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Adipose Tumor Microenvironment

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Tumor Microenvironments in Organs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1226))

Abstract

The term “adipose tissue” represents a multicellular and multifunctional organ involved in lipid storage, in hormone and temperature regulation, and in the protection of bones and vital organs from impact-based damage. Emerging evidence now suggests a more malignant role of adipose tissue in promoting cancer onset and progression via the release of secreted factors such as interleukin-6 (IL6) and extracellular vesicles (EVs). These adipose-source factors subsequently affect various aspects of tumorigenesis and/or cancer progression by either directly enhancing the tumor cell oncogenic phenotype or indirectly by the stimulating adjacent normal cells to adopt a more pro-cancer phenotype. Due to the recent growing interest in the role of IL6 and EVs released by adipose tissue in cancer promotion and progression, we are focusing on the protumorigenic impact of fat tissue via IL6 and EV secretion.

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Authors and Affiliations

  1. Program in Translational Therapeutics, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

    Abbie Zewdu, Lucia Casadei, Raphael E. Pollock & Danielle Braggio

  2. Department of Surgery, The Ohio State University, Columbus, OH, USA

    Abbie Zewdu, Lucia Casadei, Raphael E. Pollock & Danielle Braggio

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  1. Abbie Zewdu
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  2. Lucia Casadei
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  3. Raphael E. Pollock
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  4. Danielle Braggio
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Correspondence to Lucia Casadei .

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Editors and Affiliations

  1. Columbia University Medical Center, Department of Radiology, New York, NY, USA, Federal University of Minas Gerais, Department of Pathology, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Zewdu, A., Casadei, L., Pollock, R.E., Braggio, D. (2020). Adipose Tumor Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironments in Organs. Advances in Experimental Medicine and Biology, vol 1226. Springer, Cham. https://doi.org/10.1007/978-3-030-36214-0_6

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