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The efficacy of praziquantel against cestodes in animals

  • Praziquantel-Data On The Efficacy Against Schistosoma Mansoni, S. Haematobium, And S. Japonicum In Experimentally Infected Animals
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Summary

Praziquantel (EMBAY 8440, Droncit®) is a new type of acylated isoquinoline-pyrazine. A single oral or subcutaneous dose of the compound is reliably effective against juvenile and adult cestodes in mice and rats.

For the first time, with praziquantel a compound is available that is also effective on cestodes in the bile-duct.

Using Hymenolepis nana in mice we were able to show that age, sex, strain and intensity of infestation of the host have no influence on the efficacy.

The onset of the effect of praziquantel in vivo is rapid. Within 10 min the parasites were immobilized and contracted and excreted within a few hours with the faeces.

Zusammenfassung

Praziquantel (EMBAY 8440, Droncit®) ist ein neuer Typ eines acylierten Pyrazino-isochinolin. Eine einmalige orale oder subkutane Gabe ist zuverlässig wirksam gegen jugendliche und adulte Cestoden in Mäusen und Ratten.

Mit Praziquantel steht erstmals ein Mittel zur Verfügung, das auch gegen Gallengang-Cestoden wirksam ist.

In Versuchen mit Hymenolepis nana in Mäusen konnte gezeigt werden, daß Alter, Geschlecht, Stamm und Infektionsstärke des Wirtes die Wirksamkeit von Praziquantel nicht beeinflussen.

Die Wirkung von Praziquantel auf den Parasiten tritt in vivo sehr schnell ein. Innerhalb von 10 min sind die Parasiten bewegungslos und kontrahiert und werden innerhalb weniger Stunden mit den Faeces ausgeschieden.

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References

  • Andrews, P.: Pharmacokinetic studies with Droncit® in animals using a biological assay. Vet.-med. Nachr. 2, 154–165 (1976)

    Google Scholar 

  • Baldock, F.C., Flucke, W.J., Hopkins, T.J.: Efficiency of Droncit®, a new cestocide, against Taenia hydatigena in the dog. (not yet published)

  • Bankov, D.: Efficacy of praziquantel against Stilesia globipunctata and other cestodes in sheep. 7th Int. Conf. on Pathophysiol. of Parasit. Infections, Thessaloniki (1975)

  • Boray, J.C., v. Orelli, M., Sarasin, G.: Cantrodifene, a broad spectrum anthelmintic for dogs. Proc. 3rd Int. Congr. Parasit., München 3, 1353–1355 (1974)

    Google Scholar 

  • Burrows, R.B., Lillis, W.G.: Treatment of canine and feline tapeworm infections with bunamidine hydrochloride. Amer. J. vet. Res. 27, 1381–1384 (1966)

    Google Scholar 

  • Cook, R.B.: A field trial with bunamidine hydrochloride as an anthelmintic in the eradication of Echinococcus granulosus, Taenia hydatigena and Taenia ovis in New Zealand. N.Z. vet. J. 18, 152–155 (1970)

    PubMed  Google Scholar 

  • Cordero del Campillo, M., Diez Banos, P., Santo Tomas, J.R., Rojo Vazquez, J.: La efficacia de Droncit® contra Echinococcus granulosus juveniles en perros experimentalmente infectados. (not yet published)

  • Cox, D.D.: Preliminary tolerance and efficacy evaluations of technical Droncit in dogs. (not yet published)

  • Cox, D.D., Müller, M.T., Allen, A.D.: The anthelmintic activity of Yomesan against Taenia spp. of dogs and cats. Vet. med. Rev. 1, 49–55 (1966)

    Google Scholar 

  • Dey-Hazra, A.: Die Wirkung von Droncit® auf Bandwurminfektionen bei Hund und Katze. Vet.-med. Nachr. 2, 134–141 (1976)

    Google Scholar 

  • Diekmann, H.W., Andrews, P., v. Eberstein, M., Frohberg, H., Gröning, P., Mürmann, P.: Toxicological, pharmacological and pharmacokinetic studies with a new cestocide. 7th Int. Conf. on Pathophysiol. of Parasit. Infections, Thessaloniki (1975a). 2nd Europ. Multicolloquy of Parasit., Trogir (1975b)

  • Diekmann, H.W., Bühring, K.U.: The fate of praziquantel in the organism. III. Metabolism in rat, beagle dog and rhesus monkey. Europ. J. Drug Metabol. Pharmacokinet. 2, 107–112 (1976)

    Google Scholar 

  • Forbes, L.S.: The efficiency of bunamidine hydrochloride against young Echinococcus granulosus infection in dogs. Vet. Rec. 79, 306–307 (1966)

    PubMed  Google Scholar 

  • Gemmell, M.A., Johnstone, P.D., Oudemans, G.: The effect of praziquantel (Droncit®) on Echinococcus granulosus, Taenia hydatigena and Taenia ovis in dogs. Res. Vet. Sci. in press (1977)

  • Gemmell, M.A., Shearer, G.G.: Bunamidine hydrochloride. Its efficiency against Echinococcus granulosus. Vet. Rec. 82, 252–256 (1968)

    Google Scholar 

  • Gönnert, R., Andrews, P.: Praziquantel, a new broad-spectrum antischistosomal agent. Z. Parasitenk. 52, 129–150 (1977)

    PubMed  Google Scholar 

  • Gönnert, R., Schraufstätter, E.: Experimentelle Untersuchungen mit N-(2′-Chlor-4′-nitrophenyl)-5-chlorsalicylamid, einem neuen Bandwurmmittel. Arzneimittelforsch. 10, 881–885 (1960)

    PubMed  Google Scholar 

  • Güralp, N., Tiğin, Y., Oğuz, T., Tinar, R., Burgu, A.: Vorläufige Untersuchungen über die Wirksamkeit von Droncit® gegen verschiedene Bandwurmarten bei Hunden und Katzen. Vet.-med. Nachr. 2, 129–133 (1976)

    Google Scholar 

  • Hall, C.K.: Mansonil, a new cestocide for sheep. Vet. med. Rev. 1, 59–66 (1966)

    Google Scholar 

  • Hatton, C.J.: A new taeniacide, bunamidine hydrochloride. Its efficiency against Taenia pisiformis and Dipylidium caninum in the dog and Hydatigera taeniaeformis in the cat. Vet. Rec. 77, 408–411 (1965)

    PubMed  Google Scholar 

  • Hatton, C.J.: Efficiency of bunamidine salts against tapeworms. Vet. Rec. 81, 104–106 (1967)

    PubMed  Google Scholar 

  • James, C., Webbe, G., Nelson, G.S.: The susceptibility to praziquantel of Schistosoma haematobium in the baboon and of S. japonicum in the vervet monkey. Z. Parasitenk. 52, 179–195 (1977)

    PubMed  Google Scholar 

  • Katiyar, R.D., Garo, R.K.: Anthelmintic efficacy of Yomesan against tapeworms in sheep. Ind. vet. J. 43, 310 (1966)

    Google Scholar 

  • Leopold, G., Diekmann, H., Nowak, H., Patzschke, K.: Pharmakokinetik von Praziquantel. Vortrag: Tagung der deutschspr. Tropenmed, Gesellschaften, Lindau 1977

  • Most, H., Yoeli, M., Hammond, J., Scheinesson, G.Z.: Yomesan (niclosamide) therapy of Hymenolepis nana infections. Amer. J. trop. Med. Hyg. 20, 206–208 (1971)

    Google Scholar 

  • Mürmann, P., v. Eberstein, M., Frohberg, H.: Zur Verträglichkeit von Droncit®. Vet.-med. Nachr. 2, 142–153 (1976)

    Google Scholar 

  • Pellegrino, J., Lima-Costa, F.F., Carlos, M.A., Mello, R.T.: Experimental chemotherapy of Schistosomiasis mansoni. XIII. Activity of praziquantel, an isoquinoline-pyrazino derivative, on mice, hamsters and Cebus monkeys, Z. Parasitenk. 52, 151–168 (1977)

    PubMed  Google Scholar 

  • Perera, D.R., Western, K.A., Schultz, M.G.: Niclosamide treatment of cestodiasis. Amer. J. trop. Med. Hyg. 19, 610–612 (1970)

    Google Scholar 

  • Pfeiffer, H.: Zur Wirkung von Mansonil gegen Moniezia-Befall der Rinder. Wien. tierärztl. Mschr. 52, 910–912 (1965)

    Google Scholar 

  • Poole, J.B., Dooley, K.L., Rollins, L.D.: Efficacy of niclosamide for the removal of tapeworms (Dipylidium caninum and Taenia pisiformis) from dogs. J. Amer. vet. med. Ass. 159, 78–80 (1971)

    PubMed  Google Scholar 

  • Rommel, M., Grelck, H., Hörchner, F.: Zur Wirksamkeit von praziquantel gegen Bandwürmer in experimentell infizierten Hunden und Katzen. Berl. Münch. tierärztl. Wschr. 89, 255–257 (1976)

    Google Scholar 

  • Sakamoto, T.: The anthelmintic effect of Droncit® on adult tapeworms of Hydatigera taeniaeformis, Mesocestoides corti and Diphyllobothrium erinacei. Vet.-med. Nachr. (in press 1977)

  • Steiner, K., Garbe, A.: The fate of praziquantel in the organism. II. Distribution in rats. Europ. J. Drug Metabol. Pharmacokinet. 2, 97–106 (1976b)

    Google Scholar 

  • Steiner, K., Garbe, A., Diekmann, H., Nowak, H.: the fate of Praziquantel in the organism. Europ. J. Drug Metabol. Pharmacokinet. 2, 85–95 (1976a)

    Google Scholar 

  • Thomas, H., Andrews, P.: Praziquantel, a new cestocide. Pest. Sci. (in press 1977)

  • Thomas, H., Gönnert, R.: The efficacy of Droncit® against cestodes in cats, dogs and sheep. Res. Vet. Sci. (in press 1977)

  • Thomas, H., Gönnert, R., Pohlke, R., Seubert, J.: Investigations about treatment of larval cestodes. 7th Int. Conf. on Pathophysiol. of Parasit. Infections, Thessaloniki (1975a)

  • Thomas, H., Gönnert, R., Pohlke, R., Seubert, J.: A new compound against adult tapeworms. 7th Int. Conf. on Pathophysiol. of Parasit. Infections, Thessaloniki (1975b)

  • Thomas, H., Gönnert, R., Pohlke, R., Seubert, J.: Experimental and clinical studies with a new compound against tapeworms. 2nd Europ. Multicolloquy of Parasit., Trogir (1975c)

  • Thomas, H., Gönnert, R., Pohlke, R., Seubert, J.: Experiences with a new compound against larval cestodes. 2nd Europ. Multicolloquy of Parasit., Trogir (1975d)

  • Webbe, G., James, C.: A comparison of the susceptibility of praziquantel of Schistosoma haematobium, S. japonicum, S. mansoni, S. intercalatum and S. mattheei in hamsters. Z. Parasitenk, 52, 169–177 (1977)

    PubMed  Google Scholar 

  • Wescott, R.B.: Efficacy of niclosamide in the treatment of Taenia taeniaeformis infections in cats. Amer. J. vet. Res. 28, 1475–1477 (1967)

    PubMed  Google Scholar 

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  1. Institute of Chemotherapy, Bayer AG, D-5600, Wuppertal-1, Federal Republic of Germany

    H. Thomas & R. Gönnert

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  1. H. Thomas
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  2. R. Gönnert
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Thomas, H., Gönnert, R. The efficacy of praziquantel against cestodes in animals. Z. F. Parasitenkunde 52, 117–127 (1977). https://doi.org/10.1007/BF00389898

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  • DOI: https://doi.org/10.1007/BF00389898

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