Proteins Involved in DNA Replication

  • Ulrich Hübscher
  • Silvio Spadari

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 179)

Table of contents

  1. Front Matter
    Pages i-xii
  2. In Vitro Prokaryotic DNA Replication Systems

    1. Front Matter
      Pages 1-1
    2. C. Victor Jongeneel, Timothy Formosa, Maureen Munn, Bruce M. Alberts
      Pages 17-33
    3. Margarita Salas, Luis Blanco, Ignacio Prieto, Juan A. García, Rafael P. Mellado, José M. Lázaro et al.
      Pages 35-44
    4. K. Geider, T. F. Meyer, I. Bäumel, A. Reimann
      Pages 45-54
    5. Ramon Diaz, Walter L. Staudenbauer
      Pages 55-61
    6. N. Patrick Higgins, Purita Manlapaz-Ramos, Baldomero M. Olivera
      Pages 63-67
    7. Anne Resibois, Martin Pato, Patrick Higgins, Ariane Toussaint
      Pages 69-76
  3. In Vitro Eukaryotic DNA Replication Systems, Chromosomal and Viral Replication Studies

    1. Front Matter
      Pages 91-91
    2. Peter C. van der Vliet, Bram G. M. van Bergen, Wim van Driel, Dick van Dam, Marijke M. Kwant
      Pages 93-105
    3. J. M. Bonneville, M. Volovitch, N. Modjtahedi, D. Demery, P. Yot
      Pages 113-119
    4. Wolfgang Pülm, Rolf Knippers
      Pages 127-141
    5. J.-M. Vos, B. Avalosse, Z. Z. Su, J. Rommelaere
      Pages 143-150
    6. Nicholas Muzyczka, Richard J. Samulski, Paul Hermonat, Arun Srivastava, Kenneth I. Berns
      Pages 151-161
    7. Silvio Spadari, Francesco Sala, Guido Pedrali-Noy
      Pages 169-181

About this book

Introduction

This book collects the Proceedings of a workshop sponsored by the European Molecular Biology Organization (EMBO) entitled "Pro­ teins Involved in DNA Replication" which was held September 19 to 23,1983 at Vitznau, near Lucerne, in Switzerland. The aim of this workshop was to review and discuss the status of our knowledge on the intricate array of enzymes and proteins that allow the replication of the DNA. Since the first discovery of a DNA polymerase in Escherichia coli by Arthur Kornberg twenty eight years ago, a great number of enzymes and other proteins were des­ cribed that are essential for this process: different DNA poly­ merases, DNA primases, DNA dependent ATPases, helicases, DNA liga­ ses, DNA topoisomerases, exo- and endonucleases, DNA binding pro­ teins and others. They are required for the initiation of a round of synthesis at each replication origin, for the progress of the growing fork, for the disentanglement of the replication product, or for assuring the fidelity of the replication process. The number, variety and ways in which these proteins inter­ act with DNA and with each other to the achievement of replication and to the maintenance of the physiological structure of the chromo­ somes is the subject of the contributions collected in this volume. The presentations and discussions during this workshop reinforced the view that DNA replication in vivo can only be achieved through the cooperation of a high number of enzymes, proteins and other cofactors.

Keywords

ATPase DNA Isomer Mammalia biology enzyme enzymes genetics molecular biology polymer proteins replication structure synthesis system

Authors and affiliations

  • Ulrich Hübscher
    • 1
  • Silvio Spadari
    • 2
  1. 1.University of ZurichZurichSwitzerland
  2. 2.Institute of Biochemical and Evolutionary GeneticsCNRPaviaItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-8730-5
  • Copyright Information Springer Science+Business Media New York 1984
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-8732-9
  • Online ISBN 978-1-4684-8730-5
  • Series Print ISSN 0065-2598
  • About this book