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Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

Sporotrichosis is a chronic disease caused by a soil fungus, Sporothrix schenckii. Typically, the disease produces suppurating nodules along the lymphatics of the skin and subcutaneous tissues with new lesions forming proximally as the older distal lesions heal slowly. Rarely, the process extends directly or via the blood stream beyond the skin to deeper structures, especially bone and synovial tissues. Lesions occur in other organs even less frequently.

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References

  1. Rippon, J. W. (ed.), 1988, Sporotrichosis, in: Medical Mycology. The Pathogenic Fungi and the Pathogenic Actinomycetes, 3rd ed., W. B. Saunders, Company, Philadelphia, pp. 325–352.

    Google Scholar 

  2. Arango, C., Davila, E., and Greenma, R., 1981, Multifocal sporotrichosis presenting with lobar pulmonary consolidation, South Med. J. 74: 755–756.

    Article  PubMed  CAS  Google Scholar 

  3. Kinas, H. Y., and Smulewicz, J. J., 1976, Primary pulmonary sporotrichosis, Respiration 33: 468–474.

    Article  PubMed  CAS  Google Scholar 

  4. Rohatgi, P. K., 1980, Pulmonary sporotrichosis, South Med. J. 73: 1611–1617.

    Article  PubMed  CAS  Google Scholar 

  5. Zvetina, J. R., Rippon, J. W, and Daum, V., 1978, Chronic pulmonary sporotrichosis, Mycopathologia 64: 53–57.

    Article  PubMed  CAS  Google Scholar 

  6. Scott, E. N., Kaufman, L., Brown, A. C., and Muchmore, H. G., 1987, Serologic studies in the diagnosis and management of meningitis due to Sporothrix schenckii, N. Engl. J. Med. 317: 935–940.

    Article  PubMed  CAS  Google Scholar 

  7. Dellatorre, D. L., Lattanand, A., Buckley, H. R., Urbach, E, 1982, Fixed cutaneous sporotrichosis of the face, Successful treatment of a case. Review of the literature, J. Am. Acad. Dermatol. 6: 97–100.

    Article  PubMed  CAS  Google Scholar 

  8. Honbo, S., Yamano, T., Masaki, J., and Urabe, H., 1985, Analytical studies on peculiar cases of sporotrichosis, the lesions of which contained numerous fungal elements, Proc. IXth. Congr. Int. Soc. Human Anim. Mycol. R11–12.

    Google Scholar 

  9. Kwon-Chung, K. J., 1979, Comparison of isolates of Sporothrix schenckii obtained from fixed cutaneous lesions with isolates from other types of lesions, J. Inf. Dis. 139: 424–431.

    Article  CAS  Google Scholar 

  10. MacKinnon, J. E., and Conti-Diaz, I. A., 1962, The effect of temperature on sporotrichosis, Sabouraudia 2: 56–59.

    Article  Google Scholar 

  11. Iwatsu, T., Nishmura, K., and Miyaji, M., 1985, Spontaneous disappearance of cutaneous sporotrichosis, Int. J. Dermatol. 24: 524–525.

    PubMed  CAS  Google Scholar 

  12. Pueringer, R. J., Iber, D., Deike, M. A., and Davies, S. E, 1986, Spontaneous remission of extensive pulmonary sporotrichosis, Ann. Intern. Med. 104: 366–367.

    Article  PubMed  CAS  Google Scholar 

  13. Pluss, J. L., and Opal, S. M., 1986, Pulmonary sporotrichosis: Review of treatment and outcome, Medicine 65: 143–152.

    Article  PubMed  CAS  Google Scholar 

  14. Michelson, E., 1977, Primary pulmonary sporotrichosis, Ann. Thorac. Surg. 24: 83–86.

    Article  PubMed  CAS  Google Scholar 

  15. Ridgeway, N. A., Whitcomb, R. C., Erickson, E. E., and Law, S. W, 1962, Primary pulmonary sporotrichosis, Am. j Med. 32: 153–160.

    Article  PubMed  CAS  Google Scholar 

  16. Smith, L. M., 1945, Sporotrichosis. Report of four clinically atypical cases, South Med. J. 38: 504–509.

    Google Scholar 

  17. Winn, R. E., 1988, Sporotrichosis, in: Systemic Fungal Infections: Diagnosis and Treatment I. Infectious Disease Clinics of North America, Volume 2, ( D. J. Drutz, ed.), W. B. Saunders, Co., Philadelphia, pp. 899–911.

    Google Scholar 

  18. Mohr, J. A., Patterson, C. D., Eaton, B. G., Rhoades, E. R., and Nichols, N. B., 1972, Primary pulmonary sporotrichosis, Am. Rev. Respir. Dis. 106: 260–264.

    PubMed  CAS  Google Scholar 

  19. Mariat, E, 1977, Taxonomic problems related to the fungal complex Sporothrix schenckii/ Ceratocystis spp., in: Recent Advances in Medical and Veterinary Mycology ( K. Iwata, ed.), University of Tokyo Press, Tokyo, pp. 265–270.

    Google Scholar 

  20. Shadomy, H. J., and Davis, B. A., 1989, The teleomorphic state of Sporothrix schenckii, Proc. Xth. Congr. Int. Soc. Human Anim. Mycol., Abstr #P-55, p. 64.

    Google Scholar 

  21. Simson, E. W, 1947, Sporotrichosis infection in mines of the Witwatersrand. A symposium, Proc. Transv. Mine Med. Officers Assoc. pp. 1–67.

    Google Scholar 

  22. CDC, 1988, Multistate outbreak of sporotrichosis in seedling handlers, M.M.W.R. 37: 652–653.

    Google Scholar 

  23. D’Alessio, D. J., Leavens, L. J., Strumpf, G. B., and Smith, C. D., 1965, An outbreak of sporotrichosis in Vermont associated with sphagnum moss as the source of infection, N. Engl. J. Med. 272: 1054–1058.

    Article  Google Scholar 

  24. Powell, K. E., Taylor, A., Phillips, B. J., Blakey, D. L., Campbell, G. D., Kaufman, L., and Kaplan, W, 1978, Cutaneous sporotrichosis in forestry workers, A.M.A. 240: 232–235.

    Article  CAS  Google Scholar 

  25. Ingrish, E M., and Schneidau, J. D., 1967, Cutaneous hypersensitivity to sporotrichin in Maricopa County, Arizona, J. Invest. Dermatol. 49: 146–149.

    Google Scholar 

  26. Schneidau, J. D., Lamar, L. M., and Hairston, M. A., 1964, Cutaneous hypersensitivity to sporotrichin in Louisiana, J.A.M.A. 188: 371–373.

    Article  PubMed  Google Scholar 

  27. Gonzalez-Ochoa, A., 1965, Contribuciones recientes al conociemiento de la esporotrichosis, Gac. Med. Mex. 95: 463–474.

    Google Scholar 

  28. Gonzalez-Ochoa, A., Ricoy, E., 1970, Valoracion comparatira de los antigenos polisacarido y cellular de Sporothrix schenckii, Rev. Invest. Salud. Publica. 30: 303–315.

    PubMed  CAS  Google Scholar 

  29. Rocha-Posada, H., 1968, Prueba cutanea con esporotricina, Mycopathologia 36: 42–54.

    Google Scholar 

  30. Scott, E. N., Muchmore, H. G., and Parkinson, A. J., 1982, Enzyme and radio immunoassays in human sporotrichosis, Proc. VIIIth. Congr. Int. Soc. Human Anim. Mycol., pp. 212–215.

    Google Scholar 

  31. Mariat, E, 1968, The epidemiology of sporotrichosis, in: Systemic Mycoses ( G. E. W. Wolstenholme, ed.), A. Churchill, London, pp. 144–159.

    Google Scholar 

  32. Kedes, L. H., Siemienski, J., and Braude, A. I., 1964, The syndrome of the alcoholic rose gardener: sporotrichosis of radial tendon sheath. Report of a case cured with amphotericin B, Ann. Intern. Med. 61: 1139–1141.

    Article  PubMed  CAS  Google Scholar 

  33. England, D. M., and Hochholzer, L., 1985, Primary pulmonary sporotrichosis: Report of eight cases with clinicopathologic review, Am. J. Surg. Pathol. 9: 193–203.

    Article  PubMed  CAS  Google Scholar 

  34. Jay, S. J., Platt, M. R., and Reynolds, R. C., 1977, Primary pulmonary sporotrichosis, Am. Rev. Respir. Dis. 115: 1051–1056.

    PubMed  CAS  Google Scholar 

  35. Bibler, M. R., Luber, H. J., Glueck, H. I., and Estes, S. A., 1986, Disseminated sporotrichosis in a patient with HIV infection after treatment for acquired factor VIII inhibitor, JA.M.A. 256: 3125–3126.

    Article  CAS  Google Scholar 

  36. Fitzpatrick, J. E., 1988, Acquired immunodeficiency syndrome presenting as disseminated cutaneous sporotrichosis, Int. J. Dermatol. 27: 406–407.

    Article  PubMed  CAS  Google Scholar 

  37. Kurosawa, A., 1988, Sporothrix schenckii endophthalmitis in a patient with human immunodeficiency virus infection, Arch. Ophthal. 106: 376–380.

    CAS  Google Scholar 

  38. Lipstein-Kresch, E., Isenberg, H. D., Singer, C., Cooke, O., and Greenwald, R. A., 1985, Disseminated Sporothrix schenckii infection with arthritis in a patient with acquired immunodeficiency syndrome, j Rheumatol. 12: 805–808.

    CAS  Google Scholar 

  39. Oda, L. M., Kubelka, C. E, Alviano, C. S., and Travassos, L. R., 1983, Ingestion of yeast forms of Sporothrix schenckii by mouse peritoneal macrophages, Infect. Immun. 39: 497–504.

    PubMed  CAS  Google Scholar 

  40. Alviano, C. S., Pereira, M. E. A., Souza, W, Oda, L. M., and Travassos, L. R., 1982, Sialic acids are surface components of Sporothrix schenckii yeast forms, FEMS Microbiol. Lett. 15: 223–227.

    Article  CAS  Google Scholar 

  41. Merrick, J. M., Zadarlik, K., and Milgrom, E, 1978, Characterization of the HanganutziuDeicher (serum sickness) antigen as gangliosides contain N-glycolylneuraminic acid, Intern. Arch. Allergy Appi. Immunol. 57: 477–480.

    Article  CAS  Google Scholar 

  42. Smith, D. E, and Ginsburg, V, 1980, Antibodies against sialyloligosaccharides coupled to protein, J. Biol. Chem. 255: 55–59.

    PubMed  CAS  Google Scholar 

  43. Warr, G. A., 1980, A macrophage receptor for (mannose/glucosamine) glycoproteins of potential importance in phagocytic activity, Biochem. Biophys. Res. Commun. 93: 737–745.

    Article  PubMed  CAS  Google Scholar 

  44. Cunningham, K. M., Bulmer, G. S., Rhoades, E. R., 1979, Phagocytosis and intracellular fate of Sporothrix schenckii, j Infect. Dis. 140: 815–817.

    Article  PubMed  CAS  Google Scholar 

  45. Lehrer, R. I., 1969, Antifungal effects of peroxidase systems, J. Bacteriol. 99: 361–365.

    PubMed  CAS  Google Scholar 

  46. Scott, E. N., Muchmore, H. G., and Fine, D. P., 1986, Activation of the alternative complement pathway by Sporothrix schenckii, Infect. Immun. 51: 6–9.

    PubMed  CAS  Google Scholar 

  47. Ramos-Zepeda, R., and Gonzalez-Mendoza, A., 1986, Metabolic activity of phagocytes in experimental sporotrichosis, Mycopathologia 93: 109–112.

    Article  PubMed  CAS  Google Scholar 

  48. Fine, D. P. (ed.), 1981, Complement and Infectious Diseases, CRC press, Inc., Boca Raton.

    Google Scholar 

  49. Torinuki, W, and Tagami, H., 1985, Complement activation by Sporothrix schenckii, Arch. Dermatol. Res. 277: 332–333.

    Article  PubMed  CAS  Google Scholar 

  50. Noguchi, T., 1972, Immunochemical studies on Sporotrichum schenckii, I. Extraction and chemical composition of the immunologically active substances, Acta Sch. Med. Univ. Gifu 20: 335–343.

    CAS  Google Scholar 

  51. Shimonaka, H., Noguchi, T., Kawai, K., Hasegawa, I., Nasawa, I., and Ito, Y., 1975, Immunochemical studies on the human pathogen Sporothrix schenckii: effects of chemical and enzymatic modification of the antigenic compounds upon immediate and delayed reactions, Infect. Immun. 11: 1187–1194.

    PubMed  CAS  Google Scholar 

  52. Shiraishi, A., Nakagaki, K., and Arai, T., 1979, Experimental sporotrichosis in congenitally athymic (nude) mice, RES J. Reticuloendothel. Soc. 26: 333–336.

    CAS  Google Scholar 

  53. Lurie, H. I., 1971, Sporotrichosis, in: The Pathologic Anatomy of Mycoses: Human Infection with Fungi, Actinomyces and Algae ( E. Uehlinger, ed.), Springer—Verlag, New York, pp. 614–675.

    Google Scholar 

  54. Hachisuka, H., and Sasai, Y., 1980, Subpopulations of lymphocytes in the infiltrate of experimental sporotrichosis, Mycopathologia 76: 167–169.

    Article  Google Scholar 

  55. Charoenvit, Y., and Taylor, R. L., 1979, Experimental sporotrichosis in Syrian hamsters, Infect. Immun. 23: 366–372.

    PubMed  CAS  Google Scholar 

  56. Roberts, G. D., and Larsh, H. W, 1971, The serologic diagnosis of extracutaneous sporotrichosis, Am. J. Clin. Pathol. 56: 597–600.

    PubMed  CAS  Google Scholar 

  57. Roberts, G. D., and Larsh, H. W, 1971, A study of the immunocytoadherence test in the serology of experimental sporotrichosis, J. Infect. Dis. 124: 264–269.

    Article  PubMed  CAS  Google Scholar 

  58. Plouffe, J. E, Jr., Silva, J., Jr., Fekety, R., Reinhalter, E., and Brown, R., 1979, Cell-mediated immune responses in sporotrichosis, J. Infect. Dis. 139: 152–157.

    Article  PubMed  Google Scholar 

  59. Steele, R. W, Cannady, P. B., Jr., Moore, W. L., Jr., and Gentry, L. O., 1976, Skin test and blastogenic responses to Sporotrichum schenckii, J. Clin. Invest. 57: 156–160.

    Article  PubMed  CAS  Google Scholar 

  60. Barbee, W. C., Ewert, A., and Folse, D., 1977, The combined effect of a cutaneo-lymphatic fungus, Sporothrix schenckii, and a lymphatic-dwelling nematode, Brugia malayi, Trop. Geogr. Med. 29: 65–73.

    PubMed  CAS  Google Scholar 

  61. Macdonald, E., Ewert, A., and Rietmeyer, J. C., 1980, Reappearance of Sporothrix schenckii lesions after administration of Solu-Medrol® to infected cats, Sabouraudia 18: 295–300.

    Article  PubMed  CAS  Google Scholar 

  62. Hachisuka, H., and Sasai, Y., 1981, Development of experimental sporotrichosis in normal and modified animals, Mycopathologia 76: 79–82.

    Article  PubMed  CAS  Google Scholar 

  63. Travassos, L. R., and Lloyd, K. O., 1980, Sporothrix schenckii and related species of Ceratocystis, Microbiol. Rev. 44: 683–721.

    CAS  Google Scholar 

  64. Andrieu, S., Giquest, J., and Massamba, S., 1971, Etude immunologique comparee de Sporothrix schenckii et des souches saprophytes voisines, Sabouraudia 9: 206–209.

    Article  PubMed  CAS  Google Scholar 

  65. Karlin, J. V, and Nielsen, H. S., Jr., 1970, Serologic aspects of sporotrichosis, J. Infect. Dis. 121: 316–327.

    Article  PubMed  CAS  Google Scholar 

  66. McMillen, S., 1974, The serology of sporotrichosis, in: The Diagnosis and Treatment of Fungal Infections, (H. M. Robinson, Jr., ed.), Charles C. Thomas, Springfield, pp. 401–409.

    Google Scholar 

  67. Kaufman, L., and Reiss, E., 1986, Serodiagnosis of Fungal Diseases, in: Manual of Clinical Laboratory Immunology, 3rd Ed., (N. R. Rose, H. Friedman, and J. L. Fahey, eds.), American Society for Microbiology, Washington, D. C., pp. 446–466.

    Google Scholar 

  68. de Alborno, M. B., Villaneuva, E., and de Torres, E. D., 1984, Application of immunoprecipitation techniques to the diagnosis of cutaneous and extracutaneous forms of sporotrichosis, Mycopathologia 85: 177–183.

    Google Scholar 

  69. Scott, E. N., and Muchmore, H. G., 1989, Immunoblot analysis of antibody responses to Sporothrix schenckii, J. Clin. Microbiol. 27: 300–304.

    PubMed  CAS  Google Scholar 

  70. Russell, B., Beckett, J. H., and Jacobs, P. H., 1979, Immunoperoxidase localization of Sporothrix schenckii and Cryptococcus neoformans, Arch. Dermatol. 115: 433–435.

    Article  PubMed  CAS  Google Scholar 

  71. Restrepo, A., Robledo, J., Gomez, I., Tabares, A. M., and Gutierrez, M. T., 1986, Itraconazole therapy in lymphangitic and cutaneous sporotrichosis, Arch. Dermatol. 122: 413–417.

    Article  PubMed  CAS  Google Scholar 

  72. Hiruma, M., Katoh, T., Yamamoto, I., and Kagawa, S., 1987, Local hyperthermia in the treatment of sporotrichosis, Mykosen 30: 315–321.

    Article  PubMed  CAS  Google Scholar 

  73. Tarnowski, G. S., 1975, Approaches to the immunotherapy of experimental tumours, in: Host Defense Against Cancer and its Potentiation, ( D. Mizuna, ed.), University Park Press, Baltimore, pp. 389–396.

    Google Scholar 

  74. Previato, J. O., Gorin, P. A. J., Haskins, R. H., and Travassos, L. R., 1979, Soluble and insoluble glucans from different cell types of the human pathogen Sporothrix schenckii, Exp. Mycol. 3: 92–105.

    Article  CAS  Google Scholar 

  75. Whistler, R. L., Bushway, A. A., Singh, P. P., Nakahara, W, and Tokuzen, R., 1976, Noncytotoxic, antitumor polysaccharides, Adv. Carbohydr. Chem. 32: 235–275.

    CAS  Google Scholar 

  76. Kubelka, C. E, 1980, Inibiacao de Sarcoma 180 e aumento de endocitose de macrogos peritoneais de camundongos por polissacaridios de fungos, Thesis, M. Sc., Federal University of Rio de Janeiro, Brasil.

    Google Scholar 

  77. Travassos, L. R., 1989, Antigenic structure of Sporothrix schenckii, in: Immunology of Fungal Diseases, Volume 47, ( E. Kurstak, ed.), Marcel Dekker, Inc., New York, pp. 193–242.

    Google Scholar 

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Scott, E.N., Muchmore, H.G. (1993). Sporotrichosis. In: Murphy, J.W., Friedman, H., Bendinelli, M. (eds) Fungal Infections and Immune Responses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2400-1_6

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