Abstract
The concept of food addiction (FA) remains controversial with research being in the nascent stages; FA like any addiction can have a devastating impact on the lives of those afflicted. There exists a clinical need for treatment strategies for those affected. This article reviews potential treatment strategies for FA. The treatment strategies target four core behaviours of the addiction phenotype specifically craving through the opioid system, impulsivity as a personality trait, compulsivity through the serotonergic system and lastly motivation through the dopaminergic system. A range of pharmacological and psychological interventions are reviewed. Future research should seek to test and validate the proposed clinical treatment strategies.
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References
Rogers PJ, Smit HJ (2000) Food craving and food addiction: a critical review of the evidence from a biopsychosocial perspective. Pharmacol Biochem Behav 66(1):3–14. doi:10.1016/S0091-3057(00)00197-0
Meule A, Gearhardt AN (2014) Food addiction in the light of the DSM-5. Nutrients 6(9):3653–3671. doi:10.3390/nu6093653
Davis C (2017) An introduction to the special issue on ‘food addiction’. Appetite. doi:10.1016/j.appet.2017.03.043
American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders (4th ed, text rev.). American Psychiatric Association, Washington, DC
Gearhardt AN, Corbin WR, Brownell KD (2009) Preliminary validation of the Yale Food Addiction Scale. Appetite 52(2):430–436. doi:10.1016/j.appet.2008.12.003
Ziauddeen H, Farooqi IS, Fletcher PC (2012) Obesity and the brain: how convincing is the addiction model? Nat Rev Neurosci 13(4):279–286. doi:10.1038/nrn3212
Moreno C, Tandon R (2011) Should overeating and obesity be classified as an addictive disorder in DSM-5? Curr Pharm Des 17:1128–1131. doi:10.2147/138161211795656701
Schulte EM, Avena NM, Gearhardt AN (2015) Which foods may be addictive? The roles of processing, fat content, and glycemic load. PLoS One 10(21):e0117959. doi:10.1371/journal.pone0117959
Gearhardt AN, Grilo CM, DiLeone J, Brownell D, Potenza MN (2011) Can food be addictive? Public health and policy implications. Addiction 106:1208–1212. doi:10.1111/j.1360-0443.2010.03301.x
Lerma-Cabrera JM, Carvajal F, Lopez-Legarrea P (2016) Food addiction as a new piece of the obesity framework. Open Nutr J. doi:10.1186/s12937-016-0124-6
Long CG, Blundell JE, Finlayson G (2015) A systematic review of the application and correlates of YFAS-diagnosed ‘Food Addiction’ in humans: are eating-related addictions a cause for concern or empty concepts? Obes Facts 8:386–401. doi:10.1159/000442403
Avena NM, Rada P, Hoebel BG (2008) Evidence for sugar addiction: behavioural and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev 32:20–39. doi:10.1016/j.neubiorev.2007.04.019
Ahmed SH, Guillem K, Vandaele Y (2013) Sugar addiction: pushing the drug- sugar analogy to the limit. Curr Opin Clin Nutr Metab Care 16(4):434–439. doi:10.1097/MCO.0b013e328361c8b8
Benton D (2010) The plausibility of sugar addiction and its role in obesity and eatinmg disorders. Clin Nutr 29:288–303. doi:10.1016/j.clnu.2009.12.001
Cocores JA, Gold MS (2009) The salted food addiction hypothesis may explain overeating and the obesity epidemic. Med Hypotheses 73:892–899. doi:10.1016/j.mehy.2009.06.049
Corwin RL, Grigson PS (2009) Symposium overview—food addiction: fact or fiction? J Nutr 139:617–619. doi:10.3945/jn.108.097691
Pelchat ML (2009) Food addiction in humans. J Nutr 139:620–622. doi:10.3945/jn.108.097816
Smith DS, Robbins TW (2013) The neurobiological underpinnings of obesity and binge eating: a rationale for adopting the food addiction model. Biol Psychiatry 73:804–810. doi:10.1016/j.biopsych.2012.08.026
Hebebrand J, Albayrak O, Adan R, Antel J, Dieguez C, de Jong J, Leng G, Menzies J, Mercer J, Murphy M, van der Plasse G, Dickson SL (2014) “Eating addiction”, rather than “food addiction”, better captures addictive like eating behaviour. Neurosci Biobehav Rev 47:295–306. doi:10.1016/j.neubiorev.2014.08.016
Albayrak O, Wolfe SM, Hebebrand J (2012) Does food addiction exist? A phenomenological discussion based on the psychiatric classification of substance related disorders and addiction. Obes Facts 5:165–179. doi:10.1159/000338310
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders: DSM-5. American Psychiatric Association, Washington, DC
Gearhardt AN, Corbin WR, Brownell KD (2016) Development of the Yale Food Addiction Scale Version 2.0. Psychol Addict Behav 30(1):113–121. doi:10.1037/adb0000136
Dietz WH (2015) The response of the US Centers for Disease Control and prevention to the obesity epidemic. Annu Rev Publ Health 36:575–596. doi:10.1146/annurev-publhealth-031914-122415
Hendrie GA, Ullah S, Scott JA, Gray J, Berry N, Carter P, Cobiac L, Coveney J (2015) Past and projected trends of body mass index and weight status in South Australia: 2003 to 2019. Aust N Z J Public Health 39(6):536–543. doi:10.1111/1753-6405.12442
Belin-Rauscent A, Fouyssac M, Bonci A, Belin D (2016) How preclinical models evolved to resemble the diagnostic criteria of drug addiction. J Biol Psychiatry 79(1):39–46. doi:10.1016/j.biopsych.2015.01.004
Martin CS, Langenbucher JW, Chung T, Sher KJ (2014) Truth or consequences in the diagnosis of substance use disorders. Addiction 109:1773–1778. doi:10.1111/add.12615
Davis C, Carter JC (2009) Compulsive over eating as an addiction disorder. A review of theory and evidence. Appetite 53:1–8. doi:10.1016/j.appet.2009.05.018
Skinner MD, Aubin H (2010) Cravings place in addiction theory: contributions of major models. Neurosci Biobehav Rev 34:606–623. doi:10.1016/j.neubiorev.2009.11.024
Davis CA, Levitan RD, Reid C, Carter JC, Kaplan AS, Patte KA, King N, Curtis C, Kennedy JL (2009) Dopamine for “wanting” and “opioids” for liking: a comparison of obese adults with and without binge eating. Obesity 17(6):1220–1225. doi:10.1098/oby.2009.52
Clark L (2014) Disordered gambling: the evolving concept of behavioural addiction. Ann N Y Acad Sci Addict Rev 1327:46–61. doi:10.1111/nyas.12558
Giuliano C, Cottone P (2015) The role of the opioid system in binge eating disorder. CNS Spectr 20(6):537–545. doi:10.1017/S1092852915000668
McElroy SL, Guerdjikova AI, Mori N, Keck PE (2015) Psychopharmacologic treatment of eating disorders: emerging findings. Curr Psychiatry Rep 17:35. doi:10.1007/s11920-015-0573-1
Mason AE, Laraia B, Daubenmier J, Hecht FM, Lustig RH, Puterman E, Adler N, Dallman M, Kiernan M, Gearhardt AN, Epel ES (2015) Putting the brakes on the “drive to eat”: pilot effects of naltrexone and reward-based eating on food cravings among obese women. Eating Behav 19:53–56. doi:10.1016/j.eatbeh.2015.06.008
Grosshans M, Loeber S, Kiefer F (2011) Implications from addiction research towards the understanding and treatment of obesity. Addict Biol 16:189–198. doi:10.1111/j.1369-1600.2010.00300
Potenza MN (2007) To do or not to do? The complexities of addiction, motivation, self-control, and impulsivity. Am J Psychiatry 164(1):4–6. doi:10.1176/appi.ajp.164.1.4
Colman A (2015) Impulsivity. In: A dictionary of psychology. Oxford University Press, Oxford. http://www.oxfordreference.com.ezproxy.uow.edu.au/view/10.1093/acref/9780199659780199657681-e-9507. Accessed 14 Apr 2016
Voon V (2015) Cognitive biases in binge eating disorder: the hijacking of decision making. CNS Spectr 20(6):566–573. doi:10.1017/S1092852915000681
Schag K, Schonleber J, Teufel M, Zipfel S, Giel KE (2013) Food-related impulsivity in obesity and binge eating disorder—a systematic review. Obes Rev 14:477–495. doi:10.1111/obr.12017
Verdejo-Garcia A, Lawrence AJ, Clark L (2008) Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. Neurosci Biobehav Rev 32:777–810. doi:10.1016/j.neubiorev.2007.11.003
Robbins TW, Clark L (2015) Behavioral addictions. Curr Opin Neurobiol 30:66–72. doi:10.1016/j.conb.2014.09.005
Grant JE, Chamberlain SR (2014) Impulsive action and impulsive choice across substance and behavioural addictions: cause or consequence? Addict Behav 39:1632–1639. doi:10.1016/j.addbeh.2014.04.022
Staiger PK, Dawe S, Richardson B, Hall K, Kambouropoulos N (2014) Modifying the risk associated with an impulsive temperament: a prospective study of drug dependence treatment. Addict Behav 39:1676–1681. doi:10.1016/j.addbeh.2014.05.001
Stevens L, Verdejo-Garcia A, Goudriaan AE, Roeyers H, Dom G, Vanderplasschen W (2014) Impulsivity as a vulnerability factor for poor treatment outcomes: a review of neurocognitive findings among individuals with substance use disorders. J Subst Abuse Treat 47:58–72. doi:10.1016/j.jsat.2014.01.008
Saunders BT, Robinson TE (2013) Individual variation in resisting temptation: implications for addiction. Neurosci Biobehav Rev 37:1955–1975. doi:10.1016/j.neubiorev.2013.02.008
McElroy SL, Mitchell JE, Wilfey D, Gasior M, Ferreira-Cornwell C, McKay M, Wang J, Whitaker T, Hudson JI (2015) Lisdexamfetamine Dimesylate effects on binge eating behaviour and obsessive-compulsive and impulsive features in adults with binge eating disorder. Eur Eat Disord Rev. doi:10.1002/erv.2418
Kenny PJ (2011) Common cellular and molecular mechanisms in obesity and drug addiction. Nat Rev Neurosci 12(11):638–651. doi:10.1038/nrn3105
Everitt BJ, Robbins TW (2013) From the ventral to the dorsal striatum: devolving views of their roles in drug addiction. Neurosci Biobehav Rev 37(9 Part A):1946–1954. doi:10.1016/j.neubiorev.2013.02.010
Berkman ND, Brownley KA, Peat CM, Lohr KN, Cullen KE, Morgan LC, Bann CM, Wallace IF, Bulik CM (2015) Management and outcomes of binge eating disorder. Comparative Effectiveness Review No. 160. (Prepared by RTI International—University of North Carolina Evidence-based Practice Centre under Contract No. 290-2012-00008-1.) AHRQ Publication No. 15(16)-EHC030-EF. Agency for Healthcare Research and Quality, Rockville, December 2015. http://www.effectivehealthcare.ahqr.gov/reports/final.cfm
Hurley MM, Resch JM, Maunze B, Frenkel MM, Baker DA, Choi S (2016) N-Acetylcysteine decreases binge eating in a rodent model. Int J Obes 40:1183–1186. doi:10.1038/ijo.2016.31
Dean O, Giorlando F, Berk M (2011) N-Acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psychiatry Neurosci 36(2):78–86. doi:10.1503/jpn.100057
McElroy SL, Guerdjikova AI, Mori N, Munoz MR, Keck PE (2015) Overview of the treatment of binge eating disorder. CNS Spectr 20(6):546–556. doi:10.1017/S1092852915000759
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Vella, SL.C., Pai, N.B. A narrative review of potential treatment strategies for food addiction. Eat Weight Disord 22, 387–393 (2017). https://doi.org/10.1007/s40519-017-0400-2
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DOI: https://doi.org/10.1007/s40519-017-0400-2