Functions of DNA Helicases in the DNA Metabolism of Escherichia Coli

  • Mahmoud Abdel-Monem
  • Helen M. Arthur
  • Inga Benz
  • Hartmut Hoffmann-Berling
  • Ursula Reygers
  • Anita Seiter
  • Gisela Taucher-Scholz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 179)


DNA helicases catalyze the separation of double-stranded DNA into single strands using the energy of ATP hydrolysis. The four helicases which have been found in Escherichia coli are listed in Table 1. These enzymes are the helicases I, II, III and the helicase specified by the rep gene. As the table shows the four proteins differ considerably with respect to Mr, number of molecules per cell and, in particular, mechanism of action. Each of the helicases requires a region of single-stranded DNA to initiate unwinding, and each of the four enzymes unwinds DNA unidirectionally relative to the chemical polarity of the DNA strand to which it is bound. The direction of unwinding depends on the nature of the helicase.


Replication Fork Chromosomal Replication Chemical Polarity Single Strand Binding Protein Helicase Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Mahmoud Abdel-Monem
    • 1
  • Helen M. Arthur
    • 2
  • Inga Benz
    • 1
  • Hartmut Hoffmann-Berling
    • 1
  • Ursula Reygers
    • 1
  • Anita Seiter
    • 1
  • Gisela Taucher-Scholz
    • 1
  1. 1.Abteilung Molekulare BiologieMax-Planck-Institut für medizinische ForschungHeidelbergFederal Republic of Germany
  2. 2.Department of BiochemistryThe University of Newcastle upon TyneNewcastle upon TyneUK

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