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Neutrophilic and Pustular Eruptions

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Hospital-Based Dermatopathology

Abstract

This chapter reviews noninfectious inflammatory dermatoses with mainly neutrophilic infiltrates and the formation of pustules. The infiltrate containing neutrophils may be either mild as in urticaria or very dense, even with leukocytoclasia as in Sweet syndrome or pyoderma gangrenosum. Neutrophilic infiltrates and pustular eruptions are caused by different noninfectious immunomechanisms. For some of them, mutations have been found (e.g., NLRC4 mutation in cryopyrin-associated periodic syndromes (CAPS) leading to activation of the inflammasome; IL36RN mutation in pustular psoriasis resulting in uncontrolled IL36-signaling). Neutrophilic dermatoses are of high interest, as they may present dermatological reaction patterns of underlying benign or malignant conditions.

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Authors and Affiliations

  1. Unit of Dermatopathology, Department of Dermatology, Technical University of Munich, School of Medicine, Munich, Germany

    Sigrid M. C. Möckel

  2. Department of Dermatology, University Hospital Münster, Münster, Germany

    Dieter Metze

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  1. Sigrid M. C. Möckel
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Correspondence to Sigrid M. C. Möckel .

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Editors and Affiliations

  1. Professor of Pathology, Harvard Medical School, Director of Dermatopathology, Massachusetts General Hospital, Boston, MA, USA

    Mai P. Hoang

  2. Professor of Pathology and Dermatology, Director, Dermatopathology Unit, Duke University Medical Center, Durham, NC, USA

    Maria Angelica Selim

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Möckel, S.M.C., Metze, D. (2020). Neutrophilic and Pustular Eruptions. In: Hoang, M., Selim, M. (eds) Hospital-Based Dermatopathology. Springer, Cham. https://doi.org/10.1007/978-3-030-35820-4_4

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