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Salmonella Tester Strains: Mutational Targets and Correlation with Animal Carcinogenicity and Teratogenicity

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Mechanisms of DNA Damage and Repair

Part of the book series: Basic Life Sciences ((BLSC,volume 189))

Abstract

Other presentations in this session summarize molecular changes that appear to be primary participants in the activation of cellular protooncogenes. These mutations involve chromosome rearrangements and simple base substitutions. Mutations in human ras genes have been detected that affect codon positions 12 or 61 and involve five of the six possible kinds of base substitutions; only an A/T → C/G transversion had not been detected as of 1984.1 This absence is not surprising because of the limited cases available, the fact that 4 of the 6 base pairs in the first two positions of the normal target codons happen to be G/C base pairs, and the possibility that only a limited set of substitutions may activate the protein product.

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Author notes

  1. Sharon Lea Aukerman

    Present address: Department of Cell Biology, The University of Texas System Cancer, M. D. Anderson Hospital and Tumor Institute, Houston, Texas, 77030, USA

Authors and Affiliations

  1. Department of Biology, The Johns Hopkins University, Baltimore, MD, 21218, USA

    Philip E. Hartman & Sharon Lea Aukerman

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  1. Philip E. Hartman
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Editors and Affiliations

  1. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

  2. Chemistry Department, American University, Washington, D.C., USA

    Michael G. Simic

  3. Johns Hopkins University, Baltimore, Maryland, USA

    Lawrence Grossman

  4. New York University Medical Center, New York, New York, USA

    Arthur C. Upton

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© 1986 Plenum Press, New York

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Hartman, P.E., Aukerman, S.L. (1986). Salmonella Tester Strains: Mutational Targets and Correlation with Animal Carcinogenicity and Teratogenicity. In: Simic, M.G., Grossman, L., Upton, A.C., Bergtold, D.S. (eds) Mechanisms of DNA Damage and Repair. Basic Life Sciences, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9462-8_44

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  • DOI: https://doi.org/10.1007/978-1-4615-9462-8_44

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