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Antigen-Binding Receptors on Lymphocytes

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Contemporary Topics in Immunobiology

Abstract

The concept that activation of immunocompetent cells by antigen depends upon the presence of specific antigen-binding receptors on the cell surface has been central to immunologic theory since it was originally proposed by Paul Ehrlich (1900). Direct evidence for the existence of such receptors has been amassed in recent years. In particular, it has been demonstrated that in nonimmunized animals, rare lymphocytes will bind a given substance to their surface and that the frequency of such cells increases upon immunization (Naor and Sulitzeanu, 1967; Byrt and Ada, 1969; Davie and Paul, 1971; Humphrey and Keller, 1970; Davie et al, 1971a).

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Author information

Authors and Affiliations

  1. Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA

    Joseph M. Davie

  2. Department of Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

    Joseph M. Davie

  3. Laboratory of Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    William E. Paul

Authors
  1. Joseph M. Davie
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  2. William E. Paul
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Editors and Affiliations

  1. Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    M. G. Hanna

  2. University of Alabama, Birmingham, Alabama, USA

    Max D. Cooper

  3. The Walter and Eliza Hall Institute, Victoria, Australia

    Noel L. Warner

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© 1974 Plenum Press, New York

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Davie, J.M., Paul, W.E. (1974). Antigen-Binding Receptors on Lymphocytes. In: Hanna, M.G., Cooper, M.D., Warner, N.L. (eds) Contemporary Topics in Immunobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3045-5_7

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  • DOI: https://doi.org/10.1007/978-1-4684-3045-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3047-9

  • Online ISBN: 978-1-4684-3045-5

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