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Immunoglobulin Diversity

Regulation of Expression of Immunoglobulin Genes during Primary Development of B Cells

  • Chapter
Biological Regulation and Development

Part of the book series: Biological Regulation and Development ((BRD,volume 2))

Abstract

Since it was perceived that the capacity of immunoglobulin molecules to bind specifically to antigenic determinants was determined by their amino acid sequences, and therefore represented genetic information, there have been impressive attempts to clarify the problem of how the immense diversity of genes coding for antibody molecules of different specificities might be generated. Approaches to the question of generation of diversity have been largely based on comparative analysis of the amino acid sequences of the immunoglobulin molecules derived from plasma cell tumors of mice and humans. These studies have provided fundamental information on the nature of the structural genes that code for immunoglobulin molecules, have given insights into their evolution, and have defined constraints within which models for the generation of diversity must be fitted (Hood et al., 1977 b).

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Authors and Affiliations

  1. Departments of Pediatrics and Microbiology, The Cellular Immunology Unit of the Tumor Institute, Birmingham, Alabama, 35294, USA

    Alexander R. Lawton, John F. Kearney & Max D. Cooper

  2. Comprehensive Cancer Center, University of Alabama in Birmingham, Birmingham, Alabama, 35294, USA

    Alexander R. Lawton, John F. Kearney & Max D. Cooper

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  1. Alexander R. Lawton
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  2. John F. Kearney
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  3. Max D. Cooper
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Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    Robert F. Goldberger

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Lawton, A.R., Kearney, J.F., Cooper, M.D. (1980). Immunoglobulin Diversity. In: Goldberger, R.F. (eds) Biological Regulation and Development. Biological Regulation and Development, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9933-9_9

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  • DOI: https://doi.org/10.1007/978-1-4684-9933-9_9

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