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Hyaluronan Oligosaccharides Promote Wound Repair

Its Size-Dependent Regulation of Angiogenesis

  • Chapter
The New Angiotherapy

Abstract

Hyaluronan (HA, previously called hyaluronic acid or hyaluronate) is a high-molecular weight linear polysaccharide, a member of the glycosaminoglycan family, composed of repeating 1,4- linked disaccharide units of 1,3- linked glucuronic acid and N-acetylglucosamine (Fig.1). It is present in the extracellular matrix of most animal tissues, occurring at greatest concentration in adult connective tissues. Several factors, including its ubiquitous distribution, the high concentration in cartilage and synovial fluid, the capacity to bind large amounts of water, and its simple structure, led to the general belief that its function was essentially that of an inert viscoelastic lubricant, or space-filling molecule (1,2). Furthermore, its viscoelastic properties, chemical simplicity, and lack of immunogenicity have made it the basis for biomaterials used in viscosurgery, tissue engineering, and drug delivery systems (3). However, in recent years, a growing number of reports have appeared indicating that HA has profound effects on the behavior of various cell-types, apparently mediated by several surface receptors (4,5).

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Authors
  1. David C. West
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  2. Tai-Ping D. Fan
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Editors and Affiliations

  1. Angiogenesis Laboratory, Department of Pharmacology, University of Cambridge, Cambridge, UK

    Tai-Ping D. Fan PhD

  2. Molecular Signaling Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Elise C. Kohn MD (Chief) (Chief)

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West, D.C., Fan, TP.D. (2002). Hyaluronan Oligosaccharides Promote Wound Repair. In: Fan, TP.D., Kohn, E.C. (eds) The New Angiotherapy. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-126-8_11

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  • DOI: https://doi.org/10.1007/978-1-59259-126-8_11

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