Abstract
The development of experimental sporotrichosis was examined in immunologically-disturbed mice. In the case of intracutaneous inoculation, the lesion in cyclophosphamide-treated mice enlarged strikingly up to 6 days, but at 12 days it was similar in size to that in non-treated mice. The lesion in irradiated mice developed slowly up to 12 days, but thereafter it developed promptly. In nude mice, the lesion was smallest during the development of the lesion. Histological examination showed that numerous organisms were present in the lesion of nude and irradiated mice. Intraperitoneal inoculation showed that dissemination of spores were easily induced in nude mice as compared with littermate mice. These results indicate an important role of cellular immunity in the defence mechanism of sporotrichosis.
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References
Corbel M. J. & Eades, S. M., 1977. Experimental mycormycosis in congenital athymic (nude) mice. Mycopathologia. 62: 117–120.
Emmerling, P., Finger, H. & Boekemühl, J., 1975. Listeria monocytogenes infection in nude mice. Infect. Immunity. 12: 437–439.
Hazen, E. L., Gordon, M. A. & Reed, F. C., 1970. Sporotrichosis. In: Laboratory Identification of Pathogenic Fungi Simplified, pp. 80–83. Charles C Thomas, Springfield.
Fetter, B. F. & Tindall, J. P., 1964. Cutaneous sporotrichosis. Arch. Path. 78: 613–617.
Hachisuka, H. & Sasai, Y., 1980. A peculiar case of sporotrichosis. Dermatologica. 160: 37–40.
Hachisuka, H. & Sasai, Y., 1980. Subpopulation of lymphocytes in the infiltrate of experimental sporotrichosis. Mycopathologia. 71: 167–170.
Lerman, S. P. & Weidanz, W. P., 1970. The effect of cyclophosphamide on the ontogeny of the humoral immune response in chickens. J. Immunol. 105: 614–619.
Lever, W. F. & Lever, G. S., 1975. Sporotrichosis. In: Histopathology of the Skin. pp. 324–326. Lippincott, Philadelphia.
Robinson, H. M., 1974. The Serology of Sporotrichosis. In: The Diagnosis and Treatment of Fungal Infection. pp. 401–409. Charles C. Thomas, Springfield.
Sher, N. A., Chaparas, S. D., Greenberg, L. E., Merchant, E. B. & Vickers, J. H., 1975. Response of congenitally athymic (nude) mice to infection with Mycobacterium bovis (strain BCG). J. Nat. Cancer Inst. 54: 1419–1426.
Steele, R. W., Cannady, P. B. Jr., Moore, W. L. Jr. & Gentry, L. D., 1976. Skin test and blastogenic response to sporotrichum schenckii. J. Clin. Invest. 57: 156–160.
Stockman, G. D., Heim, L. R., South, M. A. & Trentin, J. J., 1973. Differential effects of cyclophosphamide on the B and T cell compartments of adult mice. J. Immunol. 110: 277–282.
WHO Technical Report Series. No. 519., 1973. Cell-mediated Immunity and Resistance of Infection. pp. 37–38. World Health Organization, Geneva.
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Hachisuka, H., Sasai, Y. Development of experimental sporotrichosis in normal and modified animals. Mycopathologia 76, 79–82 (1981). https://doi.org/10.1007/BF00443754
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DOI: https://doi.org/10.1007/BF00443754