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Anticancer Activity of Secondary Metabolites of Teucrium Species

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Teucrium Species: Biology and Applications

Abstract

Cancer is one of the life-threatening diseases and currently leading human health problem. Conventional use of chemotherapeutics in anticancer therapy is faced with some problems, such as their being harmful for the organism and development of the cancer cell resistance to the current therapeutic agents. There is a great need to discover and develop new anticancer drugs, more effective and less toxic for healthy cells, such as plant-derived compounds. There is a variety of experimental and epidemiological evidence that plant extracts and secondary metabolites from them achieve anticancer activity. Many of the species from the genus Teucrium have been used extensively in the traditional medicine as medicinal plants for treatment of numerous diseases, due to a variety of their therapeutic properties. Bearing in mind the advantages of utilization of plant products as anticancer agents, we revised recent literature and searched bibliographic databases about anticancer properties of Teucrium species, with an aim to give survey of their investigation and emphasize the need for further research in order to improve the anticancer treatment. This paper presents an overview of the current in vitro and in vivo data that support their anticancer potential. The extracts of Teucrium species and their secondary metabolites showed antiproliferative effects on multiple cancer cell lines, multiple signaling pathways, and altered the expression of genes and proteins involved in cancer development, cell cycle, apoptosis, angiogenesis, metastasis. The comparative review of results may contribute to better understanding of possible mechanisms of action and stimulate further examination for application of Teucrium species as adjuvant chemotherapeutics.

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Abbreviations

AO/EB:

Acridine Orange/Ethidium Bromide

Bcl-2:

B-cell lymphoma 2

Bid:

BH3 interacting-domain death agonist

Cdks:

Cyclins dependent kinases

CKIs:

Cdk inhibitors

CLL:

Chronic Lymphocytic Leukemia

CXCL-12:

CXC Motif Chemokine Ligand 12

CXCR-4:

CXC Receptor 4

DISC:

Death-Inducing-Signaling Complex

ECM:

Extracellular Matrix

EMT:

Mesenchymal-epithelial Transition

FGF:

Fibroblast Growth Factor

GSH:

Glutathione

HIF-1α:

Hypoxia Inducible Factor-1α

ICAM-1:

Intracellular Adhesion Molecule

iNOS:

Inducible Nitric Oxide Synthase

MMP:

Matrix metalloproteinase

MTT:

3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide

NCI:

National Cancer Institute

O2.- :

Superoxide anion radical

PARP:

Poly ADB Ribose Polymerase

PI:

Propidium Iodide

RNS:

Reactive Nitrogen Species

ROS:

Reactive Oxygen Species

Smac/DIABLO:

Second mitochondria-derived activator of caspase/Direct Inhibitor of Apoptosis-Binding protein

STAT3:

Signal Transducer and Activator of Transcription 3

tBid:

Truncated Bid

TNF:

Tumor Necrosis Factor

VCAM1:

Vascular Cell Adhesion Molecule 1

VEGF:

Vascular Endothelial Growth Factor

XIAP:

Inhibitor of caspase function proteins

γ-GCS:

γ-glutamyl cysteine synthetase

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Acknowledgments

This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Grant III41010).

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    Milena Milutinović & Danijela Cvetković

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    Milan Stanković

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Milutinović, M., Cvetković, D. (2020). Anticancer Activity of Secondary Metabolites of Teucrium Species. In: Stanković, M. (eds) Teucrium Species: Biology and Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-52159-2_13

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