Abstract
The anthelminthic compound praziquantel acts against flatworms (platyhelminthes) like tapeworms and bloodsucking worms (trematodes) in case they have infected humans or animals. The present chapter shows its history and ongoing activity.
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Literature on early detections on the efficacy of praziquantel in chronological order showing some of the huge number of initial cooperations of international groups with scientists of Bayer Company, Leverkusen, Germany.
Bibliography: History of important tests of efficacy
Literature on early detections on the efficacy of praziquantel in chronological order showing some of the huge number of initial cooperations of international groups with scientists of Bayer Company, Leverkusen, Germany.
Thomas H, Gönnert R (1977) The efficacy of praziquantel against cestodes in animals. Z Parasitenkd 52:117–127
Gönnert R, Andrews P (1977) Praziquantel, a new board-spectrum antischistosomal agent. Z Parasitenkd 52:129–150
Thomas H, Gönnert R (1978) The efficacy of praziquantel against experimental cysticercosis and hydatidosis. Z Parasitenkd 55:165–179
Becker B, Mehlhorn H, Andrews P, Thomas H (1980a) Scanning and transmission electron microscope studies on the efficacy of praziquantel on Hymenolepis nana (Cestoda) in vitro. Z Parasitenkd 61:121–133
Becker B, Mehlhorn H, Andrews P, Thomas H, Eckert J (1980b) Light and electron microscopic studies on the effect of praziquantel on Schistosoma mansoni, Dicrocoelium dendriticum, and Fasciola hepatica (Trematoda) in vitro. Z Parasitenkd 63:113–128
Becker B, Mehlhorn H, Andrews P, Thomas H (1981) Ultrastructural investigations on the effect of praziquantel on the tegument of five species of cestodes. Z Parasitenkd 64:257–269
Mehlhorn H, Becker B, Andrews P, Thomas H, Frenkel JK (1981) In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni. A light and electron microscopic study. Arzneimittelforschung 31:544–554
Cooperative Group of Treatment of Fasciolopsiasis with Praziquantel (1981) A comparison of the curative effects of praziquantel, bithional and areca pill in the treatment of fasciolopsiasis. Jiangsu Med J 7:5–7
Mehlhorn H, Frenkel JK, Andrews P, Thomas H (1982) Light and electron microscopic studies on Schistosoma mansoni granulomas of mouse livers following treatment with praziquantel. Tropenmed Parasitol 33:229–239
Mehlhorn H, Kojima S, Rim HJ, Ruenwongsa P, Andrews P, Thomas H, Bunnag B (1983) Ultrastructural investigations on the effects of praziquantel on human trematodes from Asia: Clonorchis sinensis, Metagonimus yokogawai, Opisthorchis viverrini, Paragonimus westermani and Schistosoma japonicum. Arzneimittelforschung 33:91–98
Abo-Shady AF, Abdel-Magied SA, Hegazi MM (1983) Praziquantel in treatment of heterophyiasis (a preliminary study). J Egypt Soc Parasitol 13:629–630
Sirisinha S, Puengtomwatanakul S, Sobhon P, Saitongdee P, Wongpayabal P, Mitranonde V, Radomyos P, Bunnag D, Harinasuta T (1984) Alterations of the surface tegument of Opisthorchis viverrini exposed to praziquantel in vitro and in vivo. Southeast Asian J Trop Med Public Health 15:95–103
Wahn V, Mehlhorn H (1984) Four kinds of parasites in an 8-year-old boy. Therapeutic effects of praziquantel against Fasciola hepatica. Dtsch Med Wochenschr 109:1486–1488
Schmahl G, Mehlhorn H (1985) Treatment of fish parasites. 1. Praziquantel effective against Monogenea (Dactylogyrus vastator, Dactylogyrus extensus, Diplozoon paradoxum). Z Parasitenkd 71:727–737
Taraschewski H, Mehlhorn H, Bunnag D, Andrews P, Thomas H (1986) Effects of praziquantel on human intestinal flukes (Fasciolopsis buski and Heterophyes heterophyes). Zentralbl Bakteriol Mikrobiol Hyg A 262:542–550
Staudt U, Schmahl G, Blaschke G, Mehlhorn H (1992) Light and scanning electron microscopy studies on the effects of the enantiomers of praziquantel and its main metabolite on Schistosoma mansoni in vitro. Parasitol Res 78:392–397
Mehlhorn H, Schmahl G, Frese M, Mevissen I, Harder A, Krieger K (2005) Effects of a combinations of emodepside and praziquantel on parasites of reptiles and rodents. Parasitol Res 97(Suppl 1):S65–S69
Mehlhorn H (ed) (2016) Encyclopedia of parasitology, 4th edn. Springer, Berlin, Heidelberg
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Mehlhorn, H. (2021). Praziquantel: An Efficacious Pharmaceutical Compound to Treat Human and Animal Infections Due to Trematodes and Cestodes. In: Petney, T.N., Saijuntha, W., Mehlhorn, H. (eds) Biodiversity of Southeast Asian Parasites and Vectors causing Human Disease. Parasitology Research Monographs, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-030-71161-0_10
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