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Table of contents

  1. Front Matter
    Pages i-ix
  2. Introduction

  3. Biological Bases for Cancer Models

  4. Interspecies Extrapolation of Pharmacokinetics

  5. Promotion as a Factor in Carcinogenesis

    1. Monique Castagna, Isabelle Martelly
      Pages 141-153
    2. R. Schulte-Hermann, W. Parzefall, W. Bursch, I. Timmermann-Trosiener
      Pages 155-163
    3. Tommaso A. Dragani, Giacomo Manenti, Marina R. M. Sacchi, Bruno Colombo, Giuseppe Della Porta
      Pages 193-207
  6. Screening for Carcinogenesis

  7. Cancer Risk Assessment

    1. Rory B. Conolly, Richard H. Reitz, Harvey J. Clewell III, Melvin E. Andersen
      Pages 301-317
    2. J. M. Kaldor, D. E. G. Shuker
      Pages 339-348
  8. Back Matter
    Pages 349-355

About this book

Introduction

"Biologically Based Methods for Cancer Risk Assessment", an Advanced Research Workshop, (ARW) sponsored by the North Atlantic Treaty Organization (NATO) was held in Corfu, Greece in June, 1989. The intent of the workshop was to survey available pharmacokinetic and pharmacodynamic methods in cancer risk assessment and identify methodological gaps and research needs for biologically based methods in cancer risk assessment. Incorporation of such methods represents one of the most challenging areas for risk assessment. The workshop included an international group of invited experts in the field and provided for a dynamic exchange of ideas and accomplishments. Some of the major topics discussed were: * Inventory of available pharmacokinetic and pharmacodynamic methods for cancer risk assessment. * Identification of methodology gaps and research needs in biologically based methods in cancer risk assessment. * Development of a general framework to guide future cancer risk assessment research. This book is a compilation of the papers presented at the workshop and is intended to provide guidance for future research to reduce uncertainties in the cancer risk assessment process. The primary sponsorship of this ARW by NATO and the advice and cooperation of Dr. C. Sinclair of the Scientific affairs Division are gratefully acknowledged. Acknowledgement is also given to the National Science Foundation for its support. The organization of the ARW and the preparation of this book have required considerable help from many other sources.

Keywords

assessment cancer carcinogenesis carcinoma cell cell culture development liver methodology mutagen organizations pharmacodynamics pharmacokinetics research screening

Editors and affiliations

  • Curtis C. Travis
    • 1
  1. 1.Office of Risk AnalysisOak Ridge National LaboratoryOak RidgeUSA

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