Increase in diastolic blood pressure induced by fragrance inhalation of grapefruit essential oil is positively correlated with muscle sympathetic nerve activity. The Journal of Physiological Sciences, 70(1), 2. https://doi.org/10.1186/s12576-020-00733-6
Kelebek, H. (2010). Sugars, organic acids, phenolic compositions and antioxidant activity of Grapefruit (Citrus paradisi) cultivars grown in Turkey. Industrial Crops and Products, 32(3), 269–274. https://doi.org/10.1016/j.indcrop.2010.04.023
Khalil, M. N. A., Farghal, H. H., & Farag, M. A. (2020). Outgoing and potential trends of composition, health benefits, juice production and waste management of the multi-faceted Grapefruit Citrus Χ paradisi: A comprehensive review for maximizing its value. Critical Reviews in Food Science and Nutrition, 1–22. https://doi.org/10.1080/10408398.2020.1830364
Khan, A., Butt, M., Randhawa, M., Karim, R., Sultan, M., & Ahmed, W. (2014). Extraction and characterization of pectin from grapefruit (Duncan cultivar) and its utilization as gelling agent. International Food Research Journal, 21(6), 2195–2199.
Kirbaşlar, F. G., Tavman, A., Dülger, B., & Türker, G. (2009). Antimicrobial activity of Turkish citrus peel oils. Pakistan Journal of Botany, 41(6), 3207–3212.
Kirbaşlar, Ş. I., Boz, I., & Kirbaşlar, F. G. (2006). Composition of Turkish Lemon and grapefruit peel oils. Journal of Essential Oil Research, 18(5), 525–543. https://doi.org/10.1080/10412905.2006.9699161
Kočevar Glavač, N., & Lunder, M. (2018). Preservative efficacy of selected antimicrobials of natural origin in a cosmetic emulsion. International Journal of Cosmetic Science, 40(3), 276–284. https://doi.org/10.1111/ics.12461
Kohajdová, Z., Karovičová, J., & Jurasová, M. (2013). Influence of grapefruit dietary fibre rich powder on the rheological characteristics of wheat flour dough and on biscuit quality. Acta Alimentaria, 42(1), 91–101. https://doi.org/10.1556/AAlim.42.2013.1.9
Koshali, Z. S., Ghotbi, M., & Nasiriyah, L. R. (2019). Study of the effect of flour replacement with grapefruit fibers on the chemistry and sensory properties of muffins. Journal of Innovation in Food Science and Technology, 11(4), 37–49.
Kreidl, M. (2020). Determination of phototoxic furanocoumarins in natural cosmetics using SPE with LC-MS. Analytica Chimica Acta, 1101, 211–221. https://doi.org/10.1016/j.aca.2019.12.015
Kritchevsky, D., & Chen, S. C. (2005). Phytosterols—Health benefits and potential concerns: A review. Nutrition Research, 25(5), 413–428. https://doi.org/10.1016/j.nutres.2005.02.003
Lado, J., Cronje, P., Alquézar, B., Page, A., Manzi, M., Gómez-Cadenas, A., Stead, A. D., Zacarías, L., & Rodrigo, M. J. (2015). Fruit shading enhances peel color, carotenes accumulation and chromoplast differentiation in red grapefruit. Physiologia Plantarum, 154(4), 469–484. https://doi.org/10.1111/ppl.12332
Langeswaran, K., Jagadeesan, A. J., Revathy, R., & Balasubramanian, M. P. (2012). Chemotherapeutic efficacy of limonin against Aflatoxin B1 induced primary hepatocarcinogenesis in Wistar albino rats. Biomedicine & Aging Pathology, 2(4), 206–211. https://doi.org/10.1016/j.biomag.2012.08.002
Larrauri, J. A., Rupérez, P., Borroto, B., & Saura-Calixto, F. (1997). Seasonal changes in the composition and properties of a high dietary fibre powder from grapefruit peel. Journal of the Science of Food and Agriculture, 74(3), 308–312.
Lavrador, P., Gaspar, V. M., & Mano, J. F. (2018). Bioinspired bone therapies using naringin: Applications and advances. Drug Discovery Today, 23(6), 1293–1304. https://doi.org/10.1016/j.drudis.2018.05.012
Lee, S. G., Kim, K., Vance, T. M., Perkins, C., Provatas, A., Wu, S., Qureshi, A., Cho, E., & Chun, O. K. (2016). Development of a comprehensive analytical method for furanocoumarins in grapefruit and their metabolites in plasma and urine using UPLC-MS/MS: A preliminary study. International Journal of Food Sciences and Nutrition, 67(8), 881–887. https://doi.org/10.1080/09637486.2016.1207157
Lei, L., Huang, B., Liu, A., Lu, Y.-J., Zhou, J.-L., Zhang, J., & Wong, W.-L. (2018). Enzymatic production of natural sweetener trilobatin from citrus flavanone naringin using immobilised α-l-rhamnosidase as the catalyst. International Journal of Food Science & Technology, 53(9), 2097–2103. https://doi.org/10.1111/ijfs.13796
Lim, J. Y., Lee, C. L., Kim, G. H., Bang, Y. J., Rhim, J. W., & Yoon, K. S. (2020). Using lactic acid bacteria and packaging with grapefruit seed extract for controlling Listeria monocytogenes growth in fresh soft cheese. Journal of Dairy Science, 103(10), 8761–8770. https://doi.org/10.3168/jds.2020-18349
Liu, S., Zhang, S., Lv, X., Lu, J., Ren, C., Zeng, Z., Zheng, L., Zhou, X., Fu, H., Zhou, D., & Chen, Y. (2019). Limonin ameliorates ulcerative colitis by regulating STAT3/miR-214 signaling pathway. International Immunopharmacology, 75, 105768. https://doi.org/10.1016/j.intimp.2019.105768
Liu, X., Wan, Y., Liu, P., Fu, Y., & Zou, W. (2018). A novel activated carbon prepared from grapefruit peel and its application in removal of phenolic compounds. Water Science and Technology, 77(10), 2517–2527. https://doi.org/10.2166/wst.2018.212
López-Marcos, M. C., Bailina, C., Viuda-Martos, M., Pérez-Alvarez, J. A., & Fernández-López, J. (2015). Effects of various fibre-rich extracts on cholesterol binding capacity during in vitro digestion of pork patties. Food and Function, 6(11), 3473–3478. https://doi.org/10.1039/C5FO00709G
López-Santiz, S. G., Torrescano-Urrutia, G. R., Vargas-Sánchez, R. D., Zavala-Cárdenas, L., & Sánchez-Escalante, A. (2017). Use of albedo and flavedo grapefruit powders as oxidative stabilisers of pork patties during chilled storage. In D. Troy, C. McDonnell, L. Hinds, & J. Kerry (Eds.), 63rd International Congress of Meat Science and Technology. Wageningen Academic Publishers.
Lu, X., Zhan, L., Feng, B., Lin, S., & Xie, J. (2006). Inhibition mechanism of growth of human pancreatic cancer by D-Limonene. Acta Pharmacologica Sinica, 27, 352–353.
Lu, X.-G., Zhan, L.-B., Feng, B.-A., Qu, M.-Y., Yu, L.-H., & Xie, J.-H. (2004). Inhibition of growth and metastasis of human gastric cancer implanted in nude mice by D-Limonene. World Journal of Gastroenterology, 10(14), 2140–2144. https://doi.org/10.3748/wjg.v10.i14.2140
Lucera, A., Mastromatteo, M., Sinigaglia, M., & Corbo, M. R. (2009). Combined effects of thymol, carvacrol and grapefruit seed extract on lipid oxidation and colour stability of poultry meat preparations. International Journal of Food Science & Technology, 44(11), 2256–2267. https://doi.org/10.1111/j.1365-2621.2009.02067.x
Ma, Y., Ye, X., Hao, Y., Xu, G., Xu, G., & Liu, D. (2008). Ultrasound-assisted extraction of hesperidin from Penggan (Citrus reticulata) peel. Ultrasonics Sonochemistry, 15(3), 227–232. https://doi.org/10.1016/j.ultsonch.2007.03.006
MacLeod, W. D., & Buigues, N. M. (1964). Sesquiterpenes. I. Nootkatone, a new grapefruit flavor constituent. Journal of Food Science, 29(5), 565–568. https://doi.org/10.1111/j.1365-2621.1964.tb00411.x
Mahato, N., Sinha, M., Sharma, K., Koteswararao, R., & Cho, M. H. (2019). Modern extraction and purification techniques for obtaining high purity food-grade bioactive compounds and value-added co-products from citrus wastes. Foods, 8(11), 523. https://doi.org/10.3390/foods8110523
Mahmoodi-Eshkaftaki, M., & Rahmanian-Koushkaki, H. (2020). An optimum strategy for substrate mixture and pretreatment in biogas plants: Potential application for high-pH waste management. Waste Management, 113, 329–341. https://doi.org/10.1016/j.wasman.2020.06.014
Mandadi, K. K., Jayaprakasha, G. K., Bhat, N. G., & Patil, B. S. (2007). Red Mexican grapefruit: A novel source for bioactive limonoids and their antioxidant activity. Zeitschrift Für Naturforschung C, 62(3–4), 179–188. https://doi.org/10.1515/znc-2007-3-405
Maqbool, M. A., Aslam, M., Akbar, W., & Iqbal, Z. (2018). Biological importance of vitamins for human health: A review. Journal of Agriculture and Basic Science, 2.
Martínez-Ballesta, M. C., Dominguez-Perles, R., Moreno, D. A., Muries, B., Alcaraz-López, C., Bastías, E., García-Viguera, C., & Carvajal, M. (2010). Minerals in plant food: Effect of agricultural practices and role in human health. A review. Agronomy for Sustainable Development, 30(2), 295–309. https://doi.org/10.1051/agro/2009022
Matthaus, B., & Özcan, M. M. (2012). Chemical evaluation of citrus seeds, an agro-industrial waste, as a new potential source of vegetable oils. Grasas y Aceites, 63(3), 313–320. https://doi.org/10.3989/gya.118411
Maxwell, E. G., Colquhoun, I. J., Chau, H. K., Hotchkiss, A. T., Waldron, K. W., Morris, V. J., & Belshaw, N. J. (2015). Rhamnogalacturonan I containing homogalacturonan inhibits colon cancer cell proliferation by decreasing ICAM1 expression. Carbohydrate Polymers, 132, 546–553. https://doi.org/10.1016/j.carbpol.2015.06.082
Meléndez-Martínez, A. J. (2018). The colourless carotenoids phytoene and phytofluene—From dietary sources to their usefulness for the functional foods and nutricosmetics industries. Journal of Food Composition and Analysis, 67, 91–103.
Merouani, S., Hamdaoui, O., Rezgui, Y., & Guemini, M. (2014). Theoretical estimation of the temperature and pressure within collapsing acoustical bubbles. Ultrasonics Sonochemistry, 21(1), 53–59. https://doi.org/10.1016/j.ultsonch.2013.05.008
Monday Kayode, R., Ephraim Edem, V., Julius Ogundun, N., Olaitan Ajibola, R., & Idowu Kayode, B. (2020). Effects of inclusion of processed Grapefruit pulp on wheat flour biscuit. Journal of Food Technology Research, 7(1), 69–77. https://doi.org/10.18488/journal.58.2020.71.69.77
Moravvej, G., & Abbar, S. (2008). Fumigant toxicity of Citrus oils against Cowpea Seed Bettle Callosobruchus maculatus (F.) (Coleoptera: Bruchidae). Pakistan Journal of Biological Sciences, 11(1), 48–54.
Mori, M., Ikeda, N., Kato, Y., Minamino, M., & Watabe, K. (2002). Inhibition of elastase activity by essential oils in vitro. Journal of Cosmetic Dermatology, 1(4), 183–187. https://doi.org/10.1111/j.1473-2165.2002.00059.x
Mozos, I., Stoian, D., Caraba, A., Malainer, C., Horbańczuk, J. O., & Atanasov, A. G. (2018). Lycopene and vascular health. Frontiers in Pharmacology, 9, 521. https://doi.org/10.3389/fphar.2018.00521
MS, U., Ferdosh, S., Haque Akanda, M. J., Ghafoor, K., AH, R., Ali, M. E., Kamaruzzaman, B. Y., MB, F., Shaarani, S., & Islam Sarker, M. Z. (2018). Techniques for the extraction of phytosterols and their benefits in human health: A review. Separation Science and Technology, 53(14), 2206–2223. https://doi.org/10.1080/01496395.2018.1454472
Müller, L., Caris-Veyrat, C., Lowe, G., & Böhm, V. (2016). Lycopene and its antioxidant role in the prevention of cardiovascular diseases—A critical review. Critical Reviews in Food Science and Nutrition, 56(11), 1868–1879. https://doi.org/10.1080/10408398.2013.801827
Murunga, A. N., Miruka, D. O., Driver, C., Nkomo, F. S., Cobongela, S. Z. Z., & Owira, P. M. O. (2016). Grapefruit derived flavonoid naringin improves ketoacidosis and lipid peroxidation in Type 1 diabetes rat model. PLOS ONE, 11(4), e0153241. https://doi.org/10.1371/journal.pone.0153241
Nagai, K., Niijima, A., Horii, Y., Shen, J., & Tanida, M. (2014). Olfactory stimulatory with grapefruit and lavender oils change autonomic nerve activity and physiological function. Autonomic Neuroscience, 185, 29–35. https://doi.org/10.1016/j.autneu.2014.06.005
Negi, P. S., & Jayaprakasha, G. (2001). Antibacterial activity of grapefruit (Citrus paradisi) peel extracts. European Food Research and Technology, 213(6), 484–487. https://doi.org/10.1007/s002170100394
Ng, I.-S., Wu, X., Lu, Y., & Yao, C. (2014). Trichoderma reesei cellulase complex in hydrolysis of agricultural waste of grapefruit peel and orange peel. BioResources, 9(4), 6420–6431. https://doi.org/10.15376/biores.9.4.6420-6431
Nishad, J., Dutta, A., Saha, S., Rudra, S. G., Varghese, E., Sharma, R. R., Tomar, M., Kumar, M., & Kaur, C. (2021). Ultrasound-assisted development of stable grapefruit peel polyphenolic nano-emulsion: Optimization and application in improving oxidative stability of mustard oil. Food Chemistry, 334, 127561. https://doi.org/10.1016/j.foodchem.2020.127561
Njoroge, S. M., Koaze, H., Karanja, P. N., & Sawamura, M. (2005). Volatile constituents of Redblush Grapefruit (Citrus paradisi) and Pummelo (Citrus grandis) peel essential oils from Kenya. Journal of Agricultural and Food Chemistry, 53(25), 9790–9794. https://doi.org/10.1021/jf051373s
Nogata, Y., Sakamoto, K., Shiratsuchi, H., Ishii, T., Yano, M., & Ohta, H. (2006). Flavonoid composition of fruit tissues of citrus species. Bioscience, Biotechnology, and Biochemistry, 70(1), 178–192. https://doi.org/10.1271/bbb.70.178
Nour el Houda, A. K. (2020). Chemical composition, antimicrobial and insecticidal activities of Citrus paradisi peel essential oil from Algeria. Journal of Microbiology, Biotechnology and Food Sciences, 9(6), 1093–1098. https://doi.org/10.15414/jmbfs.2020.9.6.1093-1098
Okunowo, W. O., Afolabi, L. O., Oyedejia, A. O., Matanmi, E., & Awodele, O. (2016). Larvicidal activity of essential oil from Citrus sinensis and Citrus paradisi against Anopheles gambiae. Biokemistri, 28(1), 16–23.
Okunowo, W. O., Oyedeji, O., Afolabi, L. O., & Matanmi, E. (2013). Essential oil of grape fruit citrus paradisi peels and its antimicrobial activities. American Journal of Plant Sciences, 04(07), 1–9. https://doi.org/10.4236/ajps.2013.47A2001
Omar, J., Alonso, I., Garaikoetxea, A., & Etxebarria, N. (2013). Optimization of Focused Ultrasound Extraction (FUSE) and Supercritical Fluid Extraction (SFE) of citrus peel volatile oils and antioxidants. Food Analytical Methods, 6(4), 1244–1252. https://doi.org/10.1007/s12161-012-9536-x
Opdyke, D. L. J. (1974). Monographs on fragrance raw materials: Grapefruit oil expressed. Food and Cosmetics Toxicology, 12(5), 723–724. https://doi.org/10.1016/0015-6264(74)90252-1
Ortuno, A., Garcia-Puig, D., Fuster, M. D., Perez, M. L., Sabater, F., Porras, I., Garcia-Lidon, A., & Del Rio, J. A. (1995). Flavanone and Nootkatone levels in different varieties of Grapefruit and Pummelo. Journal of Agricultural and Food Chemistry, 43(1), 1–5. https://doi.org/10.1021/jf00049a001
Ou, M.-C., Liu, Y.-H., Sun, Y.-W., & Chan, C.-F. (2015). The Composition, antioxidant and antibacterial activities of cold-pressed and distilled essential oils of Citrus paradisi and Citrus grandis (L.) Osbeck. Journal of Evidence-Based Complementary and Alternative Medicine, 2015, 1–9. https://doi.org/10.1155/2015/804091
Oyelami, O., Agbakwuru, E., Adeyemi, L., & Adedeji, G. (2005). The effectiveness of grapefruit (Citrus paradisi) seeds in treating urinary tract infections. Journal of Alternative & Complementary Medicine, 11(2), 369–371.
Ozaki, Y., Fong, C. H., Herman, Z., Maeda, H., Miyake, M., Ifuku, Y., & Hasegawa, S. (1991). Limonoid glucosides in citrus seeds. Agricultural and Biological Chemistry, 55(1), 137–141. https://doi.org/10.1080/00021369.1991.10870551
Özogul, Y., Özogul, F., & Kulawik, P. (2021). The antimicrobial effect of grapefruit peel essential oil and its nanoemulsion on fish spoilage bacteria and food-borne pathogens. LWT, 136, 110362. https://doi.org/10.1016/j.lwt.2020.110362
Palazzolo, E., Armando Laudicina, V., & Antonietta Germanà, M. (2013). Current and potential use of citrus essential oils. Current Organic Chemistry, 17(24), 3042–3049. https://doi.org/10.2174/13852728113179990122
Park, H.-J., Jung, U. J., Cho, S.-J., Jung, H.-K., Shim, S., & Choi, M.-S. (2013). Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipid-regulating enzymes in db/db mice. The Journal of Nutritional Biochemistry, 24(2), 419–427. https://doi.org/10.1016/j.jnutbio.2011.12.009
Park, J.-H., Lee, M., & Park, E. (2014). Antioxidant activity of Orange flesh and peel extracted with various solvents. Preventive Nutrition and Food Science, 19(4), 291–298. https://doi.org/10.3746/pnf.2014.19.4.291
Patsalou, M., Samanides, C. G., Protopapa, E., Stavrinou, S., Vyrides, I., & Koutinas, M. (2019). A Citrus peel waste biorefinery for ethanol and methane production. Molecules, 24(13), 2451. https://doi.org/10.3390/molecules24132451
Peleg, H., Naim, M., Rouseff, R. L., & Zehavi, U. (1991). Distribution of bound and free phenolic acids in oranges (Citrus sinensis) and grapefruits (Citrus paradisi). Journal of the Science of Food and Agriculture, 57(3), 417–426.
Perrut, M. (1999). Extraction par fluide supercritique. Extraction Par Fluide Supercritique, J2(J2770), J2770.1–J2770.12.
Pleguezuelos-Villa, M., Mir-Palomo, S., Díez-Sales, O., Buso, M. A. O. V., Sauri, A. R., & Nácher, A. (2018). A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy. Colloids and Surfaces B: Biointerfaces, 162, 265–270. https://doi.org/10.1016/j.colsurfb.2017.11.068
Putnik, P., Bursać Kovačević, D., Režek Jambrak, A., Barba, F. J., Cravotto, G., Binello, A., Lorenzo, J. M., & Shpigelman, A. (2017). Innovative “Green” and novel strategies for the extraction of bioactive added value compounds from citrus wastes—A review. Molecules, 22(5), 680. https://doi.org/10.3390/molecules22050680
Rae, J., Ashokkumar, M., Eulaerts, O., von Sonntag, C., Reisse, J., & Grieser, F. (2005). Estimation of ultrasound induced cavitation bubble temperatures in aqueous solutions. Ultrasonics Sonochemistry, 12(5), 325–329.
Rajadurai, M., & Stanely Mainzen Prince, P. (2007). Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. Toxicology, 230(2–3), 178–188. https://doi.org/10.1016/j.tox.2006.11.053
Ravichandran, C., Badgujar, P. C., Gundev, P., & Upadhyay, A. (2018). Review of toxicological assessment of D-limonene, a food and cosmetics additive. Food and Chemical Toxicology, 120, 668–680. https://doi.org/10.1016/j.fct.2018.07.052
Raviv, M., Medina, S., & Shamir, Y. (1999). Cocomposting – A Method to improve results of poultry manure composting. Compost Science & Utilization, 7(2), 70–73. https://doi.org/10.1080/1065657X.1999.10701966
Reagor, L., Gusman, J., McCoy, L., Carino, E., & Heggers, J. P. (2002). The effectiveness of processed grapefruit-seed extract as an antibacterial agent: I. An In Vitro agar assay. The Journal of Alternative and Complementary Medicine, 8(3), 325–332. https://doi.org/10.1089/10755530260128014
Romero-Cano, L. A., González-Gutiérrez, L. V., Baldenegro-Pérez, L. A., & Carrasco-Marín, F. (2017). Grapefruit peels as biosorbent: Characterization and use in batch and fixed bed column for Cu(II) uptake from wastewater: Grapefruit peels as biosorbent: Characterization and use for Cu(II) removal. Journal of Chemical Technology & Biotechnology, 92(7), 1650–1658. https://doi.org/10.1002/jctb.5161
Rosales, E., Meijide, J., Tavares, T., Pazos, M., & Sanromán, M. A. (2016). Grapefruit peelings as a promising biosorbent for the removal of leather dyes and hexavalent chromium. Process Safety and Environmental Protection, 101, 61–71. https://doi.org/10.1016/j.psep.2016.03.006
Routray, W., & Orsat, V. (2019). Microwave assisted extraction of flavonoids: A comprehensive overview. In Reference module in food science. Elsevier. https://doi.org/10.1016/B978-0-08-100596-5.21108-6
Saini, R. K., Nile, S. H., & Park, S. W. (2015). Carotenoids from fruits and vegetables: Chemistry, analysis, occurrence, bioavailability and biological activities. Food Research International, 76(3), 735–750. https://doi.org/10.1016/j.foodres.2015.07.047
Salehi, B., Fokou, P., Sharifi-Rad, M., Zucca, P., Pezzani, R., Martins, N., & Sharifi-Rad, J. (2019). The therapeutic potential of naringenin: A review of clinical trials. Pharmaceuticals, 12(1), 11. https://doi.org/10.3390/ph12010011
Schiewer, S., & Patil, S. B. (2008). Pectin-rich fruit wastes as biosorbents for heavy metal removal: Equilibrium and kinetics. Bioresource Technology, 99(6), 1896–1903. https://doi.org/10.1016/j.biortech.2007.03.060
Seden, K., Dickinson, L., Khoo, S., & Back, D. (2010). Grapefruit-drug interactions. Drugs, 70(18), 2373–2407. https://doi.org/10.2165/11585250-000000000-00000
Sekhar, K. C., Rajanikanth, A., Bobby, M. N., & Kanala, J. R. (2018). A review on anticancer potential of natural drugs: Hispolon and limonene. International Journal of Current Microbiology and Applied Sciences, 7(11), 3253–3263. https://doi.org/10.20546/ijcmas.2018.711.375
Seleim, M., Hassan, M. A., & Saleh, A. (2019). Physico-chemical evaluation of white and pink grapefruit (Citrus paradisi) juice. Assiut Journal of Agricultural Sciences, 50(3), 112–122.
Semerciöz, A. S., Göğüş, F., Çelekli, A., & Bozkurt, H. (2017). Development of carbonaceous material from grapefruit peel with microwave implemented-low temperature hydrothermal carbonization technique for the adsorption of Cu (II). Journal of Cleaner Production, 165, 599–610. https://doi.org/10.1016/j.jclepro.2017.07.159
Shan, Y. (2016). Functional components of citrus peel. In Comprehensive utilization of citrus by-products (pp. 1–13). Elsevier. https://doi.org/10.1016/B978-0-12-809785-4.00001-0
Shankar, S., & Rhim, J.-W. (2018a). Preparation of antibacterial poly(lactide)/poly(butylene adipate-co-terephthalate) composite films incorporated with grapefruit seed extract. International Journal of Biological Macromolecules, 7.
Shankar, S., & Rhim, J.-W. (2018b). Antimicrobial wrapping paper coated with a ternary blend of carbohydrates (alginate, carboxymethyl cellulose, carrageenan) and grapefruit seed extract. Carbohydrate Polymers, 196, 92–101. https://doi.org/10.1016/j.carbpol.2018.04.128
Shaw, P. E., & Wilson, C. W. (1981). Importance of nootkatone to the aroma of grapefruit oil and the flavor of grapefruit juice. Journal of Agricultural and Food Chemistry, 29(3), 677–679. https://doi.org/10.1021/jf00105a063
Shen, J., Niijima, A., Tanida, M., Horii, Y., Maeda, K., & Nagai, K. (2005). Olfactory stimulation with scent of grapefruit oil affects autonomic nerves, lipolysis and appetite in rats. Neuroscience Letters, 380(3), 289–294. https://doi.org/10.1016/j.neulet.2005.01.058
Shin, Y. J., Song, H. Y., Seo, Y. B., & Song, K. B. (2012). Preparation of red algae film containing grapefruit seed extract and application for the packaging of cheese and bacon. Food Science and Biotechnology, 21(1), 225–231. https://doi.org/10.1007/s10068-012-0029-x
Siles, J. A., Vargas, F., Gutiérrez, M. C., Chica, A. F., & Martín, M. A. (2016). Integral valorisation of waste orange peel using combustion, biomethanisation and co-composting technologies. Bioresource Technology, 211, 173–182. https://doi.org/10.1016/j.biortech.2016.03.056
Siles López, J. Á., Li, Q., & Thompson, I. P. (2010). Biorefinery of waste orange peel. Critical Reviews in Biotechnology, 30(1), 63–69. https://doi.org/10.3109/07388550903425201
Sir Elkhatim, K. A., Elagib, R. A. A., & Hassan, A. B. (2018). Content of phenolic compounds and vitamin C and antioxidant activity in wasted parts of Sudanese citrus fruits. Food Science and Nutrition, 6(5), 1214–1219. https://doi.org/10.1002/fsn3.660
Sommer, A. (2001). Vitamin A deficiency. In ELS. American Cancer Society. https://doi.org/10.1038/npg.els.0002106
Sumorek-Wiadro, J., Zając, A., Maciejczyk, A., & Jakubowicz-Gil, J. (2020). Furanocoumarins in anticancer therapy – For and against. Fitoterapia, 142, 104492. https://doi.org/10.1016/j.fitote.2020.104492
Takeoka, G., Dao, L., Wong, R. Y., Lundin, R., & Mahoney, N. (2001). Identification of Benzethonium Chloride in Commercial Grapefruit Seed Extracts. Journal of Agricultural and Food Chemistry, 49(7), 3316–3320. https://doi.org/10.1021/jf010222w
Tan, Y. M., Lim, S. H., Tay, B. Y., Lee, M. W., & Thian, E. S. (2015). Functional chitosan-based grapefruit seed extract composite films for applications in food packaging technology. Materials Research Bulletin, 69, 142–146. https://doi.org/10.1016/j.materresbull.2014.11.041
Teixeira, B., Marques, A., Ramos, C., Neng, N. R., Nogueira, J. M. F., Saraiva, J. A., & Nunes, M. L. (2013). Chemical composition and antibacterial and antioxidant properties of commercial essential oils. Industrial Crops and Products, 43, 587–595. https://doi.org/10.1016/j.indcrop.2012.07.069
Torab-Mostaedi, M., Asadollahzadeh, M., Hemmati, A., & Khosravi, A. (2015). Biosorption of lanthanum and cerium from aqueous solutions by grapefruit peel: Equilibrium, kinetic and thermodynamic studies. Research on Chemical Intermediates, 41(2), 559–573. https://doi.org/10.1007/s11164-013-1210-4
USDA. (2020). Citrus: World markets and trade.
Uysal, B., Sozmen, F., Aktas, O., Oksal, B. S., & Kose, E. O. (2011). Essential oil composition and antibacterial activity of the grapefruit (Citrus Paradisi. L) peel essential oils obtained by solvent-free microwave extraction: Comparison with hydrodistillation. International Journal of Food Science and Technology, 46(7), 1455–1461. https://doi.org/10.1111/j.1365-2621.2011.02640.x
van Breemen, R. B., & Pajkovic, N. (2008). Multitargeted therapy of cancer by lycopene. Cancer Letters, 269(2), 339–351. https://doi.org/10.1016/j.canlet.2008.05.016
Victor, M. M., David, J. M., Sakukuma, M. C. K., França, E. L., & Nunes, A. V. J. (2018). A simple and efficient process for the extraction of naringin from grapefruit peel waste. Green Processing and Synthesis, 7(6), 524–529. https://doi.org/10.1515/gps-2017-0112
Vikram, A., Jesudhasan, P. R., Jayaprakasha, G. K., Pillai, B. S., & Patil, B. S. (2010). Grapefruit bioactive limonoids modulate E. coli O157:H7 TTSS and biofilm. International Journal of Food Microbiology, 140(2–3), 109–116. https://doi.org/10.1016/j.ijfoodmicro.2010.04.012
Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., & Pérez-Álvarez, J. (2008). Antifungal activity of lemon (Citrus lemon L.), mandarin (Citrus reticulata L.), grapefruit (Citrus paradisi L.) and orange (Citrus sinensis L.) essential oils. Food Control, 19(12), 1130–1138. https://doi.org/10.1016/j.foodcont.2007.12.003
Vo, Q. V., Nam, P. C., Thong, N. M., Trung, N. T., Phan, C.-T. D., & Mechler, A. (2019). Antioxidant motifs in flavonoids: O–H versus C–H bond dissociation. ACS Omega, 4(5), 8935–8942. https://doi.org/10.1021/acsomega.9b00677
von Woedtke, T., Schlüter, B., Pflegel, P., Lindequist, U., & Jülich, W. D. (1999). Aspects of the antimicrobial efficacy of grapefruit seed extract and its relation to preservative substances contained. Die Pharmazie, 54(6), 452–456.
Waheed, A., Mahmud, S., Saleem, M., & Ahmad, T. (2009). Fatty acid composition of neutral lipid: Classes of Citrus seed oil. Journal of Saudi Chemical Society, 13(3), 269–272. https://doi.org/10.1016/j.jscs.2009.10.007
Wang, L.-F., & Rhim, J.-W. (2016). Grapefruit seed extract incorporated antimicrobial LDPE and PLA films: Effect of type of polymer matrix. LWT, 74, 338–345. https://doi.org/10.1016/j.lwt.2016.07.066
Wang, S., Tu, H., Wan, J., Chen, W., Liu, X., Luo, J., Xu, J., & Zhang, H. (2016). Spatio-temporal distribution and natural variation of metabolites in citrus fruits. Food Chemistry, 199, 8–17. https://doi.org/10.1016/j.foodchem.2015.11.113
Wang, W., Ma, X., Xu, Y., Cao, Y., Jiang, Z., Ding, T., Ye, X., & Liu, D. (2015). Ultrasound-assisted heating extraction of pectin from grapefruit peel: Optimization and comparison with the conventional method. Food Chemistry, 178, 106–114. https://doi.org/10.1016/j.foodchem.2015.01.080
Wang, W., Wu, X., Chantapakul, T., Wang, D., Zhang, S., Ma, X., Ding, T., Ye, X., & Liu, D. (2017). Acoustic cavitation assisted extraction of pectin from waste grapefruit peels: A green two-stage approach and its general mechanism. Food Research International, 102, 101–110. https://doi.org/10.1016/j.foodres.2017.09.087
Wangensteen, H., Molden, E., Christensen, H., & Malterud, K. E. (2003). Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel. European Journal of Clinical Pharmacology, 58(10), 663–668. https://doi.org/10.1007/s00228-002-0537-3
Wei, X., Chen, C., Yu, Q., Gady, A., Yu, Y., Liang, G., & Gmitter, F. G. (2014). Novel expression patterns of carotenoid pathway-related genes in citrus leaves and maturing fruits. Tree Genetics and Genomes, 10(3), 439–448. https://doi.org/10.1007/s11295-013-0688-7
Wikandari, R., Nguyen, H., Millati, R., Niklasson, C., & Taherzadeh, M. J. (2015). Improvement of biogas production from orange peel waste by leaching of limonene. BioMed Research International, 2015, e494182. https://doi.org/10.1155/2015/494182
Wilkins, M. R., Widmer, W. W., Grohmann, K., & Cameron, R. G. (2007). Hydrolysis of grapefruit peel waste with cellulase and pectinase enzymes. Bioresource Technology, 98(8), 1596–1601. https://doi.org/10.1016/j.biortech.2006.06.022
Xi, W., Zhang, G., Jiang, D., & Zhou, Z. (2015). Phenolic compositions and antioxidant activities of grapefruit (Citrus paradisi Macfadyen) varieties cultivated in China. International Journal of Food Sciences and Nutrition, 66(8), 858–866. https://doi.org/10.3109/09637486.2015.1095864
Xu, C.-J., Fraser, P. D., Wang, W.-J., & Bramley, P. M. (2006). Differences in the carotenoid content of ordinary citrus and lycopene-accumulating mutants. Journal of Agricultural and Food Chemistry, 54(15), 5474–5481. https://doi.org/10.1021/jf060702t
Xu, W., Qu, W., Huang, K., Guo, F., Yang, J., Zhao, H., & Luo, Y. (2007). Antibacterial effect of grapefruit seed extract on food-borne pathogens and its application in the preservation of minimally processed vegetables. Postharvest Biology and Technology, 45(1), 126–133. https://doi.org/10.1016/j.postharvbio.2006.11.019
Xu, Y., Zhang, L., Bailina, Y., Ge, Z., Ding, T., Ye, X., & Liu, D. (2014). Effects of ultrasound and/or heating on the extraction of pectin from grapefruit peel. Journal of Food Engineering, 126, 72–81. https://doi.org/10.1016/j.jfoodeng.2013.11.004
Yang, S.-A., Jeon, S.-K., Lee, E.-J., Shim, C.-H., & Lee, I.-S. (2010). Comparative study of the chemical composition and antioxidant activity of six essential oils and their components. Natural Product Research, 24(2), 140–151. https://doi.org/10.1080/14786410802496598
Ye, Z., Liang, Z., Mi, Q., & Guo, Y. (2020). Limonene terpenoid obstructs human bladder cancer cell (T24 cell line) growth by inducing cellular apoptosis, caspase activation, G2/M phase cell cycle arrest and stops cancer metastasis. Journal of BUON Official Journal of the Balkan Union of Oncology, 25(1), 280–285.
Yilmaz, E., Aydeniz Guneser, B., & Ok, S. (2019). Valorization of Grapefruit seeds: Cold press oil production. Waste and Biomass Valorization, 10(9), 2713–2724. https://doi.org/10.1007/s12649-018-0286-x
Yu, J., Dandekar, D. V., Toledo, R. T., Singh, R. K., & Patil, B. S. (2007). Supercritical fluid extraction of limonoids and naringin from grapefruit (Citrus paradisi Macf.) seeds. Food Chemistry, 105(3), 1026–1031. https://doi.org/10.1016/j.foodchem.2007.04.062
Yu, X., Lin, H., Wang, Y., Lv, W., Zhang, S., Qian, Y., Deng, X., Feng, N., Yu, H., & Qian, B. (2018). D-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer. Oncotargets and Therapy, 11, 1833–1847. https://doi.org/10.2147/OTT.S155716
Zaidun, N. H., Thent, Z. C., & Latiff, A. A. (2018). Combating oxidative stress disorders with citrus flavonoid: Naringenin. Life Sciences, 208, 111–122. https://doi.org/10.1016/j.lfs.2018.07.017
Zarate Vilet, N., Gué, E., Servent, A., Delalonde, M., & Wisniewski, C. (2020). Filtration-compression step as downstream process for flavonoids extraction from citrus peels: Performances and flavonoids dispersion state in the filtrate. Food and Bioproducts Processing, 120, 104–113. https://doi.org/10.1016/j.fbp.2020.01.001
Zema, D. A., Calabrò, P. S., Folino, A., Tamburino, V., Zappia, G., & Zimbone, S. M. (2018). Valorisation of citrus processing waste: A review. Waste Management, 80, 252–273. https://doi.org/10.1016/j.wasman.2018.09.024
Zhang, J. (2007). Flavonoids in grapefruit and commercial grapefruit juices: Concentration, distribution, and potential health benefits. Proceedings of the Florida State Horticultural Society, 120, 288–294.
Zhang, W., Song, J., He, Q., Wang, H., Lyu, W., Feng, H., Xiong, W., Guo, W., Wu, J., & Chen, L. (2020). Novel pectin based composite hydrogel derived from grapefruit peel for enhanced Cu(II) removal. Journal of Hazardous Materials, 384, 121445. https://doi.org/10.1016/j.jhazmat.2019.121445
Zhang, Y., & Xu, H. (2017). Recent progress in the chemistry and biology of limonoids. RSC Advances, 7(56), 35191–35220. https://doi.org/10.1039/C7RA04715K
Zheng, H. (2016). Determination of sugars, organic acids, aroma components, and carotenoids in grapefruit pulps. Food Chemistry, 10.
Zhou, C., Lai, Y., Huang, P., Xie, L., Lin, H., Zhou, Z., Mo, C., Deng, G., Yan, W., Gao, Z., Huang, S., Chen, Y., Sun, X., Lv, Z., & Gao, L. (2019). Naringin attenuates alcoholic liver injury by reducing lipid accumulation and oxidative stress. Life Sciences, 216, 305–312. https://doi.org/10.1016/j.lfs.2018.07.031
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Zarate-Vilet, N., Gué, E., Delalonde, M., Wisniewski, C. (2022). Valorization of Grapefruit (Citrus × paradisi) Processing Wastes. In: Ramadan, M.F., Farag, M.A. (eds) Mediterranean Fruits Bio-wastes. Springer, Cham. https://doi.org/10.1007/978-3-030-84436-3_8
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