The New Angiotherapy

  • Tai-Ping D. Fan
  • Elise C. Kohn

Table of contents

  1. Front Matter
    Pages i-xix
  2. Concepts

    1. Front Matter
      Pages N1-N1
    2. Robert Auerbach, Wanda Auerbach
      Pages 1-6
    3. Michael S. Pepper, Stefano J. Mandriota, Roberto Montesano
      Pages 7-40
    4. Pamela F. Jones
      Pages 41-50
    5. Amy D. Bradshaw, E. Helene Sage
      Pages 51-66
  3. Angiogenesis in Health and Disease

    1. Front Matter
      Pages N3-N3
    2. Dorothy Rodriguez, Peter C. Brooks
      Pages 67-79
    3. David Andrew Walsh, Tai-Ping D. Fan
      Pages 81-104
    4. Wayne A. Morrison, Geraldine M. Mitchell, Jane E. Barker, Tamara Konopka, Alastair G. Stewart
      Pages 105-113
    5. D. Stephen Charnock-Jones, Yulong He, Stephen K. Smith
      Pages 115-128
    6. Ewa M. Paleolog, Jadwiga M. Miotla
      Pages 129-149
    7. Stephen B. Fox, Adrian L. Harris
      Pages 151-176
  4. Stimulation of Angiogenesis [Therapeutic Angiogenesis]

    1. Front Matter
      Pages N5-N5
    2. David C. West, Tai-Ping D. Fan
      Pages 177-188
    3. Hynda K. Kleinman, Derrick S. Grant, Katherine M. Malinda
      Pages 189-197
    4. Sandor Szabo, Yuen Shing, M. Judah Folkman, Aron Vincze, Zoltan Gombos, Xiaoming Deng et al.
      Pages 199-211
    5. Margaret D. Brown, Olga Hudlická
      Pages 213-248
    6. Jeffrey M. Isner, Takayuki Asahara
      Pages 249-277
    7. Johannes Waltenberger, Vinzenz Hombach
      Pages 279-293

About this book

Introduction

Angiogenesis, the development of new blood vessels from an existing vascular bed, is an essential feature in many pathological conditions, including cancer, atherosclerosis, rheumatoid arthritis, and diabetic neuropathy. Inadequate regulation of angiogenesis can often lead to chronic pressure ulcers, duodenal ulcers, and myocardial infarction. In The New Angiotherapy, an international team of experts critically review the recent progress in both basic and applied research on angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel angiotherapeutic targets and their use in the clinic. Details of fundamental concepts in angiogenesis physiology and pathophysiology are provided, and the potential of angiotherapy in the management of angiogenic disease is evaluated, highlighting some of the angiogenic and antiangiogenic agents both in development and in clinical trials. The future prospects of receptor antagonists, enzyme inhibitors, and vascular targeted approaches, especially gene therapy in the development of angiotherapy, are also covered.
Authoritative and cutting-edge, The New Angiotherapy illuminates our understanding of the central role of human angiogenesis, as well as the novel therapeutic approaches now made possible by our ability to control vascular development.

Keywords

cardiovascular endothelium pathophysiology physiology surgery tissue

Editors and affiliations

  • Tai-Ping D. Fan
    • 1
  • Elise C. Kohn
    • 2
  1. 1.Angiogenesis Laboratory, Department of PharmacologyUniversity of CambridgeCambridgeUK
  2. 2.Molecular Signaling Section, Laboratory of Pathology, National Cancer InstituteNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-126-8
  • Copyright Information Humana Press 2002
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-9657-4
  • Online ISBN 978-1-59259-126-8
  • About this book