Abstract
JC virus is a human papovavirus that has been implicated as the causative agent in the chronic human demyelinating disease progressive multifocal leukoencephalopathy (PML). Although the virus is widespread in human populations1, 2, PML in a rare opportunistic disease that occurs primarily in patients with compromised immune systems3. The incidence of PML has increased recently in association with HIV infection4. Numerous studies have shown viral particles within abnormal oligodendrocytes from PML brains5 and the aetiology of demyelination is thought to be due to lytic destruction of these myelin-forming cells. Astrocytes can have bizarre morphologies in PML brains that include some features of transformed cells. Virions are rarely found in electron micrographs of these morphologically altered cells5.
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References
Gardner, S. D. (1973). Prevalence in England of antibody to human polyomavirus (BK). Br. Med. J., 1, 77–8
Padgett, B. L. and Walker, D. L. (1973). Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leukoencephalopathy. J. Infect. Dis., 127, 467–70
Johnson, R. T. (1983). Evidence for polyomaviruses in human neurological diseases. In Sever, J. L. and Madden, D. L. (eds.) Polyomaviruses and Human Neurological Disease. pp. 183–90. ( New York: Alan R. Liss )
Levy, R. M., Bredesen, D. E. and Rosenblum, M. L. (1985). Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): Experience at UCSF and review of the literature. J. Neurosurg., 62, 475–95
ZuRhein, G. M. (1972). Virions in progressive multifocal leukoencephalopathy. In Minkler, J. (ed.) Pathology of the Nervous System. Vol. 3, pp. 2893–912. ( New York: McGraw-Hill )
Walker, D. L., Padgett, B. L., ZuRhein, G. M., Albert, A. E. and Marsh, R. F. (1973). Human papovavirus (JC): induction of brain tumors in hamsters. Science, 181, 674–6
Padgett, B. L., Walker, D. L., ZuRhein, G. M. and Verakis, J. N. (1977). Differential neuro-oncogenicity of strains of JC virus, a human polyoma virus, in newborn Syrian hamsters. Cancer Res., 37, 718–20
Varakis, J., ZuRhein, G. M., Padgett, B. L. and Walker, D. L. (1978). Induction of peripheral neuroblastomas in Syrian hamsters after injection as neonates with JC virus, human polyoma virus. Cancer Res., 38, 1718–22
London, W. T., Houff, S. A., Madden, D. L., Fuccillo, D. A., Gravell, M., Wallen, W. C., Palmer, A. E., Sever, J. L., Padgett, B. L., Walker, D. L., ZuRhein, G. M. and Ohashi, T. (1978). Brain tumors in owl monkeys inoculated with a human polyoma virus (JC virus). Science, 102, 1246–9
Tooze, J. (1981). The Molecular Biology of Tumor Viruses. ( Cold Spring Harbor: Cold Spring Harbor Laboratory Press )
Small, J. A., Scangos, G. A., Cork, L., Jay, G. and Khoury, G. (1986). The early region of human papovavirus JC induces dysmyelination in transgenic mice. Cell, 46, 13–18
Gordon, J. W. and Ruddle, F. H. (1983). Gene transfer into mouse embryos: production of transgenic mice by pronuclear injection. Methods Enzymol., 101, 411–33
Small, J. A., Khoury, G., Jay, G., Hawley, P. M. and Scangos, G. A. (1986). Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc. Natl. Acad. Sci. USA, 83, 8288–92
Trapp, B. D., Itoyama, Y., Maclntosh, T. D. and Quarles, R. H. (1983). P2 protein in oligodendrocytes and myelin of the rabbit central nervous system. J. Neurochem, 40, 47–54
Trapp, B. D., Moench, T., Pulley, M., Barbosa, E., Tennekoon, G. and Griffin, J. (1987). Spatial segregation of mRNA encoding myelin-specific proteins. Proc. Natl. Acad. Sci. USA, 84, 7773–7
Trapp, B. D., Small, J. A., Pulley, M., Khoury, G. and Scangos, G. A. (1988). Dysmyelinadon in transgenic mice containing JC virus early region. Ann. Neurol., 23, 38–48
Kenney, S., Natarajan, V., Strike, D., Khoury, G. and Salzman, N. P. (1984). JC virus enhancer-promoter active in human brain cells. Science, 226, 1337–9
Lees, M. B. and Brostaff, S. W. (1984). Proteins of myelin. In Morell, P. (ed.) Myelin. 2nd edn., pp. 197–224. ( New York: Plenum Press )
Quarles, R. H. (1983/1984). Myelin-associated glycoprotein in development and disease. Dev. Neurosci., 6, 285–303
Eng, L. F. (1980). The ghat fibrillary acidic (GFA) protein. In Bradshaw, R. A. and Schneider, D. (eds.) Proteins of the Nervous System. pp. 85–117. ( New York: Raven Press )
Hogan, E. L. and Greenfield, S. (1982). Animal models of genetic disorders of myelin. In Morell, P. (ed.) Myelin. 2nd edn., pp. 489–534. ( New York: Plenum Press )
DePamphilis, M. L. and Wassarman, P. M. (1982). Organization and replication of papovavirus DNA. In Kaplan, A. S. (ed.) Organization and Replication of Viral DNA. pp. 37–114. ( Boca Raton: CRS Press Inc. )
Rigby, P. W. J. and Land, P. D. (1983). Structure and function of Simian virus-40 large T-antigen. Adv. Virol. Oncol., 3, 31–47
Huber, B., Vakalopaulou, E., Burger, C. and Fanning, E. (1985). Identification and biochemical analysis of DNA replication-defective large T-antigens from SV40-transformed cells. Virology, 146, 188–202
Cole, C. N., Tornow, J., Clark, R. and Tjian, R. (1986). Properties of the simian virus 40 (SV40) large T-antigens encoded by SV40 mutants with deletions in gene A. J. Virol., 57, 539–46
Stahl, H., Droge, P. and Knippers, R. (1986). DNA helicase activity of SV40 large tumor antigen. EMBO J., 5, 1939–44
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Trapp, B.D., Small, J.A., Scangos, G.A. (1988). Dysmyelination in Transgenic Mice Containing the Early Region of JC Virus. In: Johnson, R.T., Lyon, G. (eds) Virus Infections and the Developing Nervous System. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1243-4_3
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DOI: https://doi.org/10.1007/978-94-009-1243-4_3
Publisher Name: Springer, Dordrecht
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