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Clinical Applications of the Food Addiction Concept

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Food Addiction, Obesity, and Disorders of Overeating
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Abstract

In this chapter, we will explore the non-dietary treatment options for food addiction (FA). There has been little research done specifically on the treatment of FA, and more work is needed. However, much can be borrowed from traditional treatments for substance use disorders (SUD) and other eating disorders (EDs). Many of the approaches may be used simultaneously and could possibly be synergistic. Potentially useful interventions include psychoeducation regarding the neurobiological underpinnings of FA, evidence-based psychosocial approaches to SUD adapted for FA, psychopharmacology, emphasis on the importance of sleep and exercise, self-help programs and other support, and treatment of underlying psychiatric comorbidities. Bariatric surgery and neuromodulation may also beneficially affect the course of FA. Finally, we will explore the concept of treatment matching in order to assist providers in determining the best course of treatment for individual patients.

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References

  1. Wilcox CE, Bogenschutz MB. Psychopharmacologies for alcohol and drug use disorders. In: McCrady BS, Epstein EE, editors. Addictions: a comprehensive guidebook. 2nd ed. New York: Oxford University Press; 2013. p. 526–50.

    Google Scholar 

  2. Center for Substance Abuse Treatment. Groups and substance abuse treatment. In: Substance abuse treatment: group therapy, Treatment improvement protocol (TIP) series, No. 41. Rockville: Substance Abuse and Mental Health Services Administration (US); 2005. Available from: https://www.ncbi.nlm.nih.gov/books/NBK64223/.

    Google Scholar 

  3. Wiss D, Brewerton T. Separating the signal from the noise: how psychiatric diagnoses can help discern food addiction from dietary restraint. Nutrients. 2020;12(10):2937.

    Article  PubMed Central  Google Scholar 

  4. Treasure J, Leslie M, Chami R, Fernandez-Aranda F. Are trans diagnostic models of eating disorders fit for purpose? A consideration of the evidence for food addiction. Eur Eat Disord Rev. 2018;26(2):83–91.

    Article  PubMed  Google Scholar 

  5. Carter A, Hardman CA, Burrows T. Food addiction and eating addiction: scientific advances and their clinical, social and policy implications. Nutrients. 2020;12(5):1485.

    Article  PubMed Central  Google Scholar 

  6. Carter A, Hendrikse J, Lee N, Yucel M, Verdejo-Garcia A, Andrews ZB, et al. The neurobiology of “food addiction” and its implications for obesity treatment and policy. Annu Rev Nutr. 2016;36:105–28.

    Article  CAS  PubMed  Google Scholar 

  7. Adams RC, Sedgmond J, Maizey L, Chambers CD, Lawrence NS. Food addiction: implications for the diagnosis and treatment of overeating. Nutrients. 2019;11(9):2086.

    Article  PubMed Central  Google Scholar 

  8. Meule A. A critical examination of the practical implications derived from the food addiction concept. Curr Obes Rep. 2019;8(1):11–7.

    Article  PubMed  PubMed Central  Google Scholar 

  9. May J, Andrade J, Kavanagh DJ, Feeney GF, Gullo MJ, Statham DJ, et al. The craving experience questionnaire: a brief, theory-based measure of consummatory desire and craving. Addiction. 2014;109(5):728–35.

    Article  PubMed  Google Scholar 

  10. Appelhans BM, French SA, Pagoto SL, Sherwood NE. Managing temptation in obesity treatment: a neurobehavioral model of intervention strategies. Appetite. 2016;96:268–79.

    Article  PubMed  Google Scholar 

  11. Meurk C, Fraser D, Weier M, Lucke J, Carter A, Hall W. Assessing the place of neurobiological explanations in accounts of a family member’s addiction. Drug Alcohol Rev. 2016;35(4):461–9.

    Article  PubMed  Google Scholar 

  12. Dackis C, O’Brien C. Neurobiology of addiction: treatment and public policy ramifications. Nat Neurosci. 2005;8(11):1431–6.

    Article  CAS  PubMed  Google Scholar 

  13. Avery JJ, Avery JD, Mouallem J, Demner AR, Cooper J. Physicians’ and attorneys’ beliefs and attitudes related to the brain disease model of addiction. Am J Addict. 2020;29(4):305–12.

    Article  PubMed  Google Scholar 

  14. Latner JD, Puhl RM, Murakami JM, O’Brien KS. Food addiction as a causal model of obesity. Effects on stigma, blame, and perceived psychopathology. Appetite. 2014;77:77–82.

    Article  PubMed  Google Scholar 

  15. Pearl RL, Lebowitz MS. Beyond personal responsibility: effects of causal attributions for overweight and obesity on weight-related beliefs, stigma, and policy support. Psychol Health. 2014;29(10):1176–91.

    Article  PubMed  Google Scholar 

  16. Sikorski C, Luppa M, Kaiser M, Glaesmer H, Schomerus G, Konig HH, et al. The stigma of obesity in the general public and its implications for public health – a systematic review. BMC Public Health. 2011;11:661.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Meadows A, Higgs S. Internalized weight stigma and the progression of food addiction over time. Body Image. 2020;34:67–71.

    Article  PubMed  Google Scholar 

  18. Puhl RM, Himmelstein MS, Pearl RL. Weight stigma as a psychosocial contributor to obesity. Am Psychol. 2020;75(2):274–89.

    Article  PubMed  Google Scholar 

  19. Lee NM, Carter A, Owen N, Hall WD. The neurobiology of overeating. Treating overweight individuals should make use of neuroscience research, but not at the expense of population approaches to diet and lifestyle. EMBO Rep. 2012;13(9):785–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Gadde KM, Atkins KD. The limits and challenges of antiobesity pharmacotherapy. Expert Opin Pharmacother. 2020;21(11):1319–28.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Fairburn CG. Overcoming binge eating, second edition: the proven program to learn why you binge and how you can stop. New York: The Guilford Press; 2013.

    Google Scholar 

  22. Lanza PV, Garcia PF, Lamelas FR, Gonzalez-Menendez A. Acceptance and commitment therapy versus cognitive behavioral therapy in the treatment of substance use disorder with incarcerated women. J Clin Psychol. 2014;70:644–57.

    Article  PubMed  Google Scholar 

  23. Rodda SN, Booth N, Brittain M, McKean J, Thornley S. I was truly addicted to sugar: a consumer-focused classification system of behaviour change strategies for sugar reduction. Appetite. 2020;144:104456.

    Article  PubMed  Google Scholar 

  24. Vidmar AP, Pretlow R, Borzutzky C, Wee CP, Fox DS, Fink C, et al. An addiction model-based mobile health weight loss intervention in adolescents with obesity. Pediatr Obes. 2019;14(2):e12464.

    Article  CAS  PubMed  Google Scholar 

  25. Pretlow RA, Stock CM, Roeger L, Allison S. Treatment of the sensory and motor components of urges to eat (eating addiction?): a mobile-health pilot study for obesity in young people. Eat Weight Disord. 2020;25(6):1779–87.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Seligman ME, Railton P, Baumeister RF, Sripada C. Navigating into the future or driven by the past. Perspect Psychol Sci. 2013;8(2):119–41.

    Article  PubMed  Google Scholar 

  27. Chao AM, Wadden TA, Tronieri JS, Pearl RL, Alamuddin N, Bakizada ZM, et al. Effects of addictive-like eating behaviors on weight loss with behavioral obesity treatment. J Behav Med. 2019;42(2):246–55.

    Article  PubMed  Google Scholar 

  28. Miller-Matero LR, Brescacin C, Clark SM, Troncone CL, Tobin ET. Why WAIT? Preliminary evaluation of the weight assistance and intervention techniques (WAIT) group. Psychol Health Med. 2019;24(9):1029–37.

    Article  PubMed  Google Scholar 

  29. Hettema JE, Hendricks PS. Motivational interviewing for smoking cessation: a meta-analytic review. J Consult Clin Psychol. 2010;78(6):868–84.

    Article  PubMed  Google Scholar 

  30. Barnes RD, Ivezaj V, Martino S, Pittman BP, Grilo CM. Back to basics? No weight loss from motivational interviewing compared to nutrition psychoeducation at one-year follow-up. Obesity. 2017;25(12):2074–8.

    Article  PubMed  Google Scholar 

  31. Burrows T, Collins R, Rollo M, Leary M, Hides L, Davis C. The feasibility of a personality targeted intervention for addictive overeating: FoodFix. Appetite. 2021;156:104974.

    Article  PubMed  Google Scholar 

  32. van Strien T, Ouwens MA. Effects of distress, alexithymia and impulsivity on eating. Eat Behav. 2007;8(2):251–7.

    Article  PubMed  Google Scholar 

  33. Ouwens MA, van Strien T, van Leeuwe JF. Possible pathways between depression, emotional and external eating. A structural equation model. Appetite. 2009;53(2):245–8.

    Article  PubMed  Google Scholar 

  34. Fauconnier M, Rousselet M, Brunault P, Thiabaud E, Lambert S, Rocher B, et al. Food addiction among female patients seeking treatment for an eating disorder: prevalence and associated factors. Nutrients. 2020;12(6):1897.

    Article  PubMed Central  Google Scholar 

  35. Janssen L, Kan CC, Carpentier PJ, Sizoo B, Hepark S, Schellekens MPJ, et al. Mindfulness-based cognitive therapy v. treatment as usual in adults with ADHD: a multicentre, single-blind, randomised controlled trial. Psychol Med. 2019;49(1):55–65.

    Article  PubMed  Google Scholar 

  36. Forrest LN, Jacobucci RC, Grilo CM. Empirically determined severity levels for binge-eating disorder outperform existing severity classification schemes. Psychol Med. 2020:1–11.

    Google Scholar 

  37. Andres A, Saldana C. Body dissatisfaction and dietary restraint influence binge eating behavior. Nutr Res. 2014;34(11):944–50.

    Article  CAS  PubMed  Google Scholar 

  38. Thompson KJ. Body image, eating disorders and obesity: an integrative guide for assessment and treatment. Washington, DC: American Psychological Association; 2000.

    Google Scholar 

  39. Pacanowski CR, Mason TB, Crosby RD, Mitchell JE, Crow SJ, Wonderlich SA, et al. Weight change over the course of binge eating disorder treatment: relationship to binge episodes and psychological factors. Obesity. 2018;26(5):838–44.

    Article  PubMed  Google Scholar 

  40. Genario R, Cipolla-Neto J, Bueno AA, Santos HO. Melatonin supplementation in the management of obesity and obesity-associated disorders: a review of physiological mechanisms and clinical applications. Pharmacol Res. 2021;163:105254.

    Article  CAS  PubMed  Google Scholar 

  41. Coulter AA, Rebello CJ, Greenway FL. Centrally acting agents for obesity: past, present, and future. Drugs. 2018;78(11):1113–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Lederman O, Ward PB, Firth J, Maloney C, Carney R, Vancampfort D, et al. Does exercise improve sleep quality in individuals with mental illness? A systematic review and meta-analysis. J Psychiatr Res. 2019;109:96–106.

    Article  PubMed  Google Scholar 

  43. van der Zweerde T, Bisdounis L, Kyle SD, Lancee J, van Straten A. Cognitive behavioral therapy for insomnia: a meta-analysis of long-term effects in controlled studies. Sleep Med Rev. 2019;48:101208.

    Article  PubMed  Google Scholar 

  44. Schuch FB, Stubbs B. The role of exercise in preventing and treating depression. Curr Sports Med Rep. 2019;18(8):299–304.

    Article  PubMed  Google Scholar 

  45. Lambez B, Harwood-Gross A, Golumbic EZ, Rassovsky Y. Non-pharmacological interventions for cognitive difficulties in ADHD: a systematic review and meta-analysis. J Psychiatr Res. 2020;120:40–55.

    Article  PubMed  Google Scholar 

  46. Robertson CL, Ishibashi K, Chudzynski J, Mooney LJ, Rawson RA, Dolezal BA, et al. Effect of exercise training on striatal dopamine D2/D3 receptors in methamphetamine users during behavioral treatment. Neuropsychopharmacology. 2016;41(6):1629–36.

    Article  CAS  PubMed  Google Scholar 

  47. Koob GF, Powell P, White A. Addiction as a coping response: hyperkatifeia, deaths of despair, and COVID-19. Am J Psychiatry. 2020;177(11):1031–7.

    Article  PubMed  Google Scholar 

  48. Wiss DA, Brewerton TD. Adverse childhood experiences and adult obesity: a systematic review of plausible mechanisms and meta-analysis of cross-sectional studies. Physiol Behav. 2020;223:112964.

    Article  CAS  PubMed  Google Scholar 

  49. Wilcox CE. Non-convulsive neurostimulation for the treatment of psychiatric disorders part I: FDA-approved treatments. American Physician Institute; 2020. Available from: CMEToGo.com.

    Google Scholar 

  50. Wilcox CE. Non-convulsive neurostimulation for the treatment of psychiatric disorders part II: emerging treatments. American Physician Institute; 2020. Available from: CMEToGo.com.

    Google Scholar 

  51. Val-Laillet D, Aarts E, Weber B, Ferrari M, Quaresima V, Stoeckel LE, et al. Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity. Neuroimage Clin. 2015;8:1–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Maizey L, Allen CP, Dervinis M, Verbruggen F, Varnava A, Kozlov M, et al. Comparative incidence rates of mild adverse effects to transcranial magnetic stimulation. Clin Neurophysiol. 2013;124(3):536–44.

    Article  PubMed  Google Scholar 

  53. Rossi S, Hallett M, Rossini PM, Pascual-Leone A, Safety of TMS Consensus Group. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol. 2009;120(12):2008–39.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Taylor R, Galvez V, Loo C. Transcranial magnetic stimulation (TMS) safety: a practical guide for psychiatrists. Australas Psychiatry. 2018;26(2):189–92.

    Article  PubMed  Google Scholar 

  55. Feil J, Zangen A. Brain stimulation in the study and treatment of addiction. Neurosci Biobehav Rev. 2010;34(4):559–74.

    Article  PubMed  Google Scholar 

  56. Hall PA, Vincent CM, Burhan AM. Non-invasive brain stimulation for food cravings, consumption, and disorders of eating: a review of methods, findings and controversies. Appetite. 2018;124:78–88.

    Article  PubMed  Google Scholar 

  57. Wilcox CE, Clifford J, Ling J, Mayer AR, Bigelow R, Bogenschutz MP, et al. Stroop-related cerebellar and temporal activation is correlated with negative affect and alcohol use disorder severity. Brain Imaging Behav. 2020;14:586–98.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Wilcox CE. Binge eating disorder. American Physician Institute; 2019. Available from: CMEtoGo.com.

    Google Scholar 

  59. Kinasz KR, Ross DA, Cooper JJ. Eat to live or live to eat? The neurobiology of appetite regulation. Biol Psychiatry. 2017;81(9):e73–e5.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Uher R, Yoganathan D, Mogg A, Eranti SV, Treasure J, Campbell IC, et al. Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving. Biol Psychiatry. 2005;58(10):840–2.

    Article  PubMed  Google Scholar 

  61. Kim SH, Chung JH, Kim TH, Lim SH, Kim Y, Lee YA, et al. The effects of repetitive transcranial magnetic stimulation on eating behaviors and body weight in obesity: a randomized controlled study. Brain Stimul. 2018;11(3):528–35.

    Article  PubMed  Google Scholar 

  62. Kelly JF, Stout RL, Magill M, Tonigan JS, Pagano ME. Mechanisms of behavior change in alcoholics anonymous: does Alcoholics Anonymous lead to better alcohol use outcomes by reducing depression symptoms? Addiction. 2010;105(4):626–36.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Tonigan JS, Toscova R, Miller WR. Meta-analysis of the literature on Alcoholics Anonymous: sample and study characteristics moderate findings. J Stud Alcohol. 1996;57(1):65–72.

    Article  CAS  PubMed  Google Scholar 

  64. Donovan DM, Ingalsbe MH, Benbow J, Daley DC. 12-step interventions and mutual support programs for substance use disorders: an overview. Soc Work Public Health. 2013;28(3–4):313–32.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Tonigan JS. Spirituality and alcoholics anonymous. South Med J. 2007;100(4):437–40.

    Article  PubMed  Google Scholar 

  66. Tonigan JS. Alcoholics anonymous outcomes and benefits. Recent Dev Alcohol. 2008;18:357–72.

    Article  PubMed  Google Scholar 

  67. Wilcox CE, Pearson MR, Tonigan JS. Effects of long-term AA attendance and spirituality on the course of depressive symptoms in individuals with alcohol use disorder. Psychol Addict Behav. 2015;29(2):382–91.

    Article  PubMed  PubMed Central  Google Scholar 

  68. MATCH. Matching alcoholism treatments to client heterogeneity: project MATCH posttreatment drinking outcomes. J Stud Alcohol. 1997;58(1):7–29.

    Article  Google Scholar 

  69. Rodriguez-Martin BC, Gallego-Arjiz B. Overeaters anonymous: a mutual-help fellowship for food addiction recovery. Front Psychol. 2018;9:1491.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Russell-Mayhew S, von Ranson KM, Masson PC. How does overeaters anonymous help its members? A qualitative analysis. Eur Eat Disord Rev. 2010;18(1):33–42.

    Article  PubMed  Google Scholar 

  71. Grimm JW, Sauter F. Environmental enrichment reduces food seeking and taking in rats: a review. Pharmacol Biochem Behav. 2020;190:172874.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Sun Y, Li Y, Bao Y, Meng S, Sun Y, Schumann G, et al. Brief report: increased addictive internet and substance use behavior during the COVID-19 pandemic in China. Am J Addict. 2020;29(4):268–70.

    Article  PubMed  Google Scholar 

  73. Rolland B, Haesebaert F, Zante E, Benyamina A, Haesebaert J, Franck N. Global changes and factors of increase in caloric/salty food intake, screen use, and substance use during the early COVID-19 containment phase in the general population in France: survey study. JMIR Public Health Surveill. 2020;6(3):e19630.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Cherikh F, Frey S, Bel C, Attanasi G, Alifano M, Iannelli A. Behavioral food addiction during lockdown: time for awareness, time to prepare the aftermath. Obes Surg. 2020;30(9):3585–7.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Van de Graaf RC, Hofstra L. Obesity and covid-19: the role of the food industry. BMJ. 2020;370:m2813.

    Article  PubMed  Google Scholar 

  76. Hayden-Wade HA, Stein RI, Ghaderi A, Saelens BE, Zabinski MF, Wilfley DE. Prevalence, characteristics, and correlates of teasing experiences among overweight children vs. non-overweight peers. Obes Res. 2005;13(8):1381–92.

    Article  PubMed  Google Scholar 

  77. Neumark-Sztainer D, Falkner N, Story M, Perry C, Hannan PJ, Mulert S. Weight-teasing among adolescents: correlations with weight status and disordered eating behaviors. Int J Obes Relat Metab Disord. 2002;26(1):123–31.

    Article  CAS  PubMed  Google Scholar 

  78. Pretlow RA. Addiction to highly pleasurable food as a cause of the childhood obesity epidemic: a qualitative Internet study. Eat Disord. 2011;19(4):295–307.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Carbone EA, Caroleo M, Rania M, Calabro G, Staltari FA, de Filippis R, et al. An open-label trial on the efficacy and tolerability of naltrexone/bupropion SR for treating altered eating behaviours and weight loss in binge eating disorder. Eat Weight Disord. 2021;26:779–88.

    Article  PubMed  Google Scholar 

  80. Hutson PH, Balodis IM, Potenza MN. Binge-eating disorder: clinical and therapeutic advances. Pharmacol Ther. 2018;182:15–27.

    Article  CAS  PubMed  Google Scholar 

  81. Vetter ML, Faulconbridge LF, Webb VL, Wadden TA. Behavioral and pharmacologic therapies for obesity. Nat Rev Endocrinol. 2010;6(10):578–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Rubio G, Martinez-Gras I, Manzanares J. Modulation of impulsivity by topiramate: implications for the treatment of alcohol dependence. J Clin Psychopharmacol. 2009;29(6):584–9.

    Article  CAS  PubMed  Google Scholar 

  83. Maisel NC, Blodgett JC, Wilbourne PL, Humphreys K, Finney JW. Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful? Addiction. 2013;108(2):275–93.

    Article  PubMed  Google Scholar 

  84. Khalil H, Ellwood L, Lord H, Fernandez R. Pharmacological treatment for obesity in adults: an umbrella review. Ann Pharmacother. 2020;54(7):691–705.

    Article  PubMed  Google Scholar 

  85. Jung J, Fugh-Berman A. Marketing messages in continuing medical education (CME) modules on binge-eating disorder (BED). J Am Board Fam Med. 2020;33(2):240–51.

    Article  PubMed  Google Scholar 

  86. Brady KT, Gray KM, Tolliver BK. Cognitive enhancers in the treatment of substance use disorders: clinical evidence. Pharmacol Biochem Behav. 2011;99(2):285–94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Spencer RC, Devilbiss DM, Berridge CW. The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex. Biol Psychiatry. 2015;77(11):940–50.

    Article  CAS  PubMed  Google Scholar 

  88. Moeller FG, Schmitz JM, Herin D, Kjome KL. Use of stimulants to treat cocaine and methamphetamine abuse. Curr Psychiatry Rep. 2008;10(5):385–91.

    Article  PubMed  Google Scholar 

  89. Joos L, Goudriaan AE, Schmaal L, Fransen E, van den Brink W, Sabbe BG, et al. Effect of modafinil on impulsivity and relapse in alcohol dependent patients: a randomized, placebo-controlled trial. Eur Neuropsychopharmacol. 2013;23(8):948–55.

    Article  CAS  PubMed  Google Scholar 

  90. Davis C, Levitan RD, Kaplan AS, Kennedy JL, Carter JC. Food cravings, appetite, and snack-food consumption in response to a psychomotor stimulant drug: the moderating effect of “food-addiction”. Front Psychol. 2014;5:403.

    Article  PubMed  PubMed Central  Google Scholar 

  91. Hicks C, Sabino V, Cottone P. The alpha-1 adrenergic receptor antagonist prazosin reduces binge-like eating in rats. Nutrients. 2020;12(6):1569.

    Article  CAS  PubMed Central  Google Scholar 

  92. Wilcox CE, Tonigan JS, Bogenschutz MP, Clifford J, Bigelow R, Simpson T. A randomized, placebo-controlled, clinical trial of prazosin for the treatment of alcohol use disorder. J Addict Med. 2018;12(5):339–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Clasen MM, Riley AL, Davidson TL. Hippocampal-dependent inhibitory learning and memory processes in the control of eating and drug taking. Curr Pharm Des. 2020;26(20):2334–52.

    Article  CAS  PubMed  Google Scholar 

  94. Farr OM, Sofopoulos M, Tsoukas MA, Dincer F, Thakkar B, Sahin-Efe A, et al. GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial. Diabetologia. 2016;59(5):954–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Hernandez NS, Schmidt HD. Central GLP-1 receptors: novel molecular targets for cocaine use disorder. Physiol Behav. 2019;206:93–105.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Ben-Porat T, Weiss R, Sherf-Dagan S, Rottenstreich A, Kaluti D, Khalaileh A, et al. Food addiction and binge eating during one year following sleeve gastrectomy: prevalence and implications for postoperative outcomes. Obes Surg. 2021;31(2):603–11.

    Article  PubMed  Google Scholar 

  97. Sarkar S, Kochhar KP, Khan NA. Fat addiction: psychological and physiological trajectory. Nutrients. 2019;11(11):2785.

    Article  CAS  PubMed Central  Google Scholar 

  98. Jimenez-Murcia S, Aguera Z, Paslakis G, Munguia L, Granero R, Sanchez-Gonzalez J, et al. Food addiction in eating disorders and obesity: analysis of clusters and implications for treatment. Nutrients. 2019;11(11):2633.

    Article  CAS  PubMed Central  Google Scholar 

  99. Murray SM, Tweardy S, Geliebter A, Avena NM. A longitudinal preliminary study of addiction-like responses to food and alcohol consumption among individuals undergoing weight loss surgery. Obes Surg. 2019;29(8):2700–3.

    Article  PubMed  Google Scholar 

  100. Pepino MY, Stein RI, Eagon JC, Klein S. Bariatric surgery-induced weight loss causes remission of food addiction in extreme obesity. Obesity. 2014;22(8):1792–8.

    Article  PubMed  Google Scholar 

  101. Sevincer GM, Konuk N, Bozkurt S, Coskun H. Food addiction and the outcome of bariatric surgery at 1-year: prospective observational study. Psychiatry Res. 2016;244:159–64.

    Article  PubMed  Google Scholar 

  102. Ivezaj V, Wiedemann AA, Grilo CM. Food addiction and bariatric surgery: a systematic review of the literature. Obes Rev. 2017;18(12):1386–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Higgins GA, Sellers EM, Fletcher PJ. From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists. Trends Pharmacol Sci. 2013;34(10):560–70.

    Article  CAS  PubMed  Google Scholar 

  104. Higgins GA, Zeeb FD, Fletcher PJ. Role of impulsivity and reward in the anti-obesity actions of 5-HT2C receptor agonists. J Psychopharmacol. 2017;31(11):1403–18.

    Article  CAS  PubMed  Google Scholar 

  105. Blundell JE, Dulloo AG, Salvador J, Fruhbeck G, EASO SAB Working Group on BMI. Beyond BMI--phenotyping the obesities. Obes Facts. 2014;7(5):322–8.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Field AE, Camargo CA Jr, Ogino S. The merits of subtyping obesity: one size does not fit all. JAMA. 2013;310(20):2147–8.

    Article  CAS  PubMed  Google Scholar 

  107. Ziauddeen H, Fletcher PC. Is food addiction a valid and useful concept? Obes Rev. 2013;14(1):19–28.

    Article  CAS  PubMed  Google Scholar 

  108. Dishman E. Precision medicine. 2018. https://www.nih.gov/precision-medicine-initiative-cohort-program. Accessed 2018.

  109. Bearden CE, Thompson PM. Emerging global initiatives in neurogenetics: the enhancing neuroimaging genetics through meta-analysis (ENIGMA) consortium. Neuron. 2017;94(2):232–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Grodin EN, Bujarski S, Venegas A, Baskerville WA, Nieto SJ, Jentsch JD, et al. Reward, relief and habit drinking: initial validation of a brief assessment tool. Alcohol Alcohol. 2019;54(6):574–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  111. Forman EM, Shaw JA, Goldstein SP, Butryn ML, Martin LM, Meiran N, et al. Mindful decision making and inhibitory control training as complementary means to decrease snack consumption. Appetite. 2016;103:176–83.

    Article  PubMed  Google Scholar 

  112. Van Strien T, Van de Laar FA. Intake of energy is best predicted by overeating tendency and consumption of fat is best predicted by dietary restraint: a 4-year follow-up of patients with newly diagnosed type 2 diabetes. Appetite. 2008;50(2–3):544–7.

    Article  PubMed  Google Scholar 

  113. Lin YS, Tung YT, Yen YC, Chien YW. Food addiction mediates the relationship between perceived stress and body mass index in Taiwan young adults. Nutrients. 2020;12(7):1951.

    Article  PubMed Central  Google Scholar 

  114. Lin CY, Cheung P, Imani V, Griffiths MD, Pakpour AH. The mediating effects of eating disorder, food addiction, and insomnia in the association between psychological distress and being overweight among Iranian adolescents. Nutrients. 2020;12(5):1371.

    Article  PubMed Central  Google Scholar 

  115. Romano KA, Heron KE, Amerson R, Howard LM, MacIntyre RI, Mason TB. Changes in disordered eating behaviors over 10 or more years: a meta-analysis. Int J Eat Disord. 2020;53(7):1034–55.

    Article  PubMed  Google Scholar 

  116. Elsenburg LK, Smidt N, Liefbroer AC. The longitudinal relation between accumulation of adverse life events and body mass index from early adolescence to young adulthood. Psychosom Med. 2017;79(3):365–73.

    Article  PubMed  Google Scholar 

  117. Elsenburg LK, van Wijk KJE, Liefbroer AC, Smidt N. Accumulation of adverse childhood events and overweight in children: a systematic review and meta-analysis. Obesity. 2017;25(5):820–32.

    Article  PubMed  Google Scholar 

  118. Bou Khalil R, Sleilaty G, Richa S, Seneque M, Iceta S, Rodgers R, et al. The impact of retrospective childhood maltreatment on eating disorders as mediated by food addiction: a cross-sectional study. Nutrients. 2020;12(10):2969.

    Article  PubMed Central  Google Scholar 

  119. Cope EC, Gould E. New evidence linking obesity and food addiction. Biol Psychiatry. 2017;81(9):734–6.

    Article  PubMed  Google Scholar 

  120. Sinha R. Role of addiction and stress neurobiology on food intake and obesity. Biol Psychol. 2018;131:5–13.

    Article  PubMed  Google Scholar 

  121. Loxton NJ, Tipman RJ. Reward sensitivity and food addiction in women. Appetite. 2017;115:28–35.

    Article  PubMed  Google Scholar 

  122. Gearhardt AN, Boswell RG, White MA. The association of “food addiction” with disordered eating and body mass index. Eat Behav. 2014;15(3):427–33.

    Article  PubMed  PubMed Central  Google Scholar 

  123. Ferrario CR. Food addiction and obesity. Neuropsychopharmacology. 2017;42(1):361.

    Article  PubMed  Google Scholar 

  124. Seid H, Rosenbaum M. Low carbohydrate and low-fat diets: what we don’t know and why we should know it. Nutrients. 2019;11(11):2749.

    Article  CAS  PubMed Central  Google Scholar 

  125. Romero X, Aguera Z, Granero R, Sanchez I, Riesco N, Jimenez-Murcia S, et al. Is food addiction a predictor of treatment outcome among patients with eating disorder? Eur Eat Disord Rev. 2019;27(6):700–11.

    Article  PubMed  Google Scholar 

  126. Hilker I, Sanchez I, Steward T, Jimenez-Murcia S, Granero R, Gearhardt AN, et al. Food addiction in bulimia nervosa: clinical correlates and association with response to a brief psychoeducational intervention. Eur Eat Disord Rev. 2016;24(6):482–8.

    Article  PubMed  Google Scholar 

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Wilcox, C.E. (2021). Clinical Applications of the Food Addiction Concept. In: Food Addiction, Obesity, and Disorders of Overeating. Springer, Cham. https://doi.org/10.1007/978-3-030-83078-6_14

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