Continuing the Investigation
Numerous questions are left unanswered in this volume and provide most intriguing areas for further investigations. In spite of considerable progress, knowledge is far from satisfactory even in the field of acute neurological diseases for which a definite direct etiology is well established. For some of these diseases, Japanese encephalitis for example, we are in great need of efficient vaccines.1 In addition, for such diseases it is especially urgent to develop better diagnostic procedures, since in even the most modern diagnostic virology facilities the etiologic agent remains unrecognized in over 30% of presumed cases of acute viral meningitis and in over 80% of presumed cases of acute viral encephalitis. Indeed, the precise etiologic diagnosis of viral infection of the nervous system (NS) in general is still fraught with difficulties. For example, the association of cerebral malformations and other neurological birth defects with antecedent viral infection of the mother is often beyond present methodologies.
KeywordsHuman Immunodeficiency Virus Japanese Encephalitis Rubella Virus Viral Etiology Japanese Encephalitis Vaccine
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