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Global Transcriptional Regulators Involved in Carbon, Nitrogen, Phosphorus, and Sulfur Metabolisms in Corynebacterium glutamicum

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Corynebacterium glutamicum

Part of the book series: Microbiology Monographs ((MICROMONO,volume 23))

Abstract

Bacteria are equipped with sophisticated metabolic control systems to adapt to variable nutrient conditions. While metabolic pathways are controlled at enzyme activity levels and at mRNA levels, scarcity in preferred nutrients causes transcriptional induction of genes for alternative nutrient source utilization. Transcriptional regulatory systems controlling metabolisms of carbon, nitrogen, phosphate, and sulfur in Corynebacterium glutamicum have been extensively studied for the last two decades. The knowledge of the regulators, including regulon members, operator sequences, and effectors, has deepened our understanding of the C. glutamicum physiology and has led to develop synthetic biology tools for metabolic engineering, maximizing the C. glutamicum potential as a production host. In this chapter, we review the studies of the transcriptional regulators, especially focus on those with global regulatory roles in the primary metabolism in C. glutamicum.

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Authors and Affiliations

  1. Research Institute of Innovative Technology for the Earth (RITE), Kyoto, Japan

    Koichi Toyoda & Masayuki Inui

  2. Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan

    Masayuki Inui

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  1. Koichi Toyoda
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  2. Masayuki Inui
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Correspondence to Masayuki Inui .

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  1. Molecular Microbiology and Biotechnology, Research Institute of Innovative Technology, Kyoto, Japan

    Masayuki Inui

  2. Molecular Microbiology and Biotechnology, Research Institute of Innovative Technology, Kyoto, Japan

    Koichi Toyoda

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Toyoda, K., Inui, M. (2020). Global Transcriptional Regulators Involved in Carbon, Nitrogen, Phosphorus, and Sulfur Metabolisms in Corynebacterium glutamicum . In: Inui, M., Toyoda, K. (eds) Corynebacterium glutamicum. Microbiology Monographs, vol 23. Springer, Cham. https://doi.org/10.1007/978-3-030-39267-3_5

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