Abstract
Liver disease, regardless of etiology, shares a similar natural history of disease progress and is common worldwide. This spectrum of diseases progresses from simple steatosis (fat accumulation), to inflammation, and eventually to fibrosis and cirrhosis. Hepatic fibrosis is primarily characterized by robust accumulation of collagen ECM that leads to organ dysfunction and decompensation. The role of the ECM in early stages of chronic liver disease is less well-understood, but recent studies have demonstrated that a number of changes in the hepatic ECM in early-stage liver disease may also contribute to disease progression. The purpose of this review is to summarize the established and proposed changes to the hepatic extracellular matrix (ECM) that may contribute to inflammation during earlier stages of disease development, and to discuss potential mechanisms by which these changes may mediate the progression of the disease.
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Dolin, C.E., Sato, T., Merchant, M.L., Arteel, G.E. (2020). Detecting Changes to the Extracellular Matrix in Liver Diseases. In: Ricard-Blum, S. (eds) Extracellular Matrix Omics. Biology of Extracellular Matrix, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-030-58330-9_3
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