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The Roles of Bone Marrow-Resident Cells as a Microenvironment for Bone Metastasis

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Tumor Microenvironments in Organs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1226))

Abstract

It has been appreciated that the cross talk between bone metastatic cancer cells and bone marrow microenvironment influence one another to worsen bone metastatic disease progression. Bone marrow contains various cell types, including (1) cells of mesenchymal origin (e.g., osteoblasts, osteocytes, and adipocytes), (2) cells of hematopoietic origin (e.g., osteoclast and immune cells), and (3) others (e.g., endothelial cells and nerves). The recent studies have enabled us to discover many important cancer-derived factors responsible for the development of bone metastasis. However, many critical questions regarding the roles of bone microenvironment in bone metastatic progression remain elusive. To answer these questions, a deeper understanding of the cross talk between bone metastatic cancer and bone marrow microenvironment is clearly warranted.

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Acknowledgments

This work is directly supported by Department of Defense (W81XWH-14-1-0403; W81XWH-17-1-0541; and W81XWH-19-1-0045) and the Wake Forest Baptist Comprehensive Cancer Center Internal Pilot Funding. This work is also supported by the National Cancer Institute’s Cancer Center Support Grant award number P30CA012197 issued to the Wake Forest Baptist Comprehensive Cancer Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute.

Conflict of Interests: The authors declare that they have no conflict of interests.

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  1. Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC, USA

    Yusuke Shiozawa

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  1. Yusuke Shiozawa
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Correspondence to Yusuke Shiozawa .

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  1. Columbia University Medical Center, Department of Radiology, New York, NY, USA, Federal University of Minas Gerais, Department of Pathology, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Shiozawa, Y. (2020). The Roles of Bone Marrow-Resident Cells as a Microenvironment for Bone Metastasis. In: Birbrair, A. (eds) Tumor Microenvironments in Organs. Advances in Experimental Medicine and Biology, vol 1226. Springer, Cham. https://doi.org/10.1007/978-3-030-36214-0_5

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