Skip to main content

Upper Extremity Nerve Injuries and Compression Syndromes

  • Chapter
  • First Online:
Tips and Tricks in Plastic Surgery

Abstract

Peripheral nerve injuries and compression syndromes of the upper extremity are two disease entities that present diagnostic and therapeutic challenges. Nerve dysfunction can produce profound functional disability from numbness, paresthesia, pain, weakness, and loss of use of the extremity. Management ranges from immediate primary repair, observation with serial electrodiagnostic testing, and possible delayed repair, to nerve grafting with distal nerve transfers. Expected outcomes may be as great as functional muscle contraction or limited to return of protective sensation. The compressive syndromes often present more gradually as pressure or nerve impingement at known locations of compression symptoms. Though compression syndromes may occur acutely, dictating emergent decompression, first-line management is generally nonoperative splinting and activity modification with operative decompression reserved for recurrence and recalcitrant cases. Ultimately, for both nerve injuries and compressive syndromes, accurate diagnosis is required to determine the correct treatment and the level at which to intervene. In this chapter, we discuss nerve pathophysiology, principles for optimal nerve injury reconstruction and management, and the upper extremity compressive syndromes and their respective management.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Lee SK, Wolfe SW. Peripheral nerve injury and repair. J Am Acad Orthop Surg. 2000;8(4):243–52. https://doi.org/10.5435/00124635-200007000-00005.

    Article  CAS  PubMed  Google Scholar 

  2. Lowe JB, Mackinnon SE. Management of secondary cubital tunnel syndrome. Plast Reconstr Surg. 2004;113(1):e1–e16. https://doi.org/10.1097/01.PRS.0000097287.10955.CC.

    Article  Google Scholar 

  3. Mizisin AP, Weerasuriya A. Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult. Acta Neuropathol. 2011;121(3):291–312. https://doi.org/10.1007/s00401-010-0783-x.

    Article  CAS  PubMed  Google Scholar 

  4. Schmauss D, Finck T, Megerle K, Machens HG, Lohmeyer JA. The normal sensibility of the hand declines with age – a proclamation for the use of delta two-point discrimination values for sensibility assessment after nerve reconstruction. J Peripher Nerv Syst. 2014;19(3):197–204. https://doi.org/10.1111/jns.12085.

    Article  PubMed  Google Scholar 

  5. Smith J, Siddiqui S, Ebraheim N. Comprehensive summary of anastomoses between the median and ulnar nerves in the forearm and hand. J Hand Microsurg. 2019;11(01):1–5. https://doi.org/10.1055/s-0038-1672335.

    Article  CAS  PubMed  Google Scholar 

  6. Kamerath JH, Epstein DK, Fitzpatrick KF. The Froment-Rauber nerve: a case report and review. Muscle Nerve. 2013;47(5):768–71. https://doi.org/10.1002/mus.23741.

    Article  PubMed  Google Scholar 

  7. Moore AM, Wagner IJ, Fox IK. Principles of nerve repair in complex wounds of the upper extremity. Semin Plast Surg. 2015;29(1):40–7. https://doi.org/10.1055/s-0035-1544169.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Padua L, Coraci D, Erra C, Pazzaglia C, Paolasso I, Loreti C, et al. Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurol. 2016;15(12):1273–84. https://doi.org/10.1016/S1474-4422(16)30231-9.

    Article  PubMed  Google Scholar 

  9. Calandruccio JH, Thompson NB. Carpal tunnel syndrome: making evidence-based treatment decisions. Orthop Clin North Am. 2018;49(2):223–9. https://doi.org/10.1016/j.ocl.2017.11.009.

    Article  PubMed  Google Scholar 

  10. Upton ARM, Mccomas AJ. The double crush in nerve-entrapment syndromes. Lancet. 1973;302(7825):359–62. https://doi.org/10.1016/S0140-6736(73)93196-6.

    Article  Google Scholar 

  11. Mackinnon SE. Double and multiple “crush” syndromes. Double and multiple entrapment neuropathies. Hand Clin. 1992;8(2):369–90.

    Article  CAS  Google Scholar 

  12. Hurst LC, Weissberg D, Carroll RE. The relationship of the double crush to carpal tunnel syndrome (an analysis of 1,000 cases of carpal tunnel syndrome). J Hand Surg Br. 1985;10(2):202–4.

    Article  CAS  Google Scholar 

  13. Sears ED, Lu YT, Wood SM, Nasser JS, Hayward RA, Chung KC, et al. Diagnostic testing requested before surgical evaluation for carpal tunnel syndrome. J Hand Surg Am. 2017;42(8):623–9.e1. https://doi.org/10.1016/j.jhsa.2017.05.006.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Lanz U. Anatomical variations of the median nerve in the carpal tunnel. J Hand Surg Am. 1977;2(1):44–53. https://doi.org/10.1007/BF00184911.

    Article  CAS  PubMed  Google Scholar 

  15. Mofikoya BO, Ugburo AO. Anatomic variations in the palmar cutaneous branch of the median nerve among adults in Lagos, Nigeria. Niger J Surg. 2012;18(2):85–7. https://doi.org/10.4103/1117-6806.103112.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Xu X, Lao J, Zhao X. How to prevent injury to the palmar cutaneous branch of median nerve and ulnar nerve in a palmar incision in carpal tunnel release, a cadaveric study. Acta Neurochir. 2013;155(9):1751–5. https://doi.org/10.1007/s00701-013-1764-3.

    Article  PubMed  Google Scholar 

  17. Zhang D, Earp BE, Blazar P. Utility of ‘baseline’ electrodiagnostic studies for carpal tunnel release. J Hand Surg Eur Vol. 2019;44(3):273–7. https://doi.org/10.1177/1753193418815546.

    Article  CAS  PubMed  Google Scholar 

  18. Graham B, Peljovich AE, Afra R, Cho MS, Gray R, Stephenson J, et al. The American Academy of Orthopaedic Surgeons evidence-based clinical practice guideline on: management of carpal tunnel syndrome. J Bone Joint Surg Am. 2016;98(20):1750–4. https://doi.org/10.2106/JBJS.16.00719.

    Article  PubMed  Google Scholar 

  19. Evers S, Bryan AJ, Sanders TL, Gunderson T, Gelfman R, Amadio PC. Corticosteroid injections for carpal tunnel syndrome: long-term follow-up in a population-based cohort. Plast Reconstr Surg. 2017;140(2):338–47. https://doi.org/10.1097/PRS.0000000000003511.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Atroshi I, Hofer M, Larsson GU, Ranstam J. Extended follow-up of a randomized clinical trial of open vs endoscopic release surgery for carpal tunnel syndrome. JAMA. 2015;314(13):1399–401. https://doi.org/10.1001/jama.2015.12208.

    Article  PubMed  Google Scholar 

  21. Sayegh ET, Strauch RJ. Open versus endoscopic carpal tunnel release: a meta-analysis of randomized controlled trials. Clin Orthop Relat Res. 2015;473(3):1120–32. https://doi.org/10.1007/s11999-014-3835-z.

    Article  PubMed  Google Scholar 

  22. Williamson ERC, Vasquez Montes D, Melamed E. Multistate comparison of cost, trends, and complications in open versus endoscopic carpal tunnel release. Hand (N Y). 2019:155894471983702. https://doi.org/10.1177/1558944719837020.

  23. Ilyas AM, Miller AJ, Graham JG, Matzon JL. Pain management after carpal tunnel release surgery: a prospective randomized double-blinded trial comparing acetaminophen, ibuprofen, and oxycodone. J Hand Surg Am. 2018;43(10):913–9. https://doi.org/10.1016/j.jhsa.2018.08.011.

    Article  PubMed  Google Scholar 

  24. Jones NF, Ahn HC, Eo S. Revision surgery for persistent and recurrent carpal tunnel syndrome and for failed carpal tunnel release. Plast Reconstr Surg. 2012;129(3):683–92. https://doi.org/10.1097/PRS.0b013e3182402c37.

    Article  CAS  PubMed  Google Scholar 

  25. Zhang D, Blazar P, Earp BE. Rates of complications and secondary surgeries of mini-open carpal tunnel release. Hand (N Y). 2019;14(4):471–6. https://doi.org/10.1177/1558944718765226.

    Article  Google Scholar 

  26. Dang AC, Rodner CM. Unusual compression neuropathies of the forearm, part II: median nerve. J Hand Surg Am. 2009;34(10):1915–20. https://doi.org/10.1016/j.jhsa.2009.10.017.

    Article  PubMed  Google Scholar 

  27. Osei DA, Groves AP, Bommarito K, Ray WZ. Cubital tunnel syndrome: incidence and demographics in a national administrative database. Neurosurgery. 2017;80(3):417–20. https://doi.org/10.1093/neuros/nyw061.

    Article  PubMed  Google Scholar 

  28. Mondelli M, Giannini F, Ballerini M, Ginanneschi F, Martorelli E. Incidence of ulnar neuropathy at the elbow in the province of Siena (Italy). J Neurol Sci. 2005;234(1–2):5–10. https://doi.org/10.1016/j.jns.2005.02.010.

    Article  PubMed  Google Scholar 

  29. Chen S-H, Tsai T-M. Ulnar tunnel syndrome. J Hand Surg Am. 2014;39(3):571–9. https://doi.org/10.1007/978-1-4471-6560-6_15.

    Article  PubMed  Google Scholar 

  30. Hutchison RL, Rayan G. Diagnosis of cubital tunnel syndrome. J Hand Surg Am. 2011;36(9):1519–21. https://doi.org/10.1016/j.jhsa.2011.03.021.

    Article  PubMed  Google Scholar 

  31. Landau ME, Campbell WW. Clinical features and electrodiagnosis of ulnar neuropathies. Phys Med Rehabil Clin N Am. 2013;24(1):49–66. https://doi.org/10.1016/j.pmr.2012.08.019.

    Article  PubMed  Google Scholar 

  32. Shah CM, Calfee RP, Gelberman RH, Goldfarb CA. Outcomes of rigid night splinting and activity modification in the treatment of cubital tunnel syndrome. J Hand Surg Am. 2013;38(6):1125–30.e1. https://doi.org/10.1016/j.jhsa.2013.02.039.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Mackinnon SE, Novak CB. Compression neuropathies. In: Green DP, Hotchkiss RN, Pederson WC, Wolfe SW, editors. Green’s operative hand surgery. 6th ed. Philadelphia: Elsevier; 2011.

    Google Scholar 

  34. Boone S, Gelberman RH, Calfee RP. The management of cubital tunnel syndrome. J Hand Surg Am. 2015;40(9):1897–904. https://doi.org/10.1016/j.jhsa.2015.03.011.

    Article  PubMed  Google Scholar 

  35. Benedikt S, Parvizi D, Feigl G, Koch H. Anatomy of the medial antebrachial cutaneous nerve and its significance in ulnar nerve surgery: an anatomical study. J Plast Reconstr Aesthet Surg. 2017;70(11):1582–8. https://doi.org/10.1016/j.bjps.2017.06.025.

    Article  CAS  PubMed  Google Scholar 

  36. Elhassan B, Steinmann SP. Entrapment neuropathy of the ulnar nerve. J Am Acad Orthop Surg. 2007;15(11):672–81. https://doi.org/10.5435/00124635-200711000-00006.

    Article  PubMed  Google Scholar 

  37. Moradi A, Ebrahimzadeh MH, Jupiter JB. Radial tunnel syndrome, diagnostic and treatment dilemma. Arch Bone Jt Surg. 2015;3(3):156–62.

    PubMed  PubMed Central  Google Scholar 

  38. Thurston A. Radial tunnel syndrome. Orthop Trauma. 2013;27(6):403–8. https://doi.org/10.1016/j.mporth.2013.07.004.

    Article  Google Scholar 

  39. Sarhadi NS, Korday SN, Bainbride LC. Radial tunnel syndrome: diagnosis and management. J Hand Surg Eur Vol. 1998;23(5):617–9. https://doi.org/10.1016/S0266-7681(98)80015-6.

    Article  CAS  Google Scholar 

  40. Marchese J, Coyle K, Cote M, Wolf JM. Prospective evaluation of a single corticosteroid injection in radial tunnel syndrome. Hand (N Y). 2019;14(6):741–5. https://doi.org/10.1177/1558944718787282.

    Article  Google Scholar 

  41. Dang AC, Rodner CM. Unusual compression neuropathies of the forearm, part I: radial nerve. J Hand Surg Am. 2009;34(10):1096–14. https://doi.org/10.1016/j.jhsa.2009.10.016.

    Article  Google Scholar 

  42. Wartenberg R. Cheiralgia paraesthetica. Arch Psychiatr Nervenkr Z Gesamte Neurol Psychiatr. 1932;141(1):145–55.

    Article  Google Scholar 

  43. Pannell WC, Heckmann N, Alluri RK, Sivasundaram L, Stevanovic M, Ghiassi A. Predictors of nerve injury after gunshot wounds to the upper extremity. Hand. 2017;12(5):501–6. https://doi.org/10.1177/1558944716675294.

    Article  PubMed  Google Scholar 

  44. Omid R, Stone MA, Zalavras CG, Marecek GS. Gunshot wounds to the upper extremity. J Am Acad Orthop Surg. 2019;27(7):e301–10. https://doi.org/10.5435/JAAOS-D-17-00676.

    Article  PubMed  Google Scholar 

  45. Smetana BS, Cao J, Merrell GA, Greenberg JA. Testing of direct neurorrhaphy strain. J Hand Surg Am. 2019;44(7):615.e1–6. https://doi.org/10.1016/j.jhsa.2018.09.004.

    Article  Google Scholar 

  46. Brushart TME, Seiler WA. Selective reinnervation of distal motor stumps by peripheral motor axons. Exp Neurol. 1987;97(2):289–300.

    Article  CAS  Google Scholar 

  47. Isaacs J, Safa B. A preliminary assessment of the utility of large-caliber processed nerve allografts for the repair of upper extremity nerve injuries. Hand. 2017;12(1):55–9. https://doi.org/10.1177/1558944716646782.

    Article  PubMed  Google Scholar 

  48. Deslivia MF, Lee HJ, Adikrishna A, Jeon IH. Decellularized nerves for upper limb nerve reconstruction: a systematic review of functional outcomes. J Reconstr Microsurg. 2015;31(9):660–7. https://doi.org/10.1055/s-0035-1558463.

    Article  PubMed  Google Scholar 

  49. Tang P, Kilic A, Konopka G, Regalbuto R, Akelina Y, Gardner T. Histologic and functional outcomes of nerve defects treated with acellular allograft versus cabled autograft in a rat model. Microsurgery. 2013;33(6):460–7. https://doi.org/10.1002/micr.22102.

    Article  PubMed  Google Scholar 

  50. Weber RA, Breidenbach WC, Brown RE, Jabaley ME, Mass DP. A randomized prospective study of polyglycolic acid conduits for digital nerve reconstruction in humans. Plast Reconstr Surg. 2000;106(5):1036–45.

    Article  CAS  Google Scholar 

  51. Safa B, Buncke G. Autograft substitutes: conduits and processed nerve allografts. Hand Clin. 2016;32(2):127–40. https://doi.org/10.1016/j.hcl.2015.12.012.

    Article  PubMed  Google Scholar 

  52. Dvali L, Mackinnon S. Nerve repair, grafting, and nerve transfers. Clin Plast Surg. 2003;30(2):203–21. https://doi.org/10.1016/S0094-1298(02)00096-2.

    Article  PubMed  Google Scholar 

  53. Ray WZ, Mackinnon SE. Management of nerve gaps: autografts, allografts, nerve transfers, and end-to-side neurorrhaphy. Exp Neurol. 2010;223(1):77–85. https://doi.org/10.1016/j.expneurol.2009.03.031.

    Article  PubMed  Google Scholar 

  54. Isaacs J, Patel G, Mallu S, Ugwu-Oju O, Desai A, Borschel G, et al. Effect of reverse end-to-side (supercharging) neurotization in long processed acellular nerve allograft in a rat model. J Hand Surg Am. 2019;44(5):419.e1–419.e10. https://doi.org/10.1016/j.jhsa.2018.07.008.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zubin J. Panthaki .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ghumman, A.E., Chavanon, V.A., Panthaki, Z.J. (2022). Upper Extremity Nerve Injuries and Compression Syndromes. In: Thaller, S.R., Panthaki, Z.J. (eds) Tips and Tricks in Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-78028-9_38

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-78028-9_38

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-78027-2

  • Online ISBN: 978-3-030-78028-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics