Abstract
Humans are exposed to carcinogens from a variety of sources including food, drinking water, air, and the working environment. A few of these carcinogens have been identified epidemiologically, but the majority have been identified by animal bioassays and their impact on human cancer is not well established. The mathematical quantitation of human cancer risk from exposures to animal carcinogens relies on the validity of animal to man extrapolations. Several pieces of information could increase the validity of such extrapolations. Among these, comparative pharmacokinetic data from the relevant test animals and from man are particularly important because these data will tell to what extent the compound is handled similarly and whether it elicits toxicity by the same mechanism in the two species. The quantitation of human risk is also highly dependent on data providing the actual human exposure levels. Futhermore, large interindividual variations in exposures and in pharmacokinetics are most probably found for most carcinogens in human populations. Therefore this variability should also be validated in order not to underestimate the risk to certain groups or individuals.
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Literature
Adamkiewicz, J., Drosdziok, W., and Eberhardt, W., Langenberg, U., and Rajewsky, M. F., 1983, High-affinity monoclonal antibodies specific for DNA components structurally modified by alkylating agents, Banbury Report 13: 265.
Adamkiewicz, J., Nehls, P., and Rajewsky, M. F., 1984, Immunological methods for detection of carcinogen-DNA adducts, In: “Monitoring human exposure to carcinogenic and mutagenic agents,” A. Berlin, M. Draper, K. Hemminki, H. Vainio, eds., International Agency for Research on Cancer, Lyon.
Ashby, J., 1988, Comparison of techniques for monitoring human exposure to genotoxic chemicals, Mutat. Res. 204: 543.
Brothman, A. R., Davis, T. P., Duffy, J. J., and Lindell, T. J., 1982, Development of an antibody to actinomycin D and its application for the detection of serum levels by radioimmunoassay, Cancer Res., 42: 1184.
Caviezel, M., Aeschbach, A. P., Lutz, W. K., and Schlatter, C., 1984, Reduction of covalent binding of aflatoxin B1 to rabbit liver DNA after immunization against this carcinogen, Arch. Toxicol., Supp1. 7: 249.
Creech, H. J., 1952, Chemical and immunological properties of carcinogen-protein conjugates. Cancer Res. 12: 557.
Dragsted, L. O., Bull, I., and Autrup, H., 1988, Substances with affinity to a monoclonal aflatoxin B1 antibody in Danish urine samples, Fd. Chem. Toxic. 26: 233.
Eggset, G., Volden, G., and Krokan, H., 1983, U.v.-induced DNA damage and its repair in human skin in vivo studied by sensitive immunohistochemical methods, Carcinog. 4: 745.
Erlanger, B., and Beiser, S., 1964, Antibodies specific for ribonucleosides, ribonucleotides and their reaction with DNA, Proc. Natl. Acad. Sci. USA, 52: 68
Fan, T. S. L., Zhang, G. S., and Chu, F. S., 1984, Production and characterisation of antibody against aflatoxin Q1, Appl. Environ. Microbiol. 47: 526.
Farmer, P. B., Neumann, H.-G., and Henschler, D., 1987, Estimation of exposure of man to substances reacting covalently with macromolecules, Arch Toxicol 60: 251.
Foiles, P. G., Truschin, N., and Castonguay, A., 1985, Measurement of 06-methyldeoxyguanosine in DNA methylated by the tobacco-specific carcinogen 4-(methylnitrosamino)1-(3-pyridyl)-l-butanone using a biotin-avidin enzyme-linked immunosorbent assay, carcinogenesis 6: 989.
Fujiwara, K., Saikusa, H., Yasuno, M., and Kitagawa, T., 1982, Enzyme immunoassay for the quantification of mitomycin C using B-galactosidase as a label, Cancer Res., 42: 1487.
Groopman, J.D., Trudel, L.J., Donahue, P.R., MarshakRothstein, A., and Wogan, G.N., 1984, High-affinity monoclonal antibodies for aflatoxins and their application to solid-phase immunoassays, Proc. Natl. Acad., 81: 7728.
Groopman, J. D., Donahue, P.R., Zhu, J., Chen, J., and Wogan, G. N., 1985, Aflatoxin metabolism in humans: Detection of metabolites and nucleic acid adducts in urine by affinity chromatography, Proc. Natl. Acad. Sci. 82: 6492.
Harris, C. C., Vähäkangas, K., Newman, M. J., Trivers, G. E., Shamsuddin, A., Sinopoli, N., Mann, D. L., and Wright, W. E., 1985, Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers, Proc. Natl. Acad. Sci. 82: 6672.
Haugen, Aa., Becher, G., Benestad, C., Vähäkangas, K., Trivers, G. E., Newman, M. J., and Harris, C. C., 1986, Determination of polycyclic aromatic hydrocarbons in the urine, benzo[a]pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycyclic aromatic hydrocarbons in the work atmosphere, Cancer Res. 46: 4178.
Haugen, AA., Groopman, J.D., Hsu, I-C., Goodrich, G.R., Wogan, and Harris, C.C., 1981, Monoclonal antibody to aflatoxin B1-modified DNA detected by enzyme immunoassay, Proc. Natl. Acad. Sci., 78: 4124.
Hertzog, P. J., Lindsay Smith, J. R., and Garner, R. C., 1982, Production of monoclonal antibodies to guanine opened aflatoxin B1 DNA, the persistent DNA adduct in vivo, Carcinog., 3: 825.
Hsu, I.C., Poirier, M.C., Yuspa, S.H., Yolken, R.H., and C.C. Harris, 1980, Ultrasensitive enzymatic radioimmunoassay (USERIA) detects femtomoles of acetylaminofluorene-DNA adducts, Carcinog. 1: 455.
Hsu, I-C., Poirier, M. C., Yuspa, S. H., Grunberger, D., Weinstein, I. B., Yolken, R. H., and Harris, C. C., 1981, Measurement of benzo[a]pyrene-DNA adducts by enzyme immunoassays and radioimmunoassay, Cancer Res., 41: 1091.
Johnson, H. J., Jr., Cemosek, S. F.,Jr., Gutierrez-Cemosek, R. M., and Brown, L. L., 1980, Development of a radioimmunoassay procedure for 4-acetamidobiphenyl, a metabolite of the chemical carcinogen 4-aminobiphenyl, in urine, J. of Anal. Tox. 4: 86.
Kriek, E., Engelse, L. D., Scherer, E., and Westra, G., 1984, Formation of DNA modifications by chemical carcinogens identification, localisation and quantification, Biochim. Biophvs. Acta 738: 181.
Leng, M., Sage, E., Fuchs, R. P., and Daune, M. P., 1978, Antibodies to DNA modified by the carcinogen, N-acetoxyN-2-acetylaminofluorene, FEBS Lett., 92: 207.
Malfoy, B., Hartmann, B., Macquet, J-P., and Leng, M., 1981, Immunochemical studies of DNA modified by cis-dichlorodiammineplatinum(II) in vivo and in vitro, Cancer Res. 41: 4127.
Martin, C. N., Garner, R. C., Tursi, F., Garner, J. V., Whittle, H. C., Sizaret, R. P., and Montesano, R., 1984, An elisa Procedure for assaying aflatoxin B1, in Berlin, A., Draper, M., Hemminki, K. & Vainio, H. eds. Monitoring Human Exposure to Carcinogenic and Mutagenic Agents (IARC Scientific Publications No. 59 ), International Agency for Research on Cancer, Lyon.
Menkveld, G. J., Van Der Laken, C. J., Hermsen, T., Kriek, E., Scherer, E., and Den Engelse, L., 1985, Immunohistochemical localisation of 06-ethyldeoxyguanosine and deoxyguanosin-8-y1-(acetyl)aminofluorene in liver sections of rats treated with diethylnitrosamine, ethylnitrosourea or N-acetylaminofluorene, Carcinog. 6: 263.
Moolten, F. L., Schreiber, B., Rizzone, A., Weiss, A. J., and Boger, E., 1981, Protection of mice against 7,12-dimethylbenz[a]anthracene-induced skin tumors by immunization with afluorinated analog of the carcinogen, Cancer Res, 41: 425.
Moss, E. J., and Neal, G. E., 1985, The metabolism of aflatoxin B1 by human liver, Biochem. Pharmacol. 34: 3193.
Müller, R., and Rajewsky, M.R., 1980, Immunological quantification by high-affinity antibodies of 06-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea, Cancer Res. 40: 887.
Nehls, P.,Adamkiewicz, J., and Rajewsky, M. F., 1984, ImmunoSlot-Blot: A highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNA, J. Cancer Res. Clin. Oncol. 108: 23.
Osterman-Golkar, S., Hultmark, D., Segerbäck, D., Calleman, C. J., Gothe, R., Ehrenberg, L., and Wachtmeister, C. A., 1977, Alkylation of DNA and proteins in mice exposed to vinyl chloride, Biochem. Biophys. Res. Commun. 76: 259.
Perera, F. P., Santella, R. M., and Poirier, M. C., 1985, Potential methods to monitor human populations exposed to carcinogens: Carcinogen-Dna binding as an example, in: “Risk quantitation and regulatory policy,” D. G. Hoel, R. A. Merrill, F. P. Perera, eds., Cold Spring Harbor Laboratory, Cold Spring Harbor.
Perera, F. P., 1987, Molecular Cancer Epidemiology: A new tool in cancer prevention, JNCI 78: 887.
Pestka, J. J., Li, Y. K., and Chu, F. S., 1982, Reactivity of aflatoxin B2a antibody with aflatoxin B1-modified DNA and related metabolites, Appl. Environ. Microbiol. 44: 1159.
Pestka, J. J., and Chu, F. S., 1984, Aflatoxin B1 dihydrodiol antibody: Production and specificity, AApl. Environ. Microbiol. 47: 472.
Plooy, A.C.M., van Dijk, M., and Lohman, P.H.M., 1984, Induction and repair of DNA cross-links in Chinese hamster ovary cells treated with various platinum coordination compounds in relation to platinum binding to DNA, cytotoxicity, Cancer Res. 44: 2043.
Plooy, A. C. M., Fichtinger-Schepman, A. M. J.., Schutte, H. H., van Dijk, M., and Lohman, P. H. M., 1985, The quantitative detection of various Pt-DNA-adducts in Chinese hamster ovary cells treated with cisplatin: application of immunochemical techniques, Carcinoq. 6: 561.
Poirier, M. C., Yuspa, S. H., Weinstein, I. B., and Blobstein, S., 1977, Detection of carcinogen-DNA adducts by radio-immunoassay Nature, 270: 186.
Poirier, M.C., Santella, R., Weinstein, I.B., Grunberger, D., and Yuspa, S. H., 1980, Quantitation of Benzo(a)pyrenedeoxyguanosine adducts by radioimmunoassay, Cancer Res. 40: 412.
Poirier, M.C., 1981, Antibodies to carcinogen-DNA adducts, JNCI, 67: 515.
Poirier, M.C., M.C., Lippard, S.J., Zwelling, L.A., Ushay, H.M., Kerrigan, D., Thill, C.C., Santella, R.M., Grunberger, D., and Yuspa, S.H., 1982, Antibodies elicited against cisdiamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloro-platinum(II)-DNA adducts formed in vivo and in vitro, Proc. Natl. Acad. Sci. 79: 6443.
Poirier, M. C., 1984, The use of carcinogen-DNA adduct antisera for quantitation and localisation of genomic damage in animal and the human population, Environ. Mutagen. 6: 879.
Poirier, M. C., Reed, E., Zwelling, L. A., Ozols, R. F., Litterst, C. L., and Yuspa, S. H., 1985, Polyclonal antibodies to quantitate cis-diamminedichloroplatinum(II)-DNA adducts in cancer patients and animal models, Environ. Hlth. Perspect. 62: 89
Rajewsky, M. F., Müller, R., Adamkiewicz, J., and Drosdziok, W., 1980, Immunological detection and quantification of DNA components structurally modified by alkylating carcinogens (ethylnitrosourea), In: B. Pullman, P. O. P. Tso, H. Gelboin, eds., Carcinogenesis: Fundamental mechanisms and environmental effects, Reidel, Dordrecht.
Reed, E., Yuspa, S. H., Zwelling, L. A., Ozols, R. F., and Poirier, M. C., 1986, Quantitation of cis-Diamminedichloroplatinum II (Cisplatìn)-DNA-Intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy, J. Clin. Invest. 77: 545.
Safhill, R., Strickland, P. T., and Boyle, J. M., 1982, Sensitive radioimmunoassays for 06-n-butyldeoxyguanosine, 02- n-butylthymídine and 04-n-butylthymidine, carcinogenesis 5: 547.
Santella, R.M., Lin, C.D., Cleveland, W.L., and Weinstein, I.B., 1984, Monoclonal antibodies to DNA modified by a benzo[a]pyrene diol epoxide, Carcinogenesis 5: 373.
Santella, R. M., Lin, C. D., and Dharmaraja, N., 1986, Monoclonal antibodies to a benzo[a]pyrene diolepoxide modified protein, Carcinogenesis 7: 441.
Segerbäck, D., 1983, Alkylation of DNA and hemoglobin in the mouse following exposure to ethene and ethene oxide, Chem. Biol Interact 45: 139.
Sizaret, P., Malaveille, C., Montesano R., and Frayssinet, 1982, Detection of aflatoxins and related metabolites by radioimmunoassay, JNCI 69: 1375.
Strickland, P. T., and Boyle, J.M., 1984, Immunoassay of carcinogen modified DNA, Prog. Nucleic Acid Res. Mol. Biol. 31: 1.
Sun, T., Wu Y., and Wu, S., 1983, Monoclonal antibody against aflatoxin B1, and its potential applications, Chinese J. Oncol., 5: 401.
Tsuboi, S., Nakagawa, T., Tornita, M., Seo, T., Ono, H., Kawamura, K., and Iwamura, N., 1984, Detection of Aflatoxin B1 in Serum Samples of Male Japanese Subjects by Radioimmunoassay and High-Performance Liquid Chromatography, Cancer Res. 44: 1231.
Umbenhauer, D., Wild, C.P., Montesano, R., Saffhill, R., Boyle, J.M., Huh, N., Kirstein, U., Thomale, J., Rajewsky, M.F. and Lu, S.H., 1985, 06-Methyldeoxyguanosine in Oesophageal DNA among individuals at high risk of Oesophageal cancer, Int. J. Cancer 36:661.
Vanderlaan, M., Watkins, B.E., Hwang, M., Knize, M. G., and Felton, J.S., 1988, Monoclonal antibodies for the immunoassay of mutagenic compounds produced by cooking beef, Carcinog. 9: 153.
Van der Laken, C. J., Hagenaars, A. M., Hermsen, G., Kriek, E., Kuipers, A. J., Nagel, J., Scherer, E., and Welling, M., 1982, Measurement of 06-ethyldeoxyguanosine and N(deoxyguanosin-8-yl)-N-acetyl-aminofluorene in DNA by high-sensitivity enzyme immunoassays, carcinogenesis 5: 569.
Vainio, H., 1985, Current trends in the biological monitoring of exposure to carcinogens, Scand J Work Environ Health 11: 1
Wani, A. A., Gibson-D’Ambrosio, R. E., and D’Ambrosio, S. M., 1984, Quantitation of 06-ethyldeoxyguanosine in ENU alkylated DNA by polyclonal and monoclonal antibodies, Carcinoq. 5: 1145.
Wild, C. P., Smart, G., Saffhill, R., and Boyle, J. M., 1983, Radioimmunoassay of 06-methyldeoxyguanosine in DNA of cells alkylated in vitro and in vivo, Carcinog. 4: 1605.
Wild, C. P., Umbernhauer, D., Chapot, B., and Montesano, R., 1986, Monitoring of individual human exposure to aflatoxins (AF) and N-Nitrosamines (NNO) by immunoassays, J. Cell. Biochem., 30: 171.
Woychik, N. A., Hinsdill, R. D., and Chu, F. S., 1984, Production and characterisation of monoclonal antibodies Against aflatoxin M1, Appl. Environ. Microbiol., 48:1096.
Yang, G., Nesheim, S., Benavides, J., Ueno, I., Campbell, A. D., and Poland, A., 1980, Radioimmunoassay detection of Aflatoxin B1 in monkey and human urine, Medical Mycology, Zbl. Bakt. suppl. 8: 329.
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© 1989 Plenum Press, New York
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Dragsted, L.O. (1989). Determination of Carcinogen Exposure by Immunological Techniques. In: Travis, C.C. (eds) Biologically Based Methods for Cancer Risk Assessment. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5625-7_23
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DOI: https://doi.org/10.1007/978-1-4684-5625-7_23
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