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Toxicity Assessment of Nanomaterials

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Magnetic Nanoheterostructures

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

Abstract

In the last decades, nanoscience had a spectacular evolution providing new, versatile engineered nanomaterials and nanotools with a plethora of applications in very diverse fields ranging from energy storage to medicine. Among the palette of nanomaterials, magnetic nanoparticles (in particular iron oxide-based) present unique physicochemical properties that are actively being exploited in the biomedical field. Currently, they are used for induced magnetic hyperthermia cancer treatments, as contrast agents for magnetic resonance imaging, as cell tracking elements, and for drug delivery modalities. In parallel to the growth of nanoscience and the ever-increasing applications of nanomaterials, concerns regarding the safety and toxicity of nanoparticles have arisen, both during and post-administration. In this chapter, we review key concepts related to nanotoxicology and to the fate of nanomaterials in the human body. A detailed description about the most accepted and practiced in vitro and in vivo methods used to evaluate the toxicity of nanomaterials is provided, with emphasis in magnetic nanomaterials for nanomedicine applications.

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Acknowledgements

A.S.P. and M.T. thank INIFTA, UNLP, and CONICET for their support. A.S.P and M.T. are CONICET fellows.

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Authors and Affiliations

  1. Departamento de Química, Facultad de Ciencias Exactas, Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Universidad Nacional de La Plata—CONICET, Diagonal 113 y 64, 1900, La Plata, Argentina

    Mariana Tasso & Agustin S. Picco

  2. Instituto de Nanosistemas, Universidad Nacional de San Martín, 25 de mayo 1021, 1650, Villa Lynch, Argentina

    Maria Amparo Lago Huvelle & Ines Diaz Bessone

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  1. Mariana Tasso
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  2. Maria Amparo Lago Huvelle
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  3. Ines Diaz Bessone
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  4. Agustin S. Picco
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Correspondence to Agustin S. Picco .

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  1. Department of Physics, Faculty of Science and Technology, The University of the West Indies, St. Augustine, Brazil

    Surender Kumar Sharma

  2. Department of Physics, University of Agriculture Faisalabad, Faisalabad, Pakistan

    Yasir Javed

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Tasso, M., Lago Huvelle, M.A., Diaz Bessone, I., Picco, A.S. (2020). Toxicity Assessment of Nanomaterials. In: Sharma, S., Javed, Y. (eds) Magnetic Nanoheterostructures. Nanomedicine and Nanotoxicology. Springer, Cham. https://doi.org/10.1007/978-3-030-39923-8_13

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