Abstract
The emphasis in this discussion will be on early events in differentiation of antibody-producing cells, an area of immunology that is in its experimental infancy. Most of the available information on the antibody problem emerged from analyses of relatively mature cells of the plasma cell lineage and the end products they secrete. Several useful theories on the development of antibody heterogeneity taking into account the diversity and specificity of antibody molecules, the restrictions imposed by genetic and structural analyses, and the phenomenon of self-recognition have been proposed. However, the paucity of knowledge of the origin, identity, and characterization of pre-antibody forming cells has been a handicap in the struggle toward a final solution of this problem.
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Cooper, M.D., Lawton, A.R., Kincade, P.W. (1972). A Developmental Approach to the Biological Basis for Antibody Diversity. In: Hanna, M.G. (eds) Contemporary Topics in Immunobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3042-4_2
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DOI: https://doi.org/10.1007/978-1-4684-3042-4_2
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