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Role of Heat Shock Proteins in Immune Modulation in Malaria

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Heat Shock Proteins of Malaria

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1340))

Abstract

Malaria is one of the major parasitic killer diseases worldwide. Severe cases of malaria are mostly in children under the age of 5 years due to their naïve immune system and in pregnant women with weakened immune responses. Inflammatory immune responses against the parasite involve complement activation as well as the antibody and effector cell-mediated immune system. However, after an infection with Plasmodium falciparum (P. falciparum), the most dangerous malaria species, the host-derived immunity is often insufficient to completely inhibit the infection cycles of the parasite in red blood cells for yet unknown reasons. In the present chapter we aim to elucidate the role of the host’s and the parasite’s heat shock proteins (HSPs) in the development of a novel anti-malaria therapeutic approach.

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Authors and Affiliations

  1. Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa

    Tawanda Zininga

  2. Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany

    Evelyn Böttger

  3. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar and Central Institute for Translational Cancer Research TU München (TranslaTUM), Munich, Germany

    Gabriele Multhoff

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  1. Tawanda Zininga
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  2. Evelyn Böttger
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  3. Gabriele Multhoff
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Correspondence to Tawanda Zininga .

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Editors and Affiliations

  1. Department of Biochemistry, University of Venda, Thohoyandou, South Africa

    Addmore Shonhai

  2. Department of Cell Biology, University of Geneva, Genève, Switzerland

    Didier Picard

  3. The Vice Chancellery, The University of Notre Dame Australia, Fremantle, WA, Australia

    Gregory L. Blatch

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Zininga, T., Böttger, E., Multhoff, G. (2021). Role of Heat Shock Proteins in Immune Modulation in Malaria. In: Shonhai, A., Picard, D., Blatch, G.L. (eds) Heat Shock Proteins of Malaria. Advances in Experimental Medicine and Biology, vol 1340. Springer, Cham. https://doi.org/10.1007/978-3-030-78397-6_7

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